Browsing by Author "Demirci, Seda"

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    Master Thesis
    Molacilar Dynamics Studies Oh Human Dat and Its Natural Ligand Dopamine
    (Kadir Has Üniversitesi, 2012) Demirci, Seda; Özal, Tuğba Arzu
    The dopamine transporter (DAT) which is a member of Neurotransmitter sodium symporters (NSSs) family takes place in dopaminergic neurotransmission. Therefore it is a major molecular target for numerous drugs including the widely abused psychostimulants cocaine and amphetamine as well as antidepressants. in this study to understand the dynamics behavior of structure-function relationship of the human dopamine transporter (DAT) we performed MD studies. The dopamine DAT interactions were investigated via Molecular Dynamics (MD) simulations combined with docking analysis. -- Abstract'tan.