Browsing by Author "Demir, Tamer"

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Investigation the Risk of Autism by Evaluating Prenatal and Postnatal Exposure To Traffic-Related Air Pollution
(Kadir Has Üniversitesi, 2020) Demir, Tamer; Dağ, Tamer
Autism spectrum disorder (ASD ) which is a group of neurodevelopmental disorder that appears during the first few years of a child's life affecting a child's communication and socialization abilities with increasing prevalence. Recently, several recent studies have found associations between exposure to traffic-related air pollution (TRAP) and ASD. The primary aim of this study is to investigate/examine the relation between TRAP and four air pollutants (NO2, O3, PM10, PM2.5) and ASD during prenatal or post-natal by using multiple logistic regression models and variable selection methods. Results show that the adjusted odds ratio (AOR) for ASD per IQR increase was strongly associated for exposure to NO2 during the first year period, was moderately associated for exposure to NO2 (from interstate highways during the third trimester; from the county highway during the first year; from city street during the first year; from all roads during the all pregnancy; from all roads during the first trimester) and O3 during the second year, and weakly associated with exposure to NO2 from interstate highways during the second trimester, O3 during the first trimester and PM2.5 during the second year. Additionally, comparing fourth to first quartile exposures the AOR was 15.47 for NO2 from interstate highways during the third trimester, was 5.00 for NO2 from all roads during the first trimester, and comparing third to first quartile exposures the AOR was 2.31 for PM2.5 during the second year. As a result, a strong relationship between NO2 exposure and ASD was detected for each 7.1 ppb [IQR] increase in NO2 during the first year and subjects exposed to a higher level of NO2 during the first and third trimester, and PM2.5 during the second year was also associated with increased risk of ASD.