Rasmi, YousefJalali, LadanKhalid, SalihaShokati, AmenehTyagi, PoonamOzturk, AlpaslanNasimfar, Amir2023-10-192023-10-19202341043-46661096-0023https://doi.org/10.1016/j.cyto.2023.156253https://hdl.handle.net/20.500.12469/5061Prolactin (PRL) is an endocrine hormone secreted by the anterior pituitary gland that has a variety of physiological effects, including milk production, immune system regulation, and anti-inflammatory effects. Elevated levels of PRL have been found in several viral infections, including 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), a viral pathogen that has recently spread worldwide. PRL production is increased in SARS-CoV2 infection. While PRL can trigger the production of proinflammatory cytokines, it also has several anti-inflammatory effects that can reduce hyperinflammation. The exact mechanism of PRL's contribution to the severity of COVID-19 is unknown. The purpose of this review is to discuss the interaction between PRL and SARS-CoV2 infection and its possible association with the severity of COVID-19.eninfo:eu-repo/semantics/closedAccessNecrosis-Factor-AlphaActivated MacrophagesSignal-TransductionGrowth-HormoneC-JunExpressionCellReceptorMechanismsReleaseNecrosis-Factor-AlphaActivated MacrophagesSignal-TransductionGrowth-HormoneC-JunExpressionProlactinCellSARS-CoV-2ReceptorSeverityMechanismsCOVID-19ReleaseImmunomodulatory effectsArticle169WOS:00105402120000110.1016/j.cyto.2023.1562532-s2.0-85162171729Q3Q237320963