Browsing by Author "Aytekin, Vedat"

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Citation Count: 4
Association of lipoprotein(a) concentration and apo(a) isoform size with restenosis after percutaneous transluminal coronary angioplasty
(Springer Verlag, 2000) Sırıkcı, Onder; Aytekin, Vedat; Demiroglu, I. C. C.; Demiroğlu, Cemşid; Marcovina, S.M.
Lp(a) is a unique class of lipoprotein particles that exhibits a considerable size heterogeneity resulting from the size polymorphism of apo(a) its unique protein component. An elevated level of Lp(a) in plasma has been proposed to be a risk factor for premature development of coronary artery disease. To evaluate the relationship between Lp(a) concentration and apo(a) isoform size with restenosis after percutaneous transluminal coronary angioplasty Lp(a) levels and apo(a) phenotypes were determined in 204 patients who underwent a successful coronary angioplasty procedure and stent implantation. The patients were followed with clinical examinations and exercise tests at 1 3 and 6 months and a control coronary angiography was performed after 6 months to evaluate restenosis. Lp(a) levels were determined with an ELISA that is insensitive to the size heterogeneity of Lp(a) and the apo(a) isoforms were determined by a high-resolution agarose gel electrophoresis method followed by immunoblotting with a specific monoclonal antibody. Of the 146 patients who underwent angiographic evaluation 57 (39%) had restenosis whereas 89 (61%) did not. Lp(a) levels and the distribution of the expressed apo(a) phenotypes were compared in these two groups of patients. Although the mean and median Lp(a) levels were higher in the restenosed group the difference was not statistically significant. However a significant difference in Lp(a) values was found in women (P=0.043) even though because of the small number of women in the study (n=35) no sound conclusions can be reached on the predictive role of Lp(a) in restenosis. There also was no difference in the distribution of apo(a) phenotypes between the two groups. Because of their wide distribution Lp(a) values and apo(a) isoforms do not seem to be a useful indicator of risk of restenosis after percutaneous transluminal coronary angioplasty in our study cohort.
Citation Count: 0
C-reactive protein as a pre-procedural predictor of early and late outcomes of coronary angioplasty and intracoronary stent placement
(W.B. Saunders Co Ltd, 2001) Aytekin, Vedat; Aytekin, Saide; Çatakoğlu, Alp Burak; Kocazeybek, Bekir Sami; Demiroğlu, I. C. Cemşid; Demiroğlu, C
[Abstract Not Available]
Citation Count: 2
C-reactive protein as a pre-procedural predictor of early and late outcomes of percutaneous coronary interventions
(Springer New York, 2003) Aytekin, Saide; Çatakoğlu, Alp Burak; Aytekin, Vedat; Demiroğlu, Cemşid; Kocazeybek, Bekir Sami
To examine the predictive value of pre-procedural CRP level in patients undergoing percutaneous coronary intervention (PCI) regardless of having unstable or stable angina pectoris or myocardial infarction. Blood sampling for CRP measurement in patients undergoing PCI: 116 consecutive patients who underwent single vessel PCI were evaluated. Exclusion criteria were multilesion PCI, total occlusion, left ventricular ejection fraction < 30%, left bundle branch block and intercurrent inflammatory conditions known to be associated with an acute phase response. Major adverse coronary events (MACE) were defined as the occurrence of death, fatal or nonfatal myocardial infarction, and need for coronary artery revascularization with either bypass grafting or repeat angioplasty. End-points were assessed at hospital discharge, 30 days, 3 and 6 months following the index procedure. 62 (53%) patients had CRP levels < 0.5 mg/dl, and 54 (47%) had > 0.5 mg/dl. There were no significant difference in the occurrence of MACE in early in-hospital and 30 days follow up periods, between the two groups (0 vs. 5.5%) (p = ns) whereas the incidence of MACE after 3 months of the procedure was significantly different between the two groups (1.6 vs. 11%) (p < 0.05) and also after 6 months (9.5 vs 24.5%) (p < 0.05). The negative predictive value of CRP measurement is 98.4%. High levels of pre-procedural CRP show association with the higher incidence of MACE after 3 months of the follow-up period and negative CRP tests seems to have high predictive value to compare the patients who will be free of MACE after successful PCI. SciVal Topic Prominence
Citation Count: 0
[The effects of phase II cardiac rehabilitation programme on patients undergone coronary bypass surgery]
(2005) Çiftçi, Çavlan; Süsleyici Duman, Belgin; Çağatay, Penbe; Demiroğlu, Cemşid; Aytekin, Vedat
Objective: To investigate the effects of phase II cardiac rehabilitation in 52 patients undergone coronary artery bypass surgery. Methods: Gradual walking tests, cardio-pulmonary capacity tests and lipid profile were administered to patients selected for phase II cardiac rehabilitation before and after the programme. Training was started on 12-channel electrocardiogram controlled running bands 3 times a week for 20 min periods for 12 weeks fitting the programme. Low or intermediate level exercise programme was applied to patients. Cleveland Clinic Chronotropic Assessment exercise protocol was used during rehabilitation. Results: As a result of phase II cardiac rehabilitation administered to 52 patients undergone coronary bypass operation, exercise capacity, oxygen consumption, anaerobic threshold, cardiac output mean values (p<0.001) and mean HDL cholesterol level (p<0.05) were found to increase, whereas body mass index, total cholesterol, LDL cholesterol and triglyceride mean levels reduced (p<0.001) significantly. Conclusion: In patients who have undergone coronary bypass surgery, phase II cardiac rehabilitation is a very useful programme in improvement of life quality and secondary prevention.
Citation Count: 1
Is package pricing in favor of patients or institutions?
(Turkish Soc Cardiology, 2005) Aytekin, Vedat
[Abstract Not Available]
Citation Count: 0
Koroner baypas geçiren olgularda faz II kardiyak rehabilitasyon programının etkileri
(Türk Kardiyoloji Derneği / Kare Yayıncılık, 2005) Çiftçi, Çavlan; Süsleyici Duman, Belgin; Çağatay, Pembe; Demiroğlu, Cemşid; Aytekin, Vedat
Amaç: Koroner arter cerrahisi geçiren 52 hastaya uygulanan Faz II kardiyak rehabilitasyonun etkilerini araştırılmaktadır. Yöntemler: Faz II kardiyak rehabilitasyona al›nan hastalara bu program öncesinde ve sonunda; dereceli yürüme testleri, kalp-akciğer kapasite testleri, lipid profili yapıldı. Programa uygun olarak 12 hafta boyunca haftada 3 kez 20 dakika süreli seanslar şeklinde, 12 kanal elektrokardiyografi kontrolünde koşu bandında egzersiz antrenmanları yapıldı. Hastalara düşük veya orta yoğunluklu egzersiz program› verildi. Rehabilitasyon süresince Cleveland Clinic Chronotropic Assessment egzersiz protokolu uygulandı. Bulgular: Koroner baypas operasyonu geçirmifl 52 hastaya uygulanan Faz II kardiyak rehabilitasyon sonunda hastalar›n efor kapasitesi, oksijen tüketimi, anaerobik eflik, kalp debisi ortalama de¤erlerinde anlamlı artma (p£0.001), HDL-kolesterol ortalama de¤erinde anlamlı artma (p£0.05) ve beden kitle indeksi (BKİ), total-kolesterol, LDL-kolesterol, trigliserid ortalama rakamlarında anlamlı azalma (p£0,001) tespit edildi. Sonuç: Koroner arter cerrahisi geçiren hastalarda Faz II kardiyak rehabilitasyon, yaşam kalitesi ve ikincil korunma açısından çok yararIı bir programdır. (Anadolu Kardiyol Derg 2005; 5: 116-21)
Citation Count: 2
A left pulmonary artery aneurysm secondary to pulmonary hypertension
(2001) Sönmez, Bingür; Tansal, Selim; Ünal, Mehmet; Korkut, Ali Kubilay; Yağan, Naci Erciyes; Demirsoy, Ergun; Arbatlı, Harun; Aytekin, Vedat
We report a case of pulmonary trunk aneurysm extending into the left pulmonary artery due to pulmonary hypertension secondary to mitral valve disease. The mitral valve was replaced with a bileaflet mechanical prosthesis. A Dacron graft interposed between main trunk and left pulmonary artery branch and right pulmonary branch attached to the graft in an end-to-side fashion. Early postoperative angiogram revealed a very successful treatment.
Citation Count: 17
Off-pump coronary artery bypass grafting with use of the octopus 2 stabilization system
(2000) Akpınar, Belhhan; Güden, Mustafa; Sağbaş, Ertan; Sanisoğlu, İlhan; Aytekin, Vedat; Bayındır, Osman
Background: The treatment of coronary artery disease has evolved rapidly over the last two decades. The gold standard of surgical revascularization, the on-pump coronary artery bypass graft, has been challenged by the development of percutaneous transluminal coronary angioplasty. Our experience with the alternative of the off-pump ("beating heart") coronary artery bypass (OPCAB) technique during a period of 18 months suggests that OPCAB avoids the complications of cardiopulmonary bypass and offers patients the benefit of long-term graft patency that greatly exceeds that of current endovascular technologies. Methods: The early results of 126 OPCAB procedures performed through a medial sternotomy incision during a period of 18 months were evaluated. There were 80 male and 46 female patients, with a mean age of 69 +/- 4.3 years. Emergency cases and reoperations were not included. A total of 268 anastomoses were performed, with a mean number of 2.12 anastomoses per patient. Conduits used, with their percentage of use, were: left internal thoracic artery (LITA) (100%), right internal thoracic artery (11.1%), greater saphenous vein (84%), and radial artery (31%). In 72% of the cases, off-pump surgery was chosen because of patient risk factors such as atherosclerotic aortic disease, previous cerebrovascular accident or carotid artery disease, renal dysfunction, malignancy or poor left ventricular function. Results: There was no operative mortality. One-month postoperative mortality was three patients (2.3%). Two died because of mesenteric ischemia, and the other death was due to cardiac failure. Seventy-one patients had a control angiogram before discharge. The patency of LITA anastomosis was 100% while overall patency rate was 95%. In 43 patients for whom an angiogram could not be performed, a Thallum 201 stress test was performed three months postoperatively. Thirty-eight patients had a normal test while five patients showed signs of ischemia. These patients had a control angiogram: in four patients anastomoses were patent, but in one patient there was a severe narrowing of a venous anastomosis to the distal right coronary artery (RCA) which was corrected with angioplasty. In the whole series eight patients (6.3%) refused to have any control examination. Conclusions: Our early results suggest that off-pump CABG with Octopus 2 (Medtronic, Inc., Minneapolis, MN) can be a good alternative in high risk patients who need multiple vessel revascularization.
Citation Count: 0
Paket fiyat uygulamaları hastayı mı, kurumları mı korumaktadır?
(Kare Yayıncılık, 2005) Aytekin, Vedat
[Abstract Not Available]
Citation Count: 0
Thrombosed giant right coronary artery aneurysm
(TÜRK KARDİYOLOJİ DERNEĞİ / KARE YAYINCILIK, 2007) Çelebi, Hüseyin; Duran, Cihan; Çatakoğlu, Alp Burak; Gülbaran, Murat; Demiroğlu, Cemşid; Aytekin, Vedat
[Abstract Not Available]