WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://gcris.khas.edu.tr/handle/20.500.12469/4465

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Citation Count: 30
Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation
(Arnold Hodder Headline Plc., 1999) Yılmaz, Mert; Ener, Serdar; Akalın, Halis; Sağdıç, Kadir; Serdar, O. Akin; Cengiz, Mete
The systemic inflammatory response to cardiopulmonary bypass (CPB) is associated with increased production of cytokines. This systemic inflammatory response characterized by the activation of interleukin-6 (IL-6) and interleukin-8 (IL-8) during and after CPB is well documented. A prospective randomized double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (MPSS) on the circulating levels of serum cytokines and clinical outcome. Twenty patients were randomly divided into two groups on the basis of the administration of low-dose(1 mg/kg) MPSS in = 10) and placebo in = 10) into the pump prime solution. All patients were scheduled to undergo a primary
Citation Count: 0
A synthesis tool for the multiplierless realization of FIR-based multirate DSP systems
(IEEE, 2000) Yurdakul, Arda
In this study a synthesis tool using a novel multirate folding technique which handles each FIR filter in a multirate DSP system as a single node is developed. A new architecture is presented for the multiplierless realization of a fold of multirate FIR filters. This synthesizer fully exploits the redundancies (i.e. `idle' and `missing' cycles) and common terms in multirate systems without sacrificing from overall system quality to produce multiplierless multirate systems. It also enables the usage of a single clock for all parts of the circuit.
Citation Count: 0
Does different orientation of the Medtronic Hall tilting disc valve in the aortic position effect transvalvuler pressure gradients?
(Medimond Srl, 2000) Güden, Metin; Akpınar, Belhhan; Sağbaş, Ertan; Sanisoğlu, İlhan; Arpaz, M.; Bayındır, Osman
The effect of valve orientation during aortic valve replacement (AVR) with the Medtronic Hall (MH) tilting disc valve on transvalvuler pressure gradients was evaluated. 30 patients (pts) undergoing isolated AVR received a MH which was oriented so that the greater opening of the valve faced the non coronary aortic sinus. There were 12 male and 8 female pts in this group with a mean age of 59 +/- 5.2 years. An echocardiographic examination was performed 6 days after the operation and resting transvalvuler gradients were measured (Group 1). The gradients were compared with the results of 30 pts. who had undergone AVR with the same valve previously but with the orientation of the greater opening towards the left or the right coronary sinus (Group 2). In Group 1 the mean valve size was 22 mm. and the measured mean valvuler gradient was 24/13 mmHg (peak/mean). In Group 2 the mean valve size was 22.1 mm. and the measured mean valvuler gradient was 31/20 mmHg (peak/mean). Student's t test was used for statistical analysis and transvalvular gradients in Group 1 were found to be significantly lower than Group 2 (p>005). Implantation with greater opening of the tilting mechanical valve facing the non-coronary sinus seems to result in lower transvalvuler gradients than other orientations.
Citation Count: 5
Presence and localization of connexins 43 and 26 in cell cultures derived from myometrial tissues from nonpregnant and pregnant women and from leiomyomas
(Mosby-Elsevier, 2000) Ciray, Haydar Nadir; Fu, Xin; Olovsson, Matts; Ahlsen, Goran; Shuman, Cheryl; Lindblom, Bo; Ulmsten, Ulf
OBJECTIVE: Our objective was to study the appearance and distribution of connexins 43 and 26 in various human myometrial cell cultures. STUDY DESIGN: Scrape loading Western blotting and immunohistochemical techniques were applied to cultured cells derived from myometrial tissues obtained from nonpregnant and pregnant women (upper and tower uterine segments) and from leiomyomas (tumor and analogous myometrial tissues). RESULTS: Scrape loading revealed the presence or metabolic coupling in all tissues. indirect immunohistochemical studies showed membrane localization of connexin 43 in all myometrial cultures. Western blots and indirect immunohistochemical studies showed the presence and localization of the connexin 26 protein and associated gap junctions in tissues from myomas and from nonpregnant and pregnant women except for those derived from the upper segment of the pregnant uterus. CONCLUSION: These results show that human myometrial cultures express various gap junction proteins and that there are regional differences in expression of connexins in tissues from pregnant women.
Citation Count: 20
In situ split costal cartilage graft harvesting through a small incision using a gouge
(Lippincott Williams & Wilkins, 2000) Ağaoğlu, Galip; Erol, O. Onur
A costal cartilage graft is one of the most useful materials in reconstructive plastic surgery. In this article a technique of in situ split costal cartilage graft harvesting through a small incision (2 to 3 cm) using a gouge is described. The technique used has many advantages: it is a simple technique is easy to learn and can be performed quickly through a small incision. By avoiding complete costal cartilage graft harvesting the associated potential complications such as pleural perforation chest wall deformities long-lasting postoperative pain and incisional scar length are reduced. This technique will be useful in selected cases for which a complete block of costal cartilage graft is not needed.
Citation Count: 17
Off-pump coronary artery bypass grafting with use of the octopus 2 stabilization system
(2000) Akpınar, Belhhan; Güden, Mustafa; Sağbaş, Ertan; Sanisoğlu, İlhan; Aytekin, Vedat; Bayındır, Osman
Background: The treatment of coronary artery disease has evolved rapidly over the last two decades. The gold standard of surgical revascularization, the on-pump coronary artery bypass graft, has been challenged by the development of percutaneous transluminal coronary angioplasty. Our experience with the alternative of the off-pump ("beating heart") coronary artery bypass (OPCAB) technique during a period of 18 months suggests that OPCAB avoids the complications of cardiopulmonary bypass and offers patients the benefit of long-term graft patency that greatly exceeds that of current endovascular technologies. Methods: The early results of 126 OPCAB procedures performed through a medial sternotomy incision during a period of 18 months were evaluated. There were 80 male and 46 female patients, with a mean age of 69 +/- 4.3 years. Emergency cases and reoperations were not included. A total of 268 anastomoses were performed, with a mean number of 2.12 anastomoses per patient. Conduits used, with their percentage of use, were: left internal thoracic artery (LITA) (100%), right internal thoracic artery (11.1%), greater saphenous vein (84%), and radial artery (31%). In 72% of the cases, off-pump surgery was chosen because of patient risk factors such as atherosclerotic aortic disease, previous cerebrovascular accident or carotid artery disease, renal dysfunction, malignancy or poor left ventricular function. Results: There was no operative mortality. One-month postoperative mortality was three patients (2.3%). Two died because of mesenteric ischemia, and the other death was due to cardiac failure. Seventy-one patients had a control angiogram before discharge. The patency of LITA anastomosis was 100% while overall patency rate was 95%. In 43 patients for whom an angiogram could not be performed, a Thallum 201 stress test was performed three months postoperatively. Thirty-eight patients had a normal test while five patients showed signs of ischemia. These patients had a control angiogram: in four patients anastomoses were patent, but in one patient there was a severe narrowing of a venous anastomosis to the distal right coronary artery (RCA) which was corrected with angioplasty. In the whole series eight patients (6.3%) refused to have any control examination. Conclusions: Our early results suggest that off-pump CABG with Octopus 2 (Medtronic, Inc., Minneapolis, MN) can be a good alternative in high risk patients who need multiple vessel revascularization.
Citation Count: 4
Association of lipoprotein(a) concentration and apo(a) isoform size with restenosis after percutaneous transluminal coronary angioplasty
(Springer Verlag, 2000) Sırıkcı, Onder; Aytekin, Vedat; Demiroglu, I. C. C.; Demiroğlu, Cemşid; Marcovina, S.M.
Lp(a) is a unique class of lipoprotein particles that exhibits a considerable size heterogeneity resulting from the size polymorphism of apo(a) its unique protein component. An elevated level of Lp(a) in plasma has been proposed to be a risk factor for premature development of coronary artery disease. To evaluate the relationship between Lp(a) concentration and apo(a) isoform size with restenosis after percutaneous transluminal coronary angioplasty Lp(a) levels and apo(a) phenotypes were determined in 204 patients who underwent a successful coronary angioplasty procedure and stent implantation. The patients were followed with clinical examinations and exercise tests at 1 3 and 6 months and a control coronary angiography was performed after 6 months to evaluate restenosis. Lp(a) levels were determined with an ELISA that is insensitive to the size heterogeneity of Lp(a) and the apo(a) isoforms were determined by a high-resolution agarose gel electrophoresis method followed by immunoblotting with a specific monoclonal antibody. Of the 146 patients who underwent angiographic evaluation 57 (39%) had restenosis whereas 89 (61%) did not. Lp(a) levels and the distribution of the expressed apo(a) phenotypes were compared in these two groups of patients. Although the mean and median Lp(a) levels were higher in the restenosed group the difference was not statistically significant. However a significant difference in Lp(a) values was found in women (P=0.043) even though because of the small number of women in the study (n=35) no sound conclusions can be reached on the predictive role of Lp(a) in restenosis. There also was no difference in the distribution of apo(a) phenotypes between the two groups. Because of their wide distribution Lp(a) values and apo(a) isoforms do not seem to be a useful indicator of risk of restenosis after percutaneous transluminal coronary angioplasty in our study cohort.
Citation Count: 0
Intraoperative thermal coronary angiography: quality control
(Medimond Srl, 2000) Sönmez, Barış; Tansal, Selim; Yagan, N.; Ünal, M.; Arbatlı, Harun; Korkut, K.; Demirsoy, Ergun; Bayındır, Osman
Per operative coronary angiography has always been desired by coronary surgeons. Direct coronary angiographic imaging is not practical since needs contrast injection requires radiation and excessive technology with experienced staff which adds more expenses. Thermal angiography device IVA-2000 (OPGAL) is started to be used in our coronary bypass operations as a routine procedure. Thermal imaging provides an effective and real time coronary angiograms which provides very clear coronary angiograms as well as graft flows. The temperature differences generated in between the myocardium and the coronary arteries by injecting cold cardioplegic solution into the proximal end of the vein graft or by warm blood running through an internal thoracic artery graft creates an angiographic image and provides graft flow with termodilution technique after cross clamp released. Thermal images provided with thermal camera easy to tax no need for extra staff no side effects of contrast media to the patients and no radiation effect to the theatre stuff also. We will demonstrate basic principal of thermal camera and thermal coronary angiograms of different patients with different aspects.
Citation Count: 0
Use of octopus 2 stabilization system for off-pump coronary artery bypass grafting
(Medimond S R L, 2000) Güden, M; Akpmar, B; Sagbas, E; Sanisoglu, I; Aytekin, V; Bayindir, O
The early results of 126 off pump CABG procedures performed through a median sternotomy incision (OPCAB) during a period of 18 months were evaluated. The mean age was 69+/-4.3 years. There were 80 male and 46 female patients. Emergency cases and reoperations were not included. A total of 268 anatomosis were performed with a mean number of 2.12 anastomosis Per patient. Conduits used were: LITA (100%), RITA (11.1%) GSV in (84%) and radial artery in (31%) of cases. In 72% of the cases, off pump surgery was chosen because of patient risk factors such as atherosclerotic aortic disease, previous CVA or carotid artery disease, renal dysfunction, malignancy and poor LV function. There was no operative mortality. One month mortality was 3 patients (2.3%). Two died because of mesentheric ischemia. 71 patients had a control angiogram before discharge. The patency of LITA anastomosis was 100% while overall patency rate was 95%. In 43 patients were an angiogram could not be performed, a Thalium 201 stress test was performed 3 months postoperatively. 38 had a normal test while 5 patients showed signs of ischemia. These patients had a control angiogram, in four patients anastomosis were patent, but in one patient tere was a severe narrowing of a venous anastomosis to the distal right coronary which was corrected with angioplasty. In the whole series 8 patients refused to have any control examination (6.3%). Our early results suggest that off pump CABG with Octopus stabilisation can be a good alternative in high risk patients who need multiple vessel revascularisation.
Citation Count: 21
Going against the national cultural grain: a longitudinal case study of organizational culture change in Turkish higher education
(Carfax Publishing, 2000) Herguner, Gülten; Reeves, Nigel B.R.
This paper presents results of a longitudinal case study inquiry into the measurement of organizational culture change through the implementation of total quality management (TQM) concepts in a higher education context. The inquiry deals with the relationship between national culture and the company corporate culture the consequences of manager style change for TQM implementation and how culture change can be measured adequately. The results are achieved by the utilization of external (quantitative) and internal (qualitative) measurement devices. Limitations consequent upon the number of participants and the dual role of the researcher indicate the potential value of further investigations into the topic using these devices. The main conclusion is that the maintenance of TQM systems without continued senior managerial commitment may not suffice to secure change and prevent a reversion to earlier cultural patterns. Certainly since the findings of this inquiry are limited to one case study it would be unwise to assume that similar results would necessarily pertain in other higher education contexts. Nevertheless we are of the view that the findings are suggestive of the pressures imposed on organizational change by national cultural patterns. The devices implemented for measuring organizational cultural change while not designed for that purpose have however yielded sufficiently well-defined results to suggest the value of similar implementations to gain insight into the topic in further higher education and other organizational contexts.
Citation Count: 23
The use of the 5-HT3-receptor antagonist ondansetron for the treatment of postcardiotomy delirium
(W.B. Saunders Co Ltd, 2000) Bayındır, Osman; Akpınar, Belhhan; Can, Erol; Güden, Mustafa; Sönmez, Bingür; Demiroğlu, Cemşid
Objective:To evaluate the effect of the 5-HT3-receptor antagonist ondansetron in patients with postcardiotomy delirium. Design: Prospective study. Setting: University hospital. Participants: Thirty-five patients who had undergone coronary artery bypass graft surgery. Interventions: Thirty-five patients 23 men and 12 women who developed delirium in the intensive care unit after coronary artery bypass graft surgery were included. Mean patient age was 51.3 years (range 36 to 79 years). A mental status scoring scale was developed and patients were scored 0 to 4 according to their delirium status after confirming that there were no correctable metabolic abnormalities as an underlying cause for delirium. Normal behavior was scored as 0 and severe verbal and physical agitation was scored as 4. Patients received a single dose of ondansetron 8 mg intravenously and were reevaluated 10 minutes later. Measurements and Main Results: Before the treatment 7 patients had a score of 2 (20)
Citation Count: 33
Primary epiploic appendagitis CT manifestations
(Elsevier Science Inc, 2000) Şırvancı, Mustafa; Tekelioğlu, Mehmet H.; Duran, Cihan; Yardımcı, Hakan; Onat, Levent; Özer, Kadir
Inflammation of an epiploic appendage is considered to be a rare cause of acute abdomen. Recently it has been reported that typical computed tomography (CT) findings of primary epiploic appendagitis (PEA) provide a definitive diagnosis in most of the cases. However since these papers are only few they are easily overlooked by the practicing radiologists. Our purpose is to add four new cases to the existing literature and to perform a review of the literature. (C) 2001 Elsevier Science Inc. All rights reserved.
Citation Count: 24
New modification in otoplasty: Anterior approach
(Lippincott Williams & Wilkins, 2001) Erol, O. Onur
After harvesting the conchal cartilage in a large series of secondary rhinoplasties using the anterior approach there was a marked improvement in the shape of the auricle with unnoticeable scarring hidden under the convolution of the antihelix. In this series of 250 cases there were no hypertrophic scars or keloid formations. Based on these favorable results a new modification of otoplasty was developed using only the anterior approach. Between 1992 and 2000 108 otoplasties were performed on 55 patients to correct the prominent ear using only the anterior approach. All maneuvers used in modern otoplasty such as conchal reduction scaphal cartilage scoring and folding placement of horizontal mattress buried sutures conchal setback and the positioning of the tail and upper pole can be easily and effectively performed using only the anterior approach as described in this article. The use of an anterior approach does not disturb the neurovascular system of the ear because it is located on the ear's posterior side. Overall patient and physician satisfaction has continued to be very high during the 8 years that this technique has been used. Some patients experienced a few minor complications such as postoperative pain (16.3 percent) late suture reaction (1.8 percent) hidden helix (3.6 percent) and partial relapse (3.6 percent) that were easily corrected by the application of a Kaye-type buried suture and that were not directly related to the technique.
Citation Count: 0
The stability constants of the rare earth complexes with trimetaphosphoric acid
(Soc Chimica Italiana, 2001) Şungur, Şana Kutun
The stability constants of the complexes formed between the rare earth metal ions and the anion of trimetaphosphoric acid have been determined at a temperature of 20 degreesC and an ionic strength of mu =0.1 by the ion-exchange equilibrium method. The investigations indicate that stabilities of complexes increased from La to Lu.The highest and the lowest stability constant values (beta) were found to be 7.76 and 3.82 for Lu3+ and La3+ respectively.
Citation Count: 12
Acute aortic valve regurgitation secondary to blunt chest trauma
(Texas Heart Inst., 2001) Ünal, Mehmet; Demirsoy, Ergun; Göğüş, Abdullah; Arbatlı, Harun; Hamzaoğlu, Azmi; Sönmez, Bingür
Blunt injury to the cardiac valves leads to progressive acute ventricular failure which often requires urgent surgical management In this case report we describe an acute aortic valve rupture caused by air-bag inflation during an automobile accident. Laceration of an aortic valve cusp was treated successfully with urgent aortic valve replacement. A concomitant orthopedic injury was treated electively 15 days after cardiac surgery. Acute aortic valve rupture is a very rare complication of blunt chest trauma. We discuss how to diagnose and manage this potentially catastrophic event.
Citation Count: 4
The use of composite stentless valves with graft extension for the treatment of ascending aortic aneurysms
(Elsevier Science Bv, 2001) Akpınar, Belhhan; Güden, Mustafa
[Abstract Not Available]
Citation Count: 1
Long-standing seroma after ultrasound-assisted liposuction
(Lippincott Williams & Wilkins, 2001) Ağaoğlu, Galip; Erol, O. Onur
[Abstract Not Available]
Citation Count: 1
One-stage surgical correction of congenital thoracic lordosis - report of 2 cases
(Taylor & Francis, 2001) Göğüş, Abdullah; Talu, Ufuk; Hamzaoğlu, Azmi
[Abstract Not Available]
Citation Count: 7
Reconstruction of the superior labial sulcus in secondary bilateral cleft lip deformities: An inverted U-shaped flap
(Lippincott Williams & Wilkins, 2001) Erol, O. Onur; Ağaoğlu, Galip
A shallow buccal sulcus deformity following bilateral cleft lip repair is not rare. A variety of techniques are described for the secondary reconstruction of a deficient sulcus. Most of these are associated with a variable amount of contraction with subsequent obliteration of the sulcus. In this article an inverted U-shaped flap is described for the secondary reconstruction of the deficient sublabial sulcus. In these patients mobility of the upper lip was severely restricted so orthodontic treatment was not possible. This technique was used in nine patients whose primary cleft lip repairs were performed in different institutions. The amount of re-adhesion or contraction was negligible because a bare surface was not left behind and skin or mucosal grafts were not used. By advancing the lateral segments of the lip medially projection of the upper lip was increased. The procedure resulted in adequate upper lip mobility for all patients and sufficient sulcus was maintained during 1 to 6 years of follow-up. The patients experienced no difficulty with orthodontic appliances after this reconstruction.
Citation Count: 9
Anterior instrumentation for adolescent idiopathic scoliosis
(Springer Verlag, 2001) Göğüş, Abdullah; Talu, Ufuk; Akman, Sümeyra; Sar, Can; Hamzaoğlu, Azmi; Eralp, Levent
Thirty-two patients with adolescent idiopathic scoliosis underwent anterior fusion with rigid single rod (third generation instrumentation) and titanium mesh cages. The mean follow-up was 31 (24-45) months and the mean age was 14.9 years. There were 8 patients with King type I 10 with type II 6 with type III 4 with type IV and 4 with lumbar curves. Titanium mesh cages were used in all the lumbar procedures and at the cranial and caudal ends of the instrumented area in thoracic cases. All the patients were immobilized in an orthosis for 3-6 months postoperatively. Mean preoperative primary coronal Cobb angle of 56 degrees was improved to 8.6 degrees. Average correction rate was 84%. Sagittal balance was restored with a mean thoracic kyphosis of 28 degrees and a mean lumbar lordosis of 38 degrees. Spontaneous secondary curve decompensation did not occur and postoperative thoracolumbar junctional kyphosis was not seen. One case had to be revised due to proximal screw pull out and loss of correction.

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