Effect of MoS<sub>2</sub> on Simple and Novel PEG/κ-Carrageenan Hydrogels for TNBC Cancer Drug Delivery

dc.authorscopusid58986629200
dc.authorscopusid55207663200
dc.contributor.authorHassan, Gana
dc.contributor.authorUysal, Bengu Ozugur
dc.date.accessioned2024-06-23T21:37:40Z
dc.date.available2024-06-23T21:37:40Z
dc.date.issued2024
dc.departmentKadir Has Universityen_US
dc.department-temp[Hassan, Gana] Kadir Has Univ, Sch Grad Studies, Mat Sci & Nanotechnol, Istanbul, Turkiye; Kadir Has Univ, Fac Engn & Nat Sci, Istanbul, Turkiye; [Uysal, Bengu Ozugur] Kadir Has Univ, Fac Engn & Nat Sci, TR-34083 Istanbul, Turkiyeen_US
dc.description.abstractMolybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used in biomedical research. Especially, MoS2-nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties. MoS2 can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area, improving its tumor targeting and colloidal stability, as well as accuracy and sensitivity for detecting specific biomarkers. At the same time, in the near-infrared (NIR) window, MoS2 has excellent optical absorption and prominent photothermal conversion efficiency, which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release. Significantly, the modified MoS2-nanocomposite can specifically respond to the tumor microenvironment, leading to drug accumulation in the tumor site increased, reducing its side effects on non-cancerous tissues, and improved therapeutic effect. In this review, we introduced the latest developments of MoS2-nanocomposites in cancer diagnosis and therapy, mainly focusing on biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, and combination therapy. Furthermore, we also discuss the current challenges and prospects of MoS2-nanocomposites in cancer treatment.en_US
dc.identifier.citation0
dc.identifier.doi10.1080/00222348.2024.2338631
dc.identifier.issn0022-2348
dc.identifier.issn1525-609X
dc.identifier.scopus2-s2.0-85190445171
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/00222348.2024.2338631
dc.identifier.urihttps://hdl.handle.net/20.500.12469/5736
dc.identifier.wosWOS:001199394300001
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherTaylor & Francis incen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmolybdenum disulfideen_US
dc.subjectgelationen_US
dc.subjectswellingen_US
dc.subjectkappa-carrageenanen_US
dc.subjectpolyethylene glycolen_US
dc.titleEffect of MoS<sub>2</sub> on Simple and Novel PEG/κ-Carrageenan Hydrogels for TNBC Cancer Drug Deliveryen_US
dc.typeArticleen_US
dspace.entity.typePublication

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