PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://gcris.khas.edu.tr/handle/20.500.12469/4466

Browse

Now showing 1 - 20 of 67

Citation Count: 4
Addressing climate change with behavioral science: A global intervention tournament in 63 countries
(Amer Assoc Advancement Science, 2024) Vlasceanu, Madalina; Doell, Kimberly C.; Bak-Coleman, Joseph B.; Todorova, Boryana; Berkebile-Weinberg, Michael M.; Grayson, Samantha J.; Van Bavel, Jay J.
Effectively reducing climate change requires marked, global behavior change. However, it is unclear which strategies are most likely to motivate people to change their climate beliefs and behaviors. Here, we tested 11 expert-crowdsourced interventions on four climate mitigation outcomes: beliefs, policy support, information sharing intention, and an effortful tree-planting behavioral task. Across 59,440 participants from 63 countries, the interventions' effectiveness was small, largely limited to nonclimate skeptics, and differed across outcomes: Beliefs were strengthened mostly by decreasing psychological distance (by 2.3%), policy support by writing a letter to a future-generation member (2.6%), information sharing by negative emotion induction (12.1%), and no intervention increased the more effortful behavior-several interventions even reduced tree planting. Last, the effects of each intervention differed depending on people's initial climate beliefs. These findings suggest that the impact of behavioral climate interventions varies across audiences and target behaviors.
Citation Count: 0
The association of HLA-DRB1 alleles and MBL2 gene variant in pediatric acute lymphoblastic leukemia patients
(Elsevier, 2024) Oguz, Rustu; Ciftci, Hayriye Senturk; Gokce, Muge; Ogret, Yeliz; Karadeniz, Sedat; Pehlivan, Sacide; Ayd, Filiz
Introduction: Epidemio logic studies on pediatric acute lymphoblastic leukemias (ALL) have been conducted to evaluate the possible risk factors including genetic, infectious and environmental factors with the objective of idenfying the etiology. Mannose-binding lectin 2 (MBL2) plays an important role in first-line immune defense. HLA DRB1 alleles play a role in presentation of peptides to T cells and in activation of the adaptive immune response. Objective: In our study, we aimed to investigate both the MBL2 gene variant and HLA-DRB1 alleles in pediatric ALL patients. Materials: In this study, 86 high-risk ALL patients and 100 controls were included. Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (PCR-RFLP) and PCRsequence specific primer (SSP) methods were used for detection of polymorphism of the MBL2 and HLA-DRB1 alleles, respectively. Results: The frequency of the MBL2 AB genotype was lower in female ALL patients, compared to male ALL patients (p = 0.034). An association was found between the MBL2 BB genotype and DRB1*07 and among patients with the MBL2 BB genotype; those who also carried the DRB1*07 and *04 alleles were significantly higher than those without the DRB1*07 and *04 alleles. (p = 0.048, p = 0.022, respectively). Conclusion: This is the first study suggesting that the MBL2 BB genotype in association with the DRB1*07 or co-inheritance of the HLA-DRB1*04 and HLA DRB1*07 may have an impact on the etiopathogenesis of the disease. (c) 2023 Associa & ccedil;& atilde;o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Citation Count: 0
Background TV and infant-family interactions: Insights from home observations
(Wiley, 2024) Uzundag, Berna A.; Koskulu-Sancar, Suemeyye; Kuntay, Aylin C.
Background television has been found to negatively impact children's language development and self-regulatory skills, possibly due to decreased parent-child interactions. Most of the research on the relationship between background TV and caregiver-child interactions has been conducted in laboratory settings. In the current study, we conducted home observations and investigated whether infants engage in fewer interactions with family members in homes where background TV is more prevalent. We observed 32 infants at the ages of 8, 10, and 18 months in their home environments, coding for dyadic interactions (e.g., parent talking to and/or engaging with the child), triadic interactions (e.g., parent and infant play with a toy together), and infants' individual activities. Our findings revealed that background TV was negatively associated with the time infants spent in triadic interactions, positively associated with time spent engaging in individual activities, and not significantly related to the time spent in dyadic interactions. Apart from the relationship between background TV and individual activity time at 8 months, these associations remained significant even after accounting for families' socioeconomic status. These findings imply a correlation between background TV exposure and caregiver-infant-object interactions, warranting a longitudinal analysis with larger sample sizes.
Citation Count: 4
Beyond sightseeing: How can tourism affect public/global health in modern society?
(University of Edinburgh, 2022) Kozak, Metin; Kozak,M.; Jiang,Y.
[No abstract available]
Citation Count: 0
Children's questions and teachers' responses about COVID-19 in Türkiye and the US
(Public Library Science, 2024) Unlutabak, Burcu; Trujillo Hernandez, Graciela; Velioglu, Ilayda; Menendez, David; Rosengren, Karl S.
Question-asking is a crucial tool for acquiring information about unseen entities, such as viruses; thus, examining children's questions within the context of COVID-19 is particularly important for understanding children's learning about the coronavirus. The study examined 3-12-year-old children's questions and teachers' responses about the COVID-19 pandemic in T & uuml;rkiye, a non-Western developing context, and the United States, a Western cultural context. A total of 119 teachers from T & uuml;rkiye and 95 teachers from the US participated in the study. Teachers completed an online survey consisting of a demographic form and a questionnaire asking them to report three questions about COVID-19 asked by children in their classrooms and their responses to these questions. We analyzed children's questions and teachers' responses for their type and content and examined demographic factors associated with children's questions and teachers' responses. Consistent with the literature, children from T & uuml;rkiye asked fewer explanation-seeking (i.e., why/how) questions than children from the United States. Children asked questions about viruses and precautions. Teachers responded to children's questions realistically in both countries. The findings have important implications for how children gain knowledge from teachers when discussing health, disease, and virus topics in two countries.
Citation Count: 10
Comparison of intraoperative transit-time flow measurement with early postoperative magnetic resonance flow mapping: In off-pump coronary artery surgery
(2003) Sanisoglu,I.; Guden,M.; Balci,C.; Sagbas,E.; Duran,C.; Akpinar,B.
The purpose of this prospective study was to evaluate graft patency of off-pump coronary artery surgery intraoperatively by transit-time flow measurement and to compare this technique with postoperative magnetic resonance flow mapping. Twenty patients (13 men and 7 women; mean age, 67.9 ± 7.6 yr) underwent off-pump coronary artery surgery. Intraoperative transit-time flow measurement of grafts was performed measuring maximum, minimum, and mean flows. For each graft, the pulsatile index was calculated by dividing the difference between the maximum and the minimum flow by the mean flow. In the early postoperative period (1st week), magnetic resonance flow mapping was performed using phase contrast flow quantification. Mean intraoperative flow values and mean magnetic resonance flow mapping values were compared. At the same postoperative session, contrast-enhanced magnetic resonance angiography was performed to evaluate graft patency. In 20 patients, a total of 49 coronary graft flows were assessed with intraoperative transit-time flow measurement and postoperative magnetic resonance flow mapping. Upon comparison, there was a strong correlation between techniques, with stable and statistically significant differences between the intraoperative and postoperative flow mapping values. One saphenous vein graft was revised intraoperatively, due to graft failure. Our data suggest that the combined use of intraoperative transit-time flow measurement and postoperative magnetic resonance flow analysis has a potential role in the assessment of graft patency in off-pump coronary artery surgery, although more study is required.
Composite Hydrogel of Polyacrylamide/Starch as a Novel Amoxicillin Delivery System
(Mdpi, 2024) Poyraz, Yagmur; Baltaci, Nisa; Hassan, Gana; Alayoubi, Oubadah; Uysal, Bengu Ozugur; Pekcan, Onder
This study investigates the development and characterization of a novel composite hydrogel composed of polyacrylamide (PAAm), starch, and gelatin for use as an amoxicillin delivery system. The optical properties, swelling behavior, and drug release profile of the composite hydrogel's were studied to evaluate its efficacy and potential applications. UV-visible spectroscopy was employed to determine the optical properties, revealing significant transparency in the visible range, which is essential for biomedical applications. The incorporation of starch and gelatin into the polyacrylamide matrix significantly enhanced the hydrogel's swelling capacity and biocompatibility. Studies on drug delivery demonstrated a sustained release profile of amoxicillin in simulated gastrointestinal fluids, which is essential for maintaining therapeutic levels for a prolonged amount of time. The results indicate that the composite hydrogel of PAAm/starch/gelatin has good swelling behavior, appealing optical characteristics, and a promising controlled drug release mechanism. These results point to this hydrogel's considerable potential as a drug delivery method, providing a viable path toward enhancing the medicinal effectiveness of amoxicillin and maybe other medications.
Citation Count: 17
Corneal ring segments (INTACS) for the treatment of asymmetrical astigmatism of the keratoconus. Follow-up after 2 years;
(2003) Tunc,Z.; Deveci,N.; Sener,B.; Bahcecioglu,H.
Objective: To evaluate the use of corneal ring segments (INTACS) for the treatment of asymmetrical astigmatism in keratoconus. Material and methods: This prospective study involved nine eyes of seven patients who were operated on between December 1998 and June 2000. A case of keratoconus with opacified cornea was excluded from this study. The patients chosen were contact lens-intolerant. The surgical intervention was carried out under topical anesthesia. The INTACS (Addition Technology) corneal ring insert was inserted approximately 68% of the peripheral corneal depth and was centered to the cone of the cornea. Results: No intraoperative complications occurred. We noted a flattening of the central cornea and a decrease in irregular astigmatism for all patients. Mean preoperative uncorrected visual acuity was less than 1/10. Postoperatively two eyes had an uncorrected visual acuity of 10/10, seven eyes showed an improvement from an uncorrected visual acuity of 2/10 to 7/10. Conclusion: We have observed that the flattening effect of INTACS inserts on the soft corneal keratoconic tissue and on the high astigmatic tissue seems greater than that produced in normal cornea. Implantation of INTACS resulted in a significant reduction in asymmetrical astigmatism of the keratoconus.
Citation Count: 0
Do autistic adults spontaneously reason about belief? A detailed exploration of alternative explanations
(Royal Soc, 2024) Wu, Ruihan; Lim, Jing Tian; Ahmed, Zahra; Berger, Rachael; Acem, Ensar; Chowdhury, Ishita; White, Sarah J.
Southgate et al.'s (Southgate 2007 Psychol. Sci. 18, 587-92 (doi:10.1111/j.1467-9280.2007.01944.x)) anticipatory-looking paradigm has presented exciting yet inconclusive evidence surrounding spontaneous mentalizing in autism. The present study aimed to develop this paradigm to address alternative explanations for the lack of predictive eye movements on false-belief tasks by autistic adults. This was achieved through implementing a multi-trial design with matched true-belief conditions, and both high and low inhibitory demand false-belief conditions. We also sought to inspect if any group differences were related to group-specific patterns of attention on key events. Autistic adults were compared with non-autistic adults on this adapted implicit mentalizing task and an established explicit task. The two groups performed equally well in the explicit task; however, autistic adults did not show anticipatory-looking behaviour in the false-belief trials of the implicit task. Critically, both groups showed the same attentional distribution in the implicit task prior to action prediction, indicating that autistic adults process information from social cues in the same way as non-autistic adults, but this information is not then used to update mental representations. Our findings further document that many autistic people struggle to spontaneously mentalize others' beliefs, and this non-verbal paradigm holds promise for use with a wide range of ages and abilities.
Citation Count: 19
Docking of novel reversible monoamine oxidase-B inhibitors
(Springer Wien, 2007) Yelekci, K.; Karahan, O.; Toprakci, M.
Monoamine oxidase (MAO, EC 1.4.3.4) is a flavoenzyme bound to the mitochondrial outer membranes of the cells, which is responsible for the oxidative deamination of neurotransmitter and dietary amines. It has two distinct isozymic forms, designated MAO-A and MAO-B, each displaying different substrate and inhibitor specificities. They are the well-known target for antidepressant, Parkinson's disease and neuroprotective drugs. Elucidation of the x-ray crystallographic structure of MAO-B has opened the way for molecular modeling studies. In this research 12 reversible and MAO-B selective inhibitors have been docked computationally to the active site of the MAO-B enzyme. AutoDock 3.0.5 was employed to perform the automated molecular docking. The result of docking studies generated thermodynamic properties, such as free energy of bindings (Delta G(b)) and inhibition constants (K-i) for the inhibitors. Moreover, 3D pictures of inhibitor-enzyme complexes afforded valuable data regarding the binding orientation of each inhibitor in the active site of MAO-B.
Citation Count: 0
Dynamics of Feline Coronavirus and FIP: A Compartmental Modeling Approach
(Hindawi Ltd, 2023) Bilge, Ayşe Hümeyra; Bayrakal, Alper; Or, Mehmet Erman; Bilge, Ayse Humeyra
The investigation of infectious agents invading human and nonhuman populations represents a rich research domain within the framework of mathematical biology, captivating the interest of scientists across various disciplines. In this work, we examine the endemic equilibrium of feline coronavirus and feline infectious peritonitis by using a modified susceptible-infected-susceptible epidemiological model. We incorporate the concept of mutations from FCoV to FIP to enrich our analysis. We establish that the model, when subjected to reasonable parameter ranges, supports an endemic equilibrium wherein the FCoV group dominates. To demonstrate the stability of the equilibria under typical parameters and initial conditions, we employ the model SCF presented by Dobie in 2022 (Dobie, 2022). We ascertain that the equilibrium values reside within the interior domains of stability. Additionally, we displayed perturbed solutions to enhance our understanding. Remarkably, our findings align qualitatively with existing literature, which reports the prevalence of seropositivity to FCoV among stray cats (Tekelioglu et al. 2015, Oguzoglu et al. 2010, Pratelli 2008, Arshad et al. 2004).
Citation Count: 0
Effective health communication depends on the interaction of message source and content: two experiments on adherence to COVID-19 measures in Türkiye
(Taylor & Francis Ltd, 2023) Yılmaz, Onurcan; Aktar, Bengi; Aydas, Berke; Yilmaz, Onurcan; Alper, Sinan; Isler, Ozan
ObjectiveFollowing the COVID-19 outbreak, authorities recommended preventive measures to reduce infection rates. However, adherence to calls varied between individuals and across cultures. To determine the characteristics of effective health communication, we investigated three key features: message source, content, and audience.MethodsUsing a pre-test and two experiments, we tested how message content (emphasizing personal or social benefit), audience (individual differences), message source (scientists or state officials), and their interaction influence adherence to preventive measures. Using fliers advocating preventive measures, Experiment 1 investigated the effects of message content and examined the moderator role of individual differences. Experiment 2 presented the messages using news articles and manipulated sources.ResultsStudy 1 found decreasing adherence over time, with no significant impact from message content or individual differences. Study 2 found messages emphasizing 'protect yourself' and 'protect your country' to increase intentions for adherence to preventive measures. It also revealed an interaction between message source and content whereby messages emphasizing personal benefit were more effective when they came from healthcare professionals than from state officials. However, message source and content did not affect vaccination intentions or donations for vaccine research.ConclusionEffective health communication requires simultaneous consideration of message source and content.
Citation Count: 1
Effects of color cues on eye-hand coordination training with a mirror drawing task in virtual environment
(Frontiers Media Sa, 2024) Manav, Banu; Batmaz, Anıl Ufuk; Manav, Banu; Batmaz, Anil Ufuk
Mirror drawing is a motor learning task that is used to evaluate and improve eye-hand coordination of users and can be implemented in immersive Virtual Reality (VR) Head-Mounted Displays (HMDs) for training purposes. In this paper, we investigated the effect of color cues on user motor performance in a mirror-drawing task between Virtual Environment (VE) and Real World (RW), with three different colors. We conducted a 5-day user study with twelve participants. The results showed that the participants made fewer errors in RW compared to VR, except for pre-training, which indicated that hardware and software limitations have detrimental effects on the motor learning of the participants across different realities. Furthermore, participants made fewer errors with the colors close to green, which is usually associated with serenity, contentment, and relaxation. According to our findings, VR headsets can be used to evaluate participants' eye-hand coordination in mirror drawing tasks to evaluate the motor-learning of participants. VE and RW training applications could benefit from our findings in order to enhance their effectiveness.
Citation Count: 0
An efficient PanAir integrated framework for automated analysis
(Nature Portfolio, 2024) Gürkan, Ceren; Gurkan, Ceren
The work proposed here is an automated pre and post-processor integrated to PanAir that is is a high-order aerodynamic panel method-based software for flow analysis developed in 70s but still in active use especially for preliminary aircraft design. With the integrated environment proposed in this work, manipulation of input and output data to and from PanAir is bypassed successfully that is otherwise requires manual manipulations and use of third party software. The integrated environment is validated over a Cessna 210 aircraft with a modified NLF (1)-0414 airfoil. The flow around the aircraft is analyzed using PanAir together with the integrated environment and results show that pre and post processing times reduced and ease in PanAir use is increased significantly.
Citation Count: 0
Enhancing portfolio management using artificial intelligence: literature review
(Frontiers Media Sa, 2024) Sutiene, Kristina; Schwendner, Peter; Sipos, Ciprian; Lorenzo, Luis; Mirchev, Miroslav; Lameski, Petre; Cerneviciene, Jurgita
Building an investment portfolio is a problem that numerous researchers have addressed for many years. The key goal has always been to balance risk and reward by optimally allocating assets such as stocks, bonds, and cash. In general, the portfolio management process is based on three steps: planning, execution, and feedback, each of which has its objectives and methods to be employed. Starting from Markowitz's mean-variance portfolio theory, different frameworks have been widely accepted, which considerably renewed how asset allocation is being solved. Recent advances in artificial intelligence provide methodological and technological capabilities to solve highly complex problems, and investment portfolio is no exception. For this reason, the paper reviews the current state-of-the-art approaches by answering the core question of how artificial intelligence is transforming portfolio management steps. Moreover, as the use of artificial intelligence in finance is challenged by transparency, fairness and explainability requirements, the case study of post-hoc explanations for asset allocation is demonstrated. Finally, we discuss recent regulatory developments in the European investment business and highlight specific aspects of this business where explainable artificial intelligence could advance transparency of the investment process.
Citation Count: 2
Evaluation of the Potential Therapeutic Properties of Liquidambar orientalis Oil
(Wiley-v C H verlag Gmbh, 2023) Baloglu, Mehmet Cengiz; Yildiz Ozer, Lutfiye; Pirci, Buket; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Altunoglu, Yasemin Celik
Liquidambar orientalis Mill., commonly called the Anatolian sweetgum or Sigla tree, is endemic to southwestern Turkey. It has been historically significant in traditional medicine. In our research, we delved into the therapeutic attributes of its oil, emphasizing its antioxidant, antimicrobial, and antitumor properties. The primary chemical constituent of the gum is styrene, accounting for 78.5 %. The gum demonstrated antioxidant capabilities in several assays, including in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2 '-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP). It displayed bactericidal actions against various gram-positive bacteria, such as Staphylococcus aureus, and gram-negative strains, including Escherichia coli. Additionally, the oil showcased potent antitumor effects against breast (MDA-MB-231), lung (A549), and prostate (PC3) cancer cell lines. These effects were found to be both time- and dose-dependent. L. orientalis Mill. oil showed the best antitumor activity against breast, lung, and prostate cancer cell lines after the 24 h and 48 h treatment. Its oil might induce autophagy in the PC3 prostate cancer cell line, whereas its cytotoxicity against MDA-MB-231 and A549 cancer cell lines might not be correlated with autophagy or apoptosis pathways. In conclusion, the oil from the Sigla tree offers promising therapeutic potential and warrants further exploration.
Citation Count: 0
Exploring the spatial mental associations of distinct food types
(Academic Press Ltd- Elsevier Science Ltd, 2024) Gökçe, Ahu; Gokce, Ahu
Previous research explored the spatial representations of healthy low -calorie and unhealthy high -calorie food items, revealing an association of healthy low -calorie food with left and top sides, and unhealthy/high-calorie food with right and top sides. This association, namely side bias, was limited to these specific categories leaving the representations of healthy high -calorie and unhealthy low -calorie food categories yet to be explored. Present study was designed to examine the spatial representation of four food categories (unhealthy low -calorie, unhealthy high -calorie, healthy low -calorie, healthy high -calorie) using a computerized food placement task. In Experiment 1, participants placed four food items from different categories into eight locations. In Experiment 2, identical task was used with the addition of centrally presented anchor food item to investigate the mental representation of food items in relation to each other. The frequency of placing food items in specific spatial locations were measured. The results of Experiment 1 provided partial support for side bias. However, the use of anchor items in Experiment 2 provided compelling evidence for vertical side bias, demonstrating consistent pattern of placing healthy foods on the upper sides and unhealthy foods on the lower sides. In both experiments, real -life food choices were examined to investigate whether the high -calorie bias would be observed in actual food choice behavior. The results from both experiments indicated strong preference to select high -calorie foods, supporting high -calorie bias. Overall, this study extends the evidence on the spatial representations of distinct food categories.
Citation Count: 0
Facial basis of stereotypes: Judgements of warmth and competence based on cross-group typicality/distinctiveness of faces
(Wiley, 2024) Saribay, S. Adil; Pokorny, Simon; Turecek, Petr; Kleisner, Karel
Human migration is an increasingly common phenomenon and migrants are at risk of disadvantageous treatment. We reasoned that migrants may receive differential treatment by locals based on the closeness of their facial features to the host average. Residents of T & uuml;rkiye, the country with the largest number of refugees currently, served as participants. Because many of these refugees are of Arabic origin, we created target facial stimuli varying along the axis connecting Turkish and Arabic morphological prototypes (excluding skin colour) computed using geometric morphometrics and available databases. Participants made judgements of two universal dimensions of social perception-warmth and competence-on these faces. We predicted that participants judging faces manipulated towards the Turkish average would provide higher warmth and competence ratings compared to judging the same faces manipulated towards the Arabic average. Bayesian statistical tools were employed to estimate parameter values in multilevel models with intercorrelated varying effects. The findings did not support the prediction and revealed raters (as well as target faces) to be an important source of variation in social judgements. In the absence of simple cues (e.g. skin colour, group labels), the effect of facial morphology on social judgements may be much more complex than previously assumed.
Citation Count: 1
The flashbulb-like nature of memory for the first COVID-19 case and the impact of the emergency. A cross-national survey
(Routledge Journals, Taylor & Francis Ltd, 2024) Lanciano, Tiziana; Alfeo, Federica; Curci, Antonietta; Marin, Claudia; D'Uggento, Angela Maria; Decarolis, Diletta; Zheng, Jin
Flashbulb memories (FBMs) refer to vivid and long-lasting autobiographical memories for the circumstances in which people learned of a shocking and consequential public event. A cross-national study across eleven countries aimed to investigate FBM formation following the first COVID-19 case news in each country and test the effect of pandemic-related variables on FBM. Participants had detailed memories of the date and others present when they heard the news, and had partially detailed memories of the place, activity, and news source. China had the highest FBM specificity. All countries considered the COVID-19 emergency as highly significant at both the individual and global level. The Classification and Regression Tree Analysis revealed that FBM specificity might be influenced by participants' age, subjective severity (assessment of COVID-19 impact in each country and relative to others), residing in an area with stringent COVID-19 protection measures, and expecting the pandemic effects. Hierarchical regression models demonstrated that age and subjective severity negatively predicted FBM specificity, whereas sex, pandemic impact expectedness, and rehearsal showed positive associations in the total sample. Subjective severity negatively affected FBM specificity in Turkey, whereas pandemic impact expectedness positively influenced FBM specificity in China and negatively in Denmark.
Citation Count: 7
Gastrointestinal: Epiploic appendagitis
(Blackwell Publishing, 2005) Kantarci,M.; Duran,C.; Sirvanci,M.
[No abstract available]

Browse

Browsing PubMed İndeksli Yayınlar Koleksiyonu by Department "Kadir Has University"