Mühendislik ve Doğa Bilimleri Fakültesi

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Citation Count: 0
"2-pirazolin yapısındaki yeni bir bileşiğin sentezi, moleküler modellemesi ve monoaminoksidaz inhibitörü etkisinin araştırılması"
(Türkiye Halk Sağlığı Kurumu, 2018) Yelekçi, Kemal; Uçar, Gülberk; Yelekçi, Kemal
Amaç: Nöromediatörlerin yıkımından sorumlu olan monoamin oksidaz (MAO) enziminin izoformlarının (MAO-A ve -B) birçok hastalık ile yakından ilişkili olduğu; MAO inhibitörlerinin depresyon, Parkinson ve Alzheimer hastalığı gibi hastalıkların tedavisinde kullanıldığı bilinmektedir. Grubumuzca daha etkin, tersinir ve az yan etkili yeni bir MAO inhibitörü (SH2U bileşiği) sentezlenmiş ve bu bileşiğin insan MAO enzimini (hMAO) inhibe etme yeteneği incelenmiştir. Ayrıca bu yeni bileşiğin hMAO ile etkileşimi, moleküler modelleme çalışmaları ile detaylı bir şekilde araştırılmıştır. Sentezlenen yeni bileşiğin hMAO’yu kuvvetli bir şekilde yarışmalı ve tersinir olarak inhibe ettiği bulunmuştur. Söz konusu bileşiğin Parkinson ve Alzheimer hastalıklarının tedavisinde ümit verici bir ilaç etken maddesi olabileceği düşünülmektedir. Yöntem: 3’,5’-Dikloro-2’-hidroksi asetofenon ile p-tolualdehit’in metanol içinde KOH varlığında reaksiyona girmesiyle 1-(3,5-dikloro-2-hidroksifenil)- 3-p-tolil prop-2-en-1-on (3’,5’-Dikloro-2’-hidroksi-4- metil şalkon) bileşiği sentez edilmiştir. Daha sonra elde edilen bu bileşiğin etanol içerisinde geri çeviren soğutucu altında izonikotinik asit hidrazit ile muamele edilmesiyle [3-(3,5-dikloro-2-hidroksifenil)-5-p-tolil-4,5- dihidropirazol-1-il] (piridin-4-il) metanon bileşiği sentez edilmiştir. Yapısı doğrulanan bu bileşiğin hMAO enzimi ile etkileşimi, ticari tayin kiti kullanılarak fluorometrik bir yöntemle incelenmiştir. Ayrıca, söz konusu yeni bileşik ile hMAO arasındaki etkileşimler, moleküler modelleme çalışmaları ile aydınlatılmıştır. Bulgular: Sentezlenen bileşiğin yapısı, IR, Mass, 1H-NMR ve elemental analiz yöntemleri kullanılarak doğrulanmıştır. Yapısı doğrulanan bu bileşiğin etkin, seçici, tersinir, toksik olmayan bir hMAO-B inhibitörü olduğu ve inhibisyonun yarışmalı olduğu görülmüştür. Moleküler yerleştirme programı kullanılarak bileşiğin hMAO-B enziminin aktif bölgesinde hangi amino asit yan zincirleri ile ne tür girişimleri yaptığı belirlenmiştir. Sonuç: Yeni sentezlenen SH2U bileşiği, hMAO-B enzimini kuvvetle, seçici, yarışmalı ve tersinir olarak inhibe etmiştir. Sentezlediğimiz bileşik, bilinen seçici ama tersinmez MAO-B inhibitörü olan selejilin’den daha etkin ve seçici, tersinir olarak hMAO-B enzimini inhibe etmiştir ve Parkinson ile Alzheimer hastalığı tedavisinde kullanılabilecek bir ilaç etken maddesi olarak ümit vadetmektedir.
Citation Count: 0
The Association of Gvhd With Hla Dr Alleles, Ifn-Gamma, Tgf-Beta, And Mbl2 Gene Polymorphism
(Wiley, 2019) Oğuz, Rusdu; Çiftçi, Hayriye Şentürk; Gökçe, Muge; Öğret, Yeliz; Karadeniz, Sedat Tanju; Pehlivan, Sacide; Aydın, Filiz
[Abstract Not Available]
Citation Count: 1
A Bayesian approach to developing a strategic early warning system for the French milk market
(Halmstad University, 2017) Bisson, Christophe; Gürpınar, Furkan
A new approach is provided in our paper for creating a strategic early warning system allowing the estimation of the future state of the milk market as scenarios. This is in line with the recent call from the EU commission for tools that help to better address such a highly volatile market. We applied different multivariate time series regression and Bayesian networks on a pre-determined map of relations between macro-economic indicators. The evaluation of our findings with root mean square error (RMSE) performance score enhances the robustness of the prediction model constructed. Our model could be used by competitive intelligence teams to obtain sharper scenarios, leading companies and public organisations to better anticipate market changes and make more robust decisions.
Citation Count: 4
Broadband Equalizer Design with Commensurate Transmission Lines via Reflectance Modeling
(IEICE-INST ELECTRONICS INFORMATION COMMUNICATIONS ENG, 2008) Şengül, Metin Y.; Yarman, Sıddık Binboğa
In this paper an alternative approach is presented to design equalizers (or matching networks) with commensurate (or equal length) transmission lines. The new method automatically yields the matching network topology with characteristic impedances of the commensurate lines. In the implementation process of the new technique first the driving point impedance data of the matching network is generated by tracing a pre-selected transducer power gain shape without optimization. Then it is modelled its it realizable bounded-real input reflection coefficient in Richard domain which ill turn yields the desired equalizer topology with line characteristic impedances. This process results in an excellent initial design for the commercially available computer aided design (CAD) packages to generate final circuit layout for fabrication. An example is given to illustrate the utilization of the new method. It is expected that the proposed design technique is employed as it front-end to commercially available computer aided design (CAD) packages which generate the actual equalizer circuit layout with physical dimensions for mass production.
Citation Count: 10
Competitive intelligence and information technology adoption of SMEs in Turkey: Diagnosing current performance and identifying barriers
(Halmstad University, 2013) Wright, Sheila; Bisson, Christophe; Duffy, Alistair P.
The need for SMEs to behave in a more concise and coherent competitive fashion is well recognised. This study reports on an empirical study of SMEs in Turkey. Their responses were applied to a behavioural and information technology adoption framework which enabled the identification of areas where changes would be required for these firms to begin operating at a higher level of competence. The findings revealed significant scope for improvements on all strands of the diagnostic framework: attitude gathering location technology support IT systems support and finally use of intelligence-based output by decision-makers. Through free form responses it was also possible to identify barrier to higher level adoption and performance inhibiters which were subsequently categorised and assessed for significance.
Citation Count: 4
Design and implementation of a negative feedback oscillator circuit based on a Cellular Neural Network with an Opposite Sign Template
(2010) Özmen, Atilla; Tander, Baran; Özçelep, Yasin
In this paper explicit amplitude and frequency expressions for a Cellular Neural Network with an Opposite-Sign Template (CNN-OST) under oscillation condition are derived and a novel inductorless oscillator circuit with negative feedbacks based on this simple structure is designed and implemented. The system is capable of generating quasi-sine signals with tuneable amplitude and frequency which can't be provided at the same time in the classical oscillator circuits.
Citation Count: 3
Elasticity Study of PAAm-kappa C Composite Prepared in Various kappa C Content and Measured at Several Temperatures
(Polish Acad Sciences Inst Physics, 2015) Evingür, Gülşen Akin; Pekcan, Önder
Polyacrylamide (PAAm)-kappa carrageenan (kappa C) composite gels were prepared via free radical crosslinking copolymerization with various (w/v) percentages of kappa C in the range between 0.5 and 3 (w/v)% of kappa C . Elasticity properties such as stress strain and compressive elastic modulus S of these composite gels were studied in various kappa C content and at several temperatures. The content and temperature dependence of the compressive elastic modulus S of the swollen PAAm-kappa C composite gels due to volume phase transition were produced by using tensile testing technique. It is understood that the compressive elastic modulus was found to decrease up to 1 (w/v)% of kappa C and then increase by increasing kappa C contents at constant temperatures. The composite preserves the ability to undergo the volume phase transition and its compressive elastic modulus is found to be strongly dependent on the kappa C content and temperature. It is observed that the compressive elastic modulus increased when temperature is increased up to 40 degrees C and then decreases below this temperature for all composite gels. However PAAm-kappa C composite gel presented lower values for the compressive elastic modulus showing a minima at 40 degrees C for 1 (w/v)% of kappa C content gel.
Citation Count: 2
Fractal Features and Structural Morphological Optical Characteristics of Sol-Gel Derived Silica Nanoparticled Thin Films
(Polish Acad Sciences Inst Physics, 2018) Uysal, Bengü Özuğur; Pekcan, Önder
Nanostructured silica films using a simple and effective sol-gel spin coating technique were synthesized and the influence of ammonia/sol ratios on the particle size and thickness of this film was investigated. In addition fractal dimensions of the prepared films were determined using the scattering response technique. The samples were characterized by atomic force microscopy and UV-vis spectroscopy. Comparing optical method and image analysis of atomic force microscopy micrographs the fractal dimension of silica nanoparticled thin films was determined. The fractal dimensions of the films verified by atomic force microscopy analysis were found to be around 2.03 which is very close to the values (2.0358 2.0325 and 2.0335) obtained using optical method. As a result of these findings precise determination of the nanoparticled silica thin films fractal dimension using both optical and surface analysis methods was realized.
Citation Count: 1
Fuzzy-neural networks for medical diagnosis
(2010) Şenol, Canan; Yıldırım, Tülay
In this paper a novel fuzzy-neural network architecture is proposed and the algorithm is developed. Using this new architecture fuzzy-CSFNN fuzzy-MLP and fuzzy-RBF configurations were constituted and their performances have been compared on medical diagnosis problems. Here conic section function neural network (CSFNN) is also a hybrid neural network structure that unifies the propagation rules of multilayer perceptron (MLP) and radial basis function (RBF) neural networks at a unique network by its distinctive propagation rules. That means CSFNNs accommodate MLPs and RBFs in its own self-network structure. The proposed hybrid fuzzy-neural networks were implemented in a well-known benchmark medical problems with real clinical data for thyroid disorders breast cancer and diabetes disease diagnosis. Simulation results show that proposed hybrid structures outperform both MATLAB-ANFIS and non-hybrid structures. © 2010 Inderscience Enterprises Ltd.
Citation Count: 0
Joint data detection and channel estimation for uplink MC-CDMA systems over frequency selective channels
(Springer, 2007) Panayırcı, Erdal; Doğan, Hakan; Çırpan, Hakan Ali; Fleury, Bernard Henri
This paper is concerned with joint channel estimation and data detection for uplink multicarrier code-division multiple-access (MC-CDMA) systems ill the presence of frequency fading channel. The detection and estimation implemented at the receiver are based on a version of the expectation maximization (EM) algorithm which is very suitable for the the multicarrier signal formats. Application of the EM-based algorithm to the problem of iterative data detection and channel estimation leads to a receiver structure that also incorporates a partial interference cancelation. Computer simulations show that the proposed algorithm has excellent BER end estimation performance.
Citation Count: 4
PAAm-kappa carrageenan composites: drying and swelling with various kappa carrageenan contents
(Polish Acad Sciences Inst Physics, 2012) Akın-Evingür, Gülşen; Pekcan, Önder
The purpose of this study is to discuss the role of kappa-carrageenan (kappa-car) in the drying and swelling of polyacrylamide (PAAm)-kappa-car composite. The fluorescence intensity of pyranine increased and decreased as drying and swelling time were increased respectively for all samples. The desorption coefficient D-d decreased as kappa-car contents were increased for a given temperature during drying. However cooperative diffusion coefficient D-s increased as kappa-car contents were increased during swelling at a given temperature.
Citation Count: 0
Rapidly Varying Sparse Channel Tracking with Hybrid Kalman-OMP Algorithm
(Springer, 2019) Şenol, Habib; Erküçük, Serhat; Erküçük, Serhat; Cirpan, Hakan Ali
It is expected from future communication standards that channel estimation algorithms should be able to operate over very fast varying frequency selective channel models. Therefore in this study autoregressive (AR) modeled fast varying channel has been considered and tracked with Kalman filter over one orthogonal frequency division multiplexing (OFDM) symbol. Channel sparsity is exploited which decreases the complexity requirements of the Kalman algorithm. Since Kalman filter is not directly applicable to sparse channels orthogonal matching pursuit (OMP) algorithm is modified for AR modeled sparse signal estimation. Also by using windows sparsity detection errors have been decreased. The simulation results showed that sparse fast varying channel can be tracked with the proposed hybrid Kalman-OMP algorithm and windowing method offers improved MSE results.
Citation Count: 3
Universality of elasticity on PAAM-NIPA copolymer gels
(EDP Sciences, 2015) Evingür, Gülşen Akin; Pekcan, Önder
Polyacrylamide (PAAm)-N-isopropylacrylamide (NIPA) copolymers were prepared via free radical crosslinking copolymerization with different molar of NIPA varying in the range between 0 and 2 M. The mechanical properties of swollen PAAm-NIPA copolymers were characterized by the compressive testing technique. It is understood that the compressive elastic modulus was found to increase by increasing NIPA contents keeping temperature constant at 30 degrees C. The critical exponent of elasticity y above the critical NIPA concentration is found to be as 0.74 which is consistent with the suggestions of percolation for superelastic percolation network (SEPN) and the critical theory for PAAm-NIPA copolymers.

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