Yelekçi, KemalErensoy, GizemDing, KaiZhan, Chang-GuoElmezayen, Ammar D.Yelekçi, KemalDuracık, MerveÖzakpınar, Özlem BingolKüçükgüzel, İlkay2020-12-122020-12-12202082630-63442630-6344https://hdl.handle.net/20.500.12469/3516https://doi.org/10.35333/jrp.2020.187https://search.trdizin.gov.tr/yayin/detay/362158A series of new 1,3,4-oxadizole derivatives containing thioether group, has been synthesized to investigate their mPGES-1 inhibitory activities. The synthesized compounds were also evaluated for their anticancer and COX-1/2 inhibitory activities. All compounds were checked for their purity using TLC and HPLC analyses. The melting points, elemental analysis, FT-IR, H-1-/C-13-NMR and LR-MS data were utilized for structural characterization. The most potent derivative was 2-[5-{[2-methyl-5-(propan-2-yl)phenoxy]methyl}-1,3,4-oxadiazol-2-yl)sulphanyl]-1-(phenyl)ethan-1-one 3a, which showed inhibitory activity against mPGES-1 with an IC50 of 4.95 mu M. Docking studies with mPGES-1 and COX-1/2 enzymes revealed their affinity and potential binding mechanism for the tested compounds.eninfo:eu-repo/semantics/openAccess1,3,4-OxadiazolesThioethersmPGES-1 inhibitionCOX-1/2 inhibitionAnticancer activityMolecular dockingADME predictionArticle436451424WOS:00055182800000110.35333/jrp.2020.1872-s2.0-85089855689N/AQ3362158