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Citation Count: 0
2nd tourism and hospitality networking conference | RESNET’22
(Routledge, 2023) Serra, J.
[No abstract available]
Citation Count: 5
(3+3+2) warped-like product manifolds with Spin(7) holonomy
(Elsevier Science Bv, 2011) Bilge, Ayşe Hümeyra; Bilge, Ayşe Hümeyra
We consider a generalization of eight-dimensional multiply warped product manifolds as a special warped product by allowing the fiber metric to be non-block diagonal. We define this special warped product as a (3 + 3 + 2) warped-like manifold of the form M = F x B. where the base B is a two-dimensional Riemannian manifold and the fibre F is of the form F = F-1 x F-2 where the F-i(i = 1 2) are Riemannian 3-manifolds. We prove that the connection on M is completely determined by the requirement that the Bonan 4-form given in the work of Yasui and Ootsuka [Y. Yasui and T. Ootsuka Spin(7) holonomy manifold and superconnection Class. Quantum Gravity 18(2001)807-816] be closed. Assuming that the F-i are complete connected and simply connected it follows that they are isometric to S-3 with constant curvature k > 0 and the Yasui-Ootsuka solution is unique in the class of (3 + 3 + 2) warped-like product metrics admitting a specific Spin(7) structure. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
Citation Count: 4
3D indoor positioning with spatial modulation for visible light communications
(Elsevier, 2023) Arsan, Taner; Yesilirmak, Yalin Evrim; Bayman, Irem Ozgur; Arsan, Taner; Panayırcı, Erdal; Stevens, Nobby
In this paper, a novel three-dimensional (3D) indoor visible light positioning (VLP) algorithm is proposed based on the spatial modulation (SM) and its error performance assessed as compared to the conventional received signal strength (RSS)-based 3D VLP systems. As contrasted to the traditional VLP system, the proposed SM-based 3D VLP system first estimates the optical channel gain between the transmitting light-emitting diodes (LEDs) and the two photo detectors (PDs) attached to the user by a pilot-based channel estimation technique. Then, unknown 3D positions of the receiver are determined by the trilateration algorithm with distances computed from the estimates of the channel gains. Consequently, the 3D VLP system achieves an interference -free transmission with increased spectral efficiency and without the need for a demultiplexing process at the receiving end. The algorithm's performance is evaluated regarding positioning error by applying the SM over four LEDs and the number of pilots selected as a function of the environmental signal-to-noise ratios (SNRs). The computer simulation results show that the positioning errors are obtained in an order of magnitude smaller than RSS-based techniques in an indoor industrial environment. This is mainly because the distances involved in determining the 3D positions can be determined more precisely by the pilot-aided channel estimation method without creating any data rate problem in transmission due to the higher spectral efficiency of the SM.
Citation Count: 2
3D Printer Selection for the Sustainable Manufacturing Industry Using an Integrated Decision-Making Model Based on Dombi Operators in the Fermatean Fuzzy Environment
(Mdpi, 2024) Görçün, Ömer Faruk; Zolfani, Sarfaraz Hashemkhani; Kucukonder, Hande; Antucheviciene, Jurgita; Pavlovskis, Miroslavas
Three-dimensional printers (3DPs), as critical parts of additive manufacturing (AM), are state-of-the-art technologies that can help practitioners with digital transformation in production processes. Three-dimensional printer performance mostly depends on good integration with artificial intelligence (AI) to outperform humans in overcoming complex tasks using 3DPs equipped with AI technology, particularly in producing an object with no smooth surface and a standard geometric shape. Hence, 3DPs also provide an opportunity to improve engineering applications in manufacturing processes. As a result, AM can create more sustainable production systems, protect the environment, and reduce external costs arising from industries' production activities. Nonetheless, practitioners do not have sufficient willingness since this kind of transformation in production processes is a crucial and irrevocable decision requiring vast knowledge and experience. Thus, presenting a methodological frame and a roadmap may help decision-makers take more responsibility for accelerating the digital transformation of production processes. The current study aims to fill the literature's critical theoretical and managerial gaps. Therefore, it suggests a powerful and efficient decision model for solving 3DP selection problems for industries. The suggested hybrid FF model combines the Fermatean Fuzzy Stepwise Weight Assessment Ratio Analysis (FF-SWARA) and the Fermatean Ranking of Alternatives through Functional mapping of criterion sub-intervals into a Single Interval (FF-RAFSI) approaches. The novel FF framework is employed to solve a critical problem encountered in the automobile manufacturing industry with the help of two related case studies. In addition, the criteria are identified and categorized regarding their influence degrees using a group decision approach based on an extended form of the Delphi with the aid of the Fermatean fuzzy sets. According to the conclusions of the analysis, the criteria "Accuracy" and "Quality" are the most effective measures. Also, the suggested hybrid model and its outcomes were tested by executing robustness and validation checks. The results of the analyses prove that the suggested integrated framework is a robust and practical decision-making tool.
Citation Count: 0
3D self-assemble formation of molybdenum disulfide $(MoS_2 )-doped$ polyacrylamide (PAAm) composite hydrogels
(2022) Durmaz, Sümeyye; Yıldız, Ekrem; Uysal, Bengü Özuğur; Pekcan, Önder
Polyacrylamide (PAAm), a renowned member of the hydrogel class, has many uses throughout a wide range of industrial processes, including water absorbed diapers, contact lenses, wastewater treatment, biomedical applications such as drug delivery vehicles and tissue engineering because of its physical stability, durability, flexibility easier shaping, and so on. PAAm also provides new functionalities after the incorporation of inorganic structures such as molybdenum disulfide $(MoS_2 )$. During the copolymerization process, the transmittance of all samples reduced significantly after a particular time, referred to as the gel point. Microgels form a tree above the gel point as projected by Flory-Stockmayer classical theory. Because of microgels positioned at the junction points of the Cayley tree, the addition of $MoS_2$ results in strong intramolecular crosslinking and looser composites. Moreover, fractal geometry provides a quantitative measure of randomness and thus permits characterization of random systems such as polymers. Fractal dimension of these polymer composites is calculated from power-law-dependent scattered intensity. It was also confirmed that a hydrogel rapidly formed within a few seconds, indicating a 3D network formation inside the gel. These materials may have a great potential for application in wearable and implantable electronics due to this highly desired 3D self-assemble feature.
Citation Count: 1
3D-printed actuator-based beam-steering approach for improved physical layer security in visible light communication
(Optica Publishing Group, 2022) Erdem, Mehmet Can; Gurcuoglu, Oguz; Panayırcı, Erdal; Kurt, Gunes Karabulut; Ferhanoglu, Onur
In this study, we present the design, manufacture, and implementation of a 3D-printed lens scanner-based beam steering for use in visible light communication (VLC) applications. The 5 cm x 5 cm scanner is designed for low-cost 3D printing with fused deposition modeling using polylactic acid. Scanning is facilitated through electromagnetic actuation of the lens frame, carrying a conventional 25 mm lens, from two nearly orthogonal directions. The serpentine spring that connects the lens frame to the external frame is tailored to offer similar spring constants in the directions of actuation and has minimal (<1.5 mm) sag due to the mass of the lens. The manufactured actuator was integrated on a miniaturized VLC test bed (70 cm x 40 cm x 40 cm). Using the test bed, we characterized the applied voltage versus beam displacement behavior of the actuator in the lateral plane and demonstrated beam steering on amoving target with face-recognition feedback. The proposed scheme was targeted to offer an improved security measure in VLC through tracking the legitimate receiver (i.e., via face recognition) and uses the feedback to steer the focused light onto the targeted device. The joint use of focusing and steering features allows for the legitimate receiver to roam within the room while enjoying the improved secrecy due to the focused light. We calculate the secrecy capacity for the demonstrated approach, which compares favorably with a number of jamming, spatial modulation, and beam-forming counterparts. The presented actuator can be used with larger room dimensions, yet upscaling to larger illumination units will require the use of a lens having smaller focus to address a larger total steering angle. (C) 2022 Optica Publishing Group
Citation Count: 1
ABD’nin Levant Hengamesinde Süreklenen Politikaları
(2018) Özel, Soli; Özel, Soli
Levant bölgesi, İkinci Dünya Savaşı’ndan bu yana ABD dış politikasının öncelikli çıkar alanlarından birini oluşturmaktadır. Bu makalenin amacı, ABD’nin, bilhassa da son iki Amerikan yönetiminin, Levant’a yönelik politikalarını açıklığa kavuşturmayı, bölgede ve Amerikan siyasetindeki değişimlerin Washington’un Levant’a yönelik politikasının nasıl yanlı, zaman zaman beceriksiz ve daha da önemlisi tutarsız görünmesine neden olduğunu anlamayı hedeflemektedir. Makale, bir yönetimden diğerine İsrail’in egemenliğinin korunması, dostane rejimlerin desteklenmesi, terörizmle mücadele ve İran’ın kontrol altına alınması gibi konularda ve genel itibariyle bölgeye yönelik yaklaşımdaki değişiklikleri incelemektedir. Suriye’ye yönelik politikadaki tereddütler ve değişimler daha detaylı ele alınmıştır. Nitekim bu konular Amerika’nın Levant’a yönelik politikasının henüz son halini almadığının, daha da ötesinde gelişmeler karşısında ABD’nin nasıl yön değiştirdiğini ve Esad’ı yerinden etme hedefinden uzaklaşarak İran’ı kontrol altına alma ve eğer mümkünse boyun eğdirmeye odaklandığına işaret etmektedir.
Citation Count: 3
Abortion services at hospitals in Istanbul
(Taylor & Francis Ltd, 2017) O'Neil, Mary Lou
Objective: Despite the existence of a liberal law on abortion in Turkey there is growing evidence that actually securing an abortion in Istanbul may prove difficult. This study aimed to determine whether or not state hospitals and private hospitals that accept state health insurance in Istanbul are providing abortion services and for what indications. Method: Between October and December 2015 a mystery patient telephone survey of 154 hospitals 43 public and 111 private in Istanbul was conducted. Results: 14% of the state hospitals in Istanbul perform abortions without restriction as to reason provided in the current law while 60% provide the service if there is a medical necessity. A quarter of state hospitals in Istanbul do not provide abortion services at all. 48.6% of private hospitals that accept the state health insurance also provide for abortion without restriction while 10% do not provide abortion services under any circumstances. Key conclusions: State and private hospitals in Istanbul are not providing abortion services to the full extent allowed under the law. The low numbers of state hospitals offering abortions without restriction indicates a de facto privatization of the service. This same trend is also visible in many private hospitals partnering with the state that do not provide abortion care. While many women may choose a private provider the lack of provision of abortion care at state hospitals and those private hospitals working with the state leaves women little option but to purchase these services from private providers at some times subtantial costs.
Citation Count: 18
Absolute configuration and biological profile of pyrazoline enantiomers as MAO inhibitory activity
(Wiley, 2019) Yelekçi, Kemal; Sarıgül, Sevgi; Bultinck, Patrick; Herrebout, Wouter; Doğan, İlknur; Yelekçi, Kemal; Uçar, Gülberk; Kelekçi, Nesrin Gökhan
A new racemic pyrazoline derivative was synthesized and resolved to its enantiomers using analytic and semipreparative high-pressure liquid chromatography. The absolute configuration of both fractions was established using vibrational circular dichroism. The in vitro monoamine oxidase (MAO) inhibitory profiles were evaluated for the racemate and both enantiomers separately for the two isoforms of the enzyme. The racemic compound and both enantiomers were found to inhibit hMAO-A selectively and competitively. In particular the R enantiomer was detected as an exceptionally potent and a selective MAO-A inhibitor (K-i = 0.85 x 10(-3) +/- 0.05 x 10(-3) mu M and SI: 2.35 x 10(-5)) whereas S was determined as poorer compound than R in terms of K-i and SI (0.184 +/- 0.007 and 0.001). The selectivity of the enantiomers was explained by molecular modeling docking studies based on the PDB enzymatic models of MAO isoforms.
Citation Count: 0
Adölesan idiyopatik skolyozun anterior enstrümantasyon ile tedavisi ve erken sonuçlar
(Türk Ortopedi ve Travmatoloji Derneği, 2001) Göğüş, Abdullah; Akman, Şenol; Talu, Ufuk; Şar, Cüneyt; Hamzaoğlu, Azmi
Amaç: Üçüncü kuşak anterior vida;tek çubuk sistemleri ve intervertebral titanyum mesh kullanılarak tedavi edilen adölesan idiopatik skolyozlu olgularda erken dönem tedavi sonuçları değerlendirildi. Çalışma planı: Adölesan idiopatik skolyozlu 17 hasta (15 kadın, 2 erkek; ort. Yaş 14.9:dağılım 11-20) değerlendirildi. Eğrilikler dört olguda King tip I, altı olguda tip II, iki olguda tip III, iki olguda tip IV ve üç olguda lomber olarak sınıflandırıldı. Lomber olgularda tüm seviyelerde, torakal olgularda ise enstrümantasyonun kranial ve kaudal sınırlarında intervertebral titanyum mesh$ler kullanıldı. Tüm olgular ameliyat sonrası 3-6 ay süreyle torakolumbosakral ortez içinde immobilize edildi. Hastaların ameliyat öncesi, ameliyat sonrası ve takiplerinde iki yönlü orthoröntgenografileri değerlendirildi. Ortalama takip süresi 28 ay (dağılım 18-41 ay) idi. Sonuçlar: Koronal eğrilik derecesi ortalamaları ameliyat öncesinde 51, ameliyat sonrasında 8.6 bulundu. Koreksiyon oranı ortalaması %83.9 idi. Ameliyat sonrası sagital açı değerleri ortalaması torakal kifoz için 27.5, lomberlordoz için 37.6 bulundu. Sekonder eğriliklerin hiçbirinde dekompensasyon gelişmedi. Posterior enstrümantasyon ile karşılaştırıldığında ortalama 0.93 seviye füzyondan tasarruf edildi. Torakolomber geçiş bölgesi kifozu saptanmadı. Bir torasik olguda vida sıyırması nedeniyle, erken dönemde posterior enstrümentasyon ile revizyon uygulandı. Takiplerde psödoartroz, implant yetersizliği ve koreksiyon kaybı gibi problemlerle karşılaşılmadı, Çıkarımlar: Sonuçlarımız üçüncü kuşak anterior tek çubuk enstrümentasyon ve intervertebral titanyum mesh'lerin adölesan idiopatik skolyozun cerrahi tedavisinde posterior enstrümentasyona iyi bir alternatif olduğunu gösterdi.
Citation Count: 11
An advanced Grey Wolf Optimization Algorithm and its application to planning problem in smart grids
(Springer, 2022) Ceylan, Oğuzhan; Younesi, Soheil; Ceylan, Oguzhan; Ozdemir, Aydogan
Due to the complex mathematical structures of the models in engineering, heuristic methods which do not require derivative are developed. This paper improves recently developed Grey Wolf Optimization Algorithm by extending it with three new features: namely presenting a new formulation for evaluating the positions of search agents, applying mirroring distance to the variables violating the limits, and proposing a dynamic decision approach for each agent either in exploration or exploitation phases. The performance of Advanced Grey Wolf Optimization (AGWO) method is tested using several optimization test functions and compared to several heuristic algorithms. Moreover, a planning problem in smart grids is solved by considering different objective functions using 33 and 141 bus distribution test systems. From the numerical simulation results, we observe that, AGWO is able to find the best results compared to other methods from 10 and 9 out of 13 test functions for 30 and 60 variables, respectively. Similar to this, it finds best function values for 5 out of 10 fixed number of variable test functions. Also, the result of the CEC-C06 2019 benchmark functions shows that AGWO outperforms 8 for optimization problems from 10. In power distribution system planning problem, better objective function values were determined by using AGWO, resulting a better voltage profile, less losses, and less emission costs compared to solutions obtained by Grey Wolf Optimization (GWO) and Particle Swarm Optimization (PSO) algorithms.
Citation Count: 0
Adverse selection in cryptocurrency markets
(Wiley, 2023) Tiniç, Murat; Sensoy, Ahmet; Akyildirim, Erdinc; Corbet, Shaen
In this article we investigate the influence that information asymmetry may have on future volatility, liquidity, market toxicity, and returns within cryptocurrency markets. We use the adverse-selection component of the effective spread as a proxy for overall information asymmetry. Using order and trade data from the Bitfinex exchange, we first document statistically significant adverse-selection costs for major cryptocurrencies. Also, our results suggest that adverse-selection costs, on average, correspond to 10% of the estimated effective spread, indicating an economically significant impact of adverse-selection risk on transaction costs in cryptocurrency markets. Finally, we document that adverse-selection costs are important predictors of intraday volatility, liquidity, market toxicity, and returns.
Citation Count: 0
Aid and Technological Cooperation as a Foreign Policy Tool for Emerging Donors: The Case of Brazil
(Uluslararasi Iliskiler Konseyi Dernegi, 2022) Akinci, Basri Alp
[Abstract Not Available]
Citation Count: 0
Algı mı, söylem mi? Kopenhag Okulu ve yeni-klasik gerçekçilikte güvenlik tehditleri
(Uluslararası İlişkiler Konseyi Derneği İktisadi İşletmesi, 2011) Akgül Açıkmeşe, Sinem
Bu makale, güvenlik tehditlerinin ortaya çıkışı bakımından yeni-klasik gerçekçilikteki algısal yaklaşımla, Kopenhag Okulunun söylemle inşaya dayalı yöntemini karşılaştırmaktadır. Makalenin hareket noktası, güvenlik tehditlerinin içeriği ve güvenlik aktörleri bakımından farklı perspektifl ere sahip bu iki yaklaşımın güvenliğin çalışılmasında metodolojik benzerlikler içermesi nedeniyle karşılaştırılabilir olduğu varsayımıdır. Makale, tehditlerin ortaya çıkışı bakımından yeni-klasik gerçekçiliğin algılara dayalı öznel yaklaşımının Kopenhag Okulu tarafından kısmen benimsendiğini vurgulayarak, Okulun söyleme dayalı özneler-arası alternatif bir model geliştirdiğini aktarmaktadır. Bu çerçevede, makale öncelikle Güvenlik Çalışmaları yazınında güvenlik tehdidinin içeriği konusundaki tartışmalara yer vermektedir. Ardından, yeni-klasik gerçekçiliği çatısında barındıran Gerçekçi Güvenlik Çalışmalarının tehdidin içeriği ve ortaya çıkışına dair varsayımlarını karşılaştırmalı olarak değerlendirmekte ve yeni-klasik gerçekçiliğin algısal perspektifi ni analiz etmektedir. Son olarak, Kopenhag Okulunun tehditlerle ilgili analizinin çerçevesini oluşturan güvenlikleştirme yaklaşımının tehditlerin kapsamı ve dayanağına dair tespitlerini Okulun kullandığı söz edimi, siyaset teorisi ve söylem analizi perspektifl erinden yeni-klasik gerçekçilikle karşılaştırmalı olarak incelemektedir.
Citation Count: 0
Amplitude and Frequency Modulations with Cellular Neural Networks
(Springer, 2015) Tander, Baran; Özmen, Atilla
Amplitude and frequency modulations are still the most popular modulation techniques in data transmission at telecommunication systems such as radio and television broadcasting gsm etc. However the architectures of these individual systems are totally different. In this paper it is shown that a cellular neural network with an opposite-sign template can behave either as an amplitude or a frequency modulator. Firstly a brief information about these networks is given and then the amplitude and frequency surfaces of the generated quasi-sine oscillations are sketched with respect to various values of their cloning templates. Secondly it is proved that any of these types of modulations can be performed by only varying the template components without ever changing their structure. Finally a circuit is designed simulations are presented and performance of the proposed system is evaluated. The main contribution of this work is to show that both amplitude and frequency modulations can be realized under the same architecture with a simple technique specifically by treating the input signals as template components.
Citation Count: 12
An Analysis of International Relations Academics in Turkey and their approaches to the field: TRIP 2014 Faculty Survey Results
(Uluslararası İlişkiler Konseyi Derneği, 2016) Aydın, Mustafa; Hisarlıoğlu, Fulya; Yazgan, Korhan
Despite the increasing interest in the studies inquiring the limits autonomous character of and the interactions between the International Relations (IR) discipline and other academic fields the scope and scale of empirical research on these issues are relatively small. In order to contribute to the discussion on the limits and peculiarities of the IR discipline and to shed light on the development current status and major characteristics of the IR studies in Turkey its place in the global IR discipline and the views of LR. scholars on major issues on the global regional and national agenda two surveys were conducted by the International Relations Council of Turkey (IRCT) in 2007 and 2009. Later on the IRTC collaborated with the Institute for the Theory and Practice of International Relations at the College of William and Mary to conduct further surveys in 2011 and 2014. This paper presents findings of the last survey on Turkey based on the worldwide research simultaneously conducted in 31 different countries in September 2014.
Citation Count: 10
An analysis of international relations academics in Turkey and their approaches to the field: TRIP 2014 faculty survey results;
(International Relations Council of Turkey, 2016) Aydın, Mustafa; Hisarlioğlu,F.; Yazgan,K.
Despite the increasing interest in the studies inquiring the limits, autonomous character of and the interactions between the International Relations (IR) discipline and other academic fields, the scope and scale of empirical research on these issues are relatively small. In order to contribute to the discussion on the limits and peculiarities of the IR discipline and to shed light on the development, current status and major characteristics of the IR studies in Turkey, its place in the global IR discipline and the views of IR scholars on major issues on the global, regional and national agenda, two surveys were conducted by the International Relations Council of Turkey (IRCT) in 2007 and 2009. Later on, the IRTC collaborated with the Institute for the Theory and Practice of International Relations at the College of William and Mary to conduct further surveys in 2011 and 2014. This paper presents findings of the last survey on Turkey, based on the worldwide research simultaneously conducted in 31 different countries in September 2014. © 2016, International Relations Council of Turkey. All rights reserved.
Citation Count: 0
Analyzing multiple pricing decisions for substitutes under stochastic demand: An experiment
(John Wiley & Sons Ltd, 2022) Ayvaz-Cavdaroglu, Nur; Buyukboyaci, Muruvvet
This study investigates how individuals choose prices for two substitutes under stochastic demand in an airline setting. We design two treatments: symmetrical and asymmetrical, meaning the demand distribution of the two flights having the same size of support or not. Several insights are obtained. First, the decision makers' price choices are closer to the theoretical benchmarks in the symmetrical setting. Next, the subjects do not want to overprice and fly with empty seats, exhibiting loss aversion with reference point. Finally, the subjects often treat the flights as independent rather than interrelated and price them separately, using an anchoring-and-adjusting heuristic.
Antibiyotikli kemik çimentosunun 0 ve 15. günlerde mekanik dayanımı: Surgical Simplex P kemik çimentosu ve teikoplanin ile biyomekanik çalışma
(Türk Ortopedi ve Travmatoloji Derneği, 2002) Göğüş, Abdullah; Akman, Şenol; Göksan, Bora S.; Bozdağ, Ergün
Amaç: Mekanik dayanım açısından 40 gr belirli bir kemik çimentosuna katılabilecek belirli bir antibiyotiğin maksimum dozu "0. gün" ve antibiyotik salınımı sonrası "15. gün" için araştırıldı. Çalışma planı: 40 g Surgical Simplex P kemik çimentosuna 0, 400, 800,1200,1600, 2000, 3200 ve 4000 mg teikoplanin katılarak sekiz deney grubu oluşturuldu. Kompresyon ve dört nokta eğme mekanik dayanım testleri için üçüncü kuşak sement hazırlama ve uygulama koşullarında örnekler elde edildi. Her bir konsantrasyon için "0. gün" ve "15. gün" için 10'ar örnek oluşturuldu. Örneklerin mekanik dayanım testleri ASTM ve ISO standartlarına göre "0. gün" ve 37∘ C su banyosunda antibiyotik salınımı sonrası "15. gün"de yapıldı. Değişik antibiyotik konsantrasyonları 0 mg kontrol grubu ile, ayrıca aynı antibiyotik konsantrasyonlarının 0. gün ve 15. gün mekanik test sonuçları karşılaştırıldı. Sonuçlar: Kompresyon testlerinde "0. gün" grubu içinde anlamlı farklılık bulunmadı; "15. gün" grubunda ise 800 mg'den itibaren anlamlı dayanım azalması saptandı. Her iki grupta tüm konsantrasyonlarda elde edilen mekanik dayanım değerleri ASTM alt limiti olan 70 MPa'nın üzerindeydi. Dört nokta eğme testinde "0. gün" grubunda 1200 mg'den itibaren, "15. gün" grubunda ise 400 mg'den itibaren anlamlı dayanım azalması saptandı. "15. gün" grubundan 4000 mg ISO'nun alt limiti olan 50 MPa'nın altında kalırken, 3200 ve 2000 mg gruplarında 50 MPa'ya çok yakın sonuçlar elde edildi. Çıkarımlar: Deney sonuçları, üçüncü kuşak çimento hazırlama ve uygulama koşullarında, 40 gr Surgical Simplex P kemik çimentosuna güvenle katılabilecek en yüksek teikoplanin dozunun 1600 mg olduğunu gösterdi.
Citation Count: 14
Antioxidant and Enzyme Inhibitory Properties, and HPLC-MS/MS Profiles of Different Extracts of Arabis carduchorum Boiss.: An Endemic Plant to Turkey
(Mdpi, 2022) Uba, Abdullahi Ibrahim; Zengin, Gokhan; Montesano, Domenico; Cakilcioglu, Ugur; Selvi, Selami; Ulusan, Musa Denizhan; Caprioli, Giovanni
In this study, six extracts of Arabis carduchorum prepared from solvents of varying polarity (water, methanol, ethyl acetate, dichloromethane, and n-hexane) were investigated for their chemical profiles and total phenolic and flavonoid contents (TPC/TFC) using HPLC-MS/MS and spectrophotometric/colorimetric assays, respectively, along with the assessment of their antioxidant and enzyme inhibitory effects. In general, the polar extracts (methanol, water, and infusion) showed higher TPC/TFC than the other extracts (range: 13.73-26.62 mg GAE/g; 2.66-52.95 mg RE/g, respectively). The total antioxidant capacity of the polar extracts ranged from 0.90-1.85 mmol TE/g in phosphomolybdenum assay, while the free radical scavenging potential ranged from 4.36-32.13 mg TE/g and 12.58-67.73 mg TE/g in DPPH and ABTS assays, respectively. While the water and infuse extract inhibited only butyrylcholinesterase (2.68 and 2.39 mg GALAE/g, respectively), the other extracts were found to inhibit both acetyl- and butyryl-cholinesterases (0.96-2.73 mg GALAE/g and 1.86-5.11 mg GALAE/g, respectively). On the contrary, all extracts exhibited anti-tyrosinase (40.24-59.22 mg KAE/g) and anti-amylase (0.09-0.63 mmol ACAE/g) activities. Overall, this study highlighted the effect of solvent polarity on the extraction of bioactive compounds and the biological properties of the extracts of A. carduchorum; hence, the results obtained could be used to guide optimum extraction in future studies.

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