PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://gcris.khas.edu.tr/handle/20.500.12469/4466

Browse

Now showing 1 - 20 of 85

Citation - WoS: 82
Citation - Scopus: 85
Addressing Climate Change With Behavioral Science: a Global Intervention Tournament in 63 Countries
(Amer Assoc Advancement Science, 2024) Vlasceanu, Madalina; Doell, Kimberly C.; Bak-Coleman, Joseph B.; Todorova, Boryana; Berkebile-Weinberg, Michael M.; Grayson, Samantha J.; Van Bavel, Jay J.
Effectively reducing climate change requires marked, global behavior change. However, it is unclear which strategies are most likely to motivate people to change their climate beliefs and behaviors. Here, we tested 11 expert-crowdsourced interventions on four climate mitigation outcomes: beliefs, policy support, information sharing intention, and an effortful tree-planting behavioral task. Across 59,440 participants from 63 countries, the interventions' effectiveness was small, largely limited to nonclimate skeptics, and differed across outcomes: Beliefs were strengthened mostly by decreasing psychological distance (by 2.3%), policy support by writing a letter to a future-generation member (2.6%), information sharing by negative emotion induction (12.1%), and no intervention increased the more effortful behavior-several interventions even reduced tree planting. Last, the effects of each intervention differed depending on people's initial climate beliefs. These findings suggest that the impact of behavioral climate interventions varies across audiences and target behaviors.
Citation - WoS: 1
The association of HLA-DRB1 alleles and MBL2 gene variant in pediatric acute lymphoblastic leukemia patients
(Elsevier, 2024) Oguz, Rustu; Ciftci, Hayriye Senturk; Gokce, Muge; Ogret, Yeliz; Karadeniz, Sedat; Pehlivan, Sacide; Ayd, Filiz
Introduction: Epidemio logic studies on pediatric acute lymphoblastic leukemias (ALL) have been conducted to evaluate the possible risk factors including genetic, infectious and environmental factors with the objective of idenfying the etiology. Mannose-binding lectin 2 (MBL2) plays an important role in first-line immune defense. HLA DRB1 alleles play a role in presentation of peptides to T cells and in activation of the adaptive immune response. Objective: In our study, we aimed to investigate both the MBL2 gene variant and HLA-DRB1 alleles in pediatric ALL patients. Materials: In this study, 86 high-risk ALL patients and 100 controls were included. Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (PCR-RFLP) and PCRsequence specific primer (SSP) methods were used for detection of polymorphism of the MBL2 and HLA-DRB1 alleles, respectively. Results: The frequency of the MBL2 AB genotype was lower in female ALL patients, compared to male ALL patients (p = 0.034). An association was found between the MBL2 BB genotype and DRB1*07 and among patients with the MBL2 BB genotype; those who also carried the DRB1*07 and *04 alleles were significantly higher than those without the DRB1*07 and *04 alleles. (p = 0.048, p = 0.022, respectively). Conclusion: This is the first study suggesting that the MBL2 BB genotype in association with the DRB1*07 or co-inheritance of the HLA-DRB1*04 and HLA DRB1*07 may have an impact on the etiopathogenesis of the disease. (c) 2023 Associa & ccedil;& atilde;o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Citation - WoS: 0
Citation - Scopus: 1
Background Tv and Infant-Family Interactions: Insights From Home Observations
(Wiley, 2024) Uzundag, Berna A.; Arslan Uzundağ, Berna; Koskulu-Sancar, Suemeyye; Kuntay, Aylin C.; Psychology
Background television has been found to negatively impact children's language development and self-regulatory skills, possibly due to decreased parent-child interactions. Most of the research on the relationship between background TV and caregiver-child interactions has been conducted in laboratory settings. In the current study, we conducted home observations and investigated whether infants engage in fewer interactions with family members in homes where background TV is more prevalent. We observed 32 infants at the ages of 8, 10, and 18 months in their home environments, coding for dyadic interactions (e.g., parent talking to and/or engaging with the child), triadic interactions (e.g., parent and infant play with a toy together), and infants' individual activities. Our findings revealed that background TV was negatively associated with the time infants spent in triadic interactions, positively associated with time spent engaging in individual activities, and not significantly related to the time spent in dyadic interactions. Apart from the relationship between background TV and individual activity time at 8 months, these associations remained significant even after accounting for families' socioeconomic status. These findings imply a correlation between background TV exposure and caregiver-infant-object interactions, warranting a longitudinal analysis with larger sample sizes.
Citation - WoS: 1
Citation - Scopus: 1
Behavioral but Not Psychological Control Predicts Self-Regulation, Adjustment Problems and Academic Self-Efficacy Among Early Adolescents
(Routledge Journals, Taylor & Francis Ltd, 2025) Harma, Mehmet; Aktas, Busra; Sumer, Nebi; Psychology
Prior work has documented that parental psychological and behavioral control have varying impacts on self-regulation skills and social-academic outcomes in early adolescence, with effects differing across cultures. The present study explores the role of psychological and behavioral control in predicting adjustment difficulties and academic self-confidence through self-regulatory skills among early adolescents in Turkiye using data from mothers and their children (N = 295, Ngirls=145, Mage=12.14 years). The results yielded that parental behavioral control, but not psychological control, predicts self-regulation of adolescents, which, in turn, predicts adjustment and academic self-efficacy. Our results underscore the pivotal role of parental knowledge and monitoring, mainly through behavioral control strategies, in fostering psychological adjustment and academic self-efficacy in the Turkish cultural context. The discussion delves into the potential culture-specific effects of psychological control and the universal influence of behavioral control during early adolescence.
Citation - Scopus: 9
Beyond Sightseeing: How Can Tourism Affect Public/Global Health in Modern Society?
(University of Edinburgh, 2022) Wen,J.; Kozak, Metin; Kozak,M.; Jiang,Y.; Advertising
[No abstract available]
Citation - WoS: 0
Can Reflection Mitigate Covid-19 Vaccine Conspiracy Beliefs and Hesitancy
(Taylor & Francis Ltd, 2025) Yılmaz, Onurcan; Sarıbay, Selahattin Adil; Ozman, Nagihan; Yilmaz, Onurcan; Isler, Ozan; Saribay, S. Adil; Psychology
Objective design:Periods of social turmoil, such as the COVID-19 pandemic, tend to amplify conspiracy beliefs, evidenced by increased vaccine hesitancy. Despite this trend, effective interventions targeting vaccine-related conspiracy beliefs remain scarce, partly due to underexplored cognitive processes. Three competing theoretical accounts offer differing predictions about the role of reflective thinking in supporting conspiracy beliefs: the Motivated Reasoning Account suggests reflection strengthens commitment to pre-existing attitudes; the Reflective Reasoning Account posits that reflection enhances belief accuracy; and the Reflective Doubt Account proposes reflection fosters general scepticism. Main outcome measures:Utilising open science practices and a validated technique to activate reflection, we conducted an experimental investigation with a diverse sample (N = 1483) segmented by vaccine attitudes. We investigated the impact of reflection on specific and generic COVID-19 conspiracy beliefs and vaccine-support behaviours across pro-vaccine, neutral, and vaccine-hesitant groups, while examining the moderating effects of scientific literacy, intellectual humility, and actively open-minded thinking. Results:The confirmatory analysis provided no direct support for the theoretical predictions. However, findings indicated that intellectual humility significantly moderated the effect of reflection, enhancing vaccine-support behaviour among participants with high intellectual humility, highlighting the complex interplay of cognitive style and prior attitudes in shaping responses to conspiracy beliefs and vaccine-support actions. Conclusion:The study highlights that while reflective thinking alone did not directly influence vaccine support behavior, its positive effect emerged among individuals with higher intellectual humility, emphasizing the importance of individual differences in shaping belief-related outcomes.
Citation - WoS: 0
Citation - Scopus: 0
Children's Questions and Teachers' Responses About Covid-19 in Türkiye and the Us
(Public Library Science, 2024) Unlutabak, Burcu; Trujillo Hernandez, Graciela; Velioglu, Ilayda; Menendez, David; Rosengren, Karl S.
Question-asking is a crucial tool for acquiring information about unseen entities, such as viruses; thus, examining children's questions within the context of COVID-19 is particularly important for understanding children's learning about the coronavirus. The study examined 3-12-year-old children's questions and teachers' responses about the COVID-19 pandemic in T & uuml;rkiye, a non-Western developing context, and the United States, a Western cultural context. A total of 119 teachers from T & uuml;rkiye and 95 teachers from the US participated in the study. Teachers completed an online survey consisting of a demographic form and a questionnaire asking them to report three questions about COVID-19 asked by children in their classrooms and their responses to these questions. We analyzed children's questions and teachers' responses for their type and content and examined demographic factors associated with children's questions and teachers' responses. Consistent with the literature, children from T & uuml;rkiye asked fewer explanation-seeking (i.e., why/how) questions than children from the United States. Children asked questions about viruses and precautions. Teachers responded to children's questions realistically in both countries. The findings have important implications for how children gain knowledge from teachers when discussing health, disease, and virus topics in two countries.
Citation - Scopus: 10
Comparison of Intraoperative Transit-Time Flow Measurement With Early Postoperative Magnetic Resonance Flow Mapping: in Off-Pump Coronary Artery Surgery
(2003) Sanisoglu,I.; Guden,M.; Balci,C.; Sagbas,E.; Duran,C.; Akpinar,B.
The purpose of this prospective study was to evaluate graft patency of off-pump coronary artery surgery intraoperatively by transit-time flow measurement and to compare this technique with postoperative magnetic resonance flow mapping. Twenty patients (13 men and 7 women; mean age, 67.9 ± 7.6 yr) underwent off-pump coronary artery surgery. Intraoperative transit-time flow measurement of grafts was performed measuring maximum, minimum, and mean flows. For each graft, the pulsatile index was calculated by dividing the difference between the maximum and the minimum flow by the mean flow. In the early postoperative period (1st week), magnetic resonance flow mapping was performed using phase contrast flow quantification. Mean intraoperative flow values and mean magnetic resonance flow mapping values were compared. At the same postoperative session, contrast-enhanced magnetic resonance angiography was performed to evaluate graft patency. In 20 patients, a total of 49 coronary graft flows were assessed with intraoperative transit-time flow measurement and postoperative magnetic resonance flow mapping. Upon comparison, there was a strong correlation between techniques, with stable and statistically significant differences between the intraoperative and postoperative flow mapping values. One saphenous vein graft was revised intraoperatively, due to graft failure. Our data suggest that the combined use of intraoperative transit-time flow measurement and postoperative magnetic resonance flow analysis has a potential role in the assessment of graft patency in off-pump coronary artery surgery, although more study is required.
Citation - WoS: 1
Citation - Scopus: 1
Composite Hydrogel of Polyacrylamide/Starch as a Novel Amoxicillin Delivery System
(Mdpi, 2024) Özuğur Uysal, Bengü; Pekcan, Mehmet Önder; Hassan, Gana; Alayoubi, Oubadah; Uysal, Bengu Ozugur; Pekcan, Onder; Molecular Biology and Genetics
This study investigates the development and characterization of a novel composite hydrogel composed of polyacrylamide (PAAm), starch, and gelatin for use as an amoxicillin delivery system. The optical properties, swelling behavior, and drug release profile of the composite hydrogel's were studied to evaluate its efficacy and potential applications. UV-visible spectroscopy was employed to determine the optical properties, revealing significant transparency in the visible range, which is essential for biomedical applications. The incorporation of starch and gelatin into the polyacrylamide matrix significantly enhanced the hydrogel's swelling capacity and biocompatibility. Studies on drug delivery demonstrated a sustained release profile of amoxicillin in simulated gastrointestinal fluids, which is essential for maintaining therapeutic levels for a prolonged amount of time. The results indicate that the composite hydrogel of PAAm/starch/gelatin has good swelling behavior, appealing optical characteristics, and a promising controlled drug release mechanism. These results point to this hydrogel's considerable potential as a drug delivery method, providing a viable path toward enhancing the medicinal effectiveness of amoxicillin and maybe other medications.
Citation - Scopus: 17
Corneal Ring Segments (intacs) for the Treatment of Asymmetrical Astigmatism of the Keratoconus. Follow-Up After 2 Years;
(2003) Tunc,Z.; Deveci,N.; Sener,B.; Bahcecioglu,H.
Objective: To evaluate the use of corneal ring segments (INTACS) for the treatment of asymmetrical astigmatism in keratoconus. Material and methods: This prospective study involved nine eyes of seven patients who were operated on between December 1998 and June 2000. A case of keratoconus with opacified cornea was excluded from this study. The patients chosen were contact lens-intolerant. The surgical intervention was carried out under topical anesthesia. The INTACS (Addition Technology) corneal ring insert was inserted approximately 68% of the peripheral corneal depth and was centered to the cone of the cornea. Results: No intraoperative complications occurred. We noted a flattening of the central cornea and a decrease in irregular astigmatism for all patients. Mean preoperative uncorrected visual acuity was less than 1/10. Postoperatively two eyes had an uncorrected visual acuity of 10/10, seven eyes showed an improvement from an uncorrected visual acuity of 2/10 to 7/10. Conclusion: We have observed that the flattening effect of INTACS inserts on the soft corneal keratoconic tissue and on the high astigmatic tissue seems greater than that produced in normal cornea. Implantation of INTACS resulted in a significant reduction in asymmetrical astigmatism of the keratoconus.
Citation - WoS: 3
Citation - Scopus: 3
Cultural Context Shapes the Selection and Adaptiveness of Interpersonal Emotion Regulation Strategies
(Amer Psychological Assoc, 2024) Pruessner, Luise; Altan-Atalay, Ayse
In everyday life, we commonly experience, express, and regulate our emotions in interpersonal contexts. However, much of the existing research on utilizing others for modulating one's emotions has focused on Western, individualistic cultures, leaving a significant gap in understanding how the selection and adaptiveness of interpersonal emotion regulation (IER) strategies vary across cultural contexts. This cross-national comparison study aims to bridge this gap by examining intrinsic IER in 1,187 participants from Turkey and Germany, which are characterized by different cultural norms, values, and socialization practices regarding emotional experience and expression. All participants completed measures of intrinsic IER strategies alongside measures of adaptive outcomes, including depression, anxiety, negative affect, and positive affect. The results revealed cross-national differences between Turkish and German individuals in terms of the intrinsic IER strategies most frequently selected and their associations with depression, anxiety, negative affect, and positive affect. These findings emphasize the significance of cultural context in intrinsic IER and offer insights into the conditions under which these strategies are linked to adaptive outcomes. By recognizing the cultural nuances in how people navigate their emotions via social interactions, clinicians and researchers can develop more culturally sensitive interventions tailored to the specific needs of individuals in diverse cultural contexts.
Citation - WoS: 0
Citation - Scopus: 0
Decision Making, Emotion Recognition and Childhood Traumatic Experiences in Murder Convicts Imprisoned With Aggravated Life Sentence: a Prison Study
(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Derneği, 2025) Cikrikcili, Ugur; Yildirim, Elif; Buker, Seda; Ger, Can; Erozden, Ozan; Gurvit, Hakan; Saydam, Bilgin
Introduction: Decision-making and emotion recognition are two fundamental themes in social cognition. Disorders in these areas can lead to interpersonal, psychosocial, and legal problems for the individual and society. The likelihood of consequent aggression and crime makes them foci of forensic psychiatry over time. In this study, two developmental disorders that have a clear relationship with crime, that are antisocial personality disorder (ASPD), and psychopathy are investigated for their relationship with these social cognitive deficits. Methods: The present study involved 23 male prison inmates who were diagnosed with both antisocial personality disorder and psychopathy, as well as 23 control participants who were matched for age, gender, and level of education. Following the psychiatric interview, Reading the Mind in the Eyes Test (RMET), the Iowa Gambling Test (IGT), Toronto Alexithymia Scale (TAS), Defense Styles Questionnaire (DSQ), Childhood Psychic Trauma Scale (CTQ), Hare Psychopathy Checklist (PCL-R) were administered to all participants. Results: The results of the study showed that ASPD group performed statistically worse than healthy controls in TAS, CTQ, all items of DSQ, PCL-R Factor 1 and 2, and all the IGT scores (p<0.05). There were no statistically significant difference between in the RMETtest performances Conclusion: These results suggest that ASPD and psychopathy lead to impaired decision-making behaviors due to the inability to recognize one's own emotions and impulsivity, and that these characteristics play a critical role in the criminal behavior of individuals. In addition, contrary to expectations, the results of affective theory of mind assessed with the RMET showed similar characteristics in homicide convicts and healthy controls. These data indicate the need for further research in the field of forensic psychiatry.
Citation - WoS: 1
Citation - Scopus: 1
Deviation From the Balanced Time Perspective and Depression and Anxiety Symptoms: the Mediating Roles of Cognitive-Behavioral Emotion Regulation in a Cross-Cultural Model
(Frontiers Media Sa, 2025) Ranjbar, Hamed Abdollahpour; Altan-Atalay, Ayse; Asgarabad, Mojtaba Habibi; Turan, Bulent; Eskin, Mehmet
Background Time perspective (TP) influences how individuals perceive and classify their past, present, and future, impacting their cognition, behavior, and psychological outcomes. Deviation from the balanced time perspective (DBTP) is associated with mental health problems (e.g., depression and anxiety). Emotion regulation (ER) encompasses cognitive and behavioral processes to regulate emotions, with maladaptive strategies like rumination and withdrawal linked to depression and anxiety. Despite extensive research on TP and ER, their joint impact, particularly in the context of depression and anxiety, and cultural differences remain underexplored.Method Participants (N = 513 Iranian, N = 470 Turkish) completed self-report questionnaires on time perspective, cognitive and behavioral ER, anxiety, and depression symptoms. A moderated mediation model was assessed, incorporating the exogenous variable of DBTP, with ER strategies as mediators, and endogenous variables of depressive and anxiety symptoms. The model accounted for cultural variations in the paths as a moderator.Results Significant associations were found between DBTP, ER strategies, depression, and anxiety symptoms. Mediation analyses revealed that both cognitive and behavioral ER strategies (except for adaptive behavioral ER strategies) significantly mediated the associations between DBTP and depression and anxiety. Additionally, multigroup analyses suggested that these mediating effects were consistent across Iranian and Turkish samples, with exceptions in adaptive cognitive ER strategies.Conclusion The study highlights the crucial role of TPs and ER strategies in predicting anxiety and depression symptoms, with notable cultural nuances. Specifically, maladaptive strategies exacerbate symptoms, while adaptive strategies mitigate them primarily in Iranian contexts. Cultural subtleties are discussed in detail.
Citation - WoS: 0
Citation - Scopus: 0
Differentiating Functional Connectivity Patterns in Adhd and Autism Among the Young People: a Machine Learning Solution
(Sage Publications inc, 2025) Ballı, Tuğçe; Balli, Tugce; Roeyers, Herbert; Wiersema, Jan R.; Camkerten, Sami; Ozturk, Ozan Cem; Sonuga-Barke, Edmund; Management Information Systems
Objective: ADHD and autism are complex and frequently co-occurring neurodevelopmental conditions with shared etiological and pathophysiological elements. In this paper, we attempt to differentiate these conditions among the young people in terms of intrinsic patterns of brain connectivity revealed during resting state using machine learning approaches. We had two key objectives: (a) to determine the extent to which ADHD and autism could be effectively distinguished via machine learning from one another on this basis and (b) to identify the brain networks differentially implicated in the two conditions.Method: Data from two publicly available resting-state functional magnetic resonance imaging (fMRI) resources-Autism Brain Imaging Data Exchange (ABIDE) and the ADHD-200 Consortium-were analyzed. A total of 330 participants (65 females and 265 males; mean age = 11.6 years), comprising equal subgroups of 110 participants each for ADHD, autism, and healthy controls (HC), were selected from the data sets ensuring data quality and the exclusion of comorbidities. We identified region-to-region connectivity values, which were subsequently employed as inputs to the linear discriminant analysis algorithm.Results: Machine learning models provided strong differentiation between connectivity patterns in participants with ADHD and autism-with the highest accuracy of 85%. Predominantly frontoparietal network alterations in connectivity discriminate ADHD individuals from autism and neurotypical group. Networks contributing to discrimination of autistic individuals from neurotypical group were more heterogeneous. These included language, salience, and frontoparietal networks.Conclusion: These results contribute to our understanding of the distinct neural signatures underlying ADHD and autism in terms of intrinsic patterns of brain connectivity. The high level of discriminability between ADHD and autism, highlights the potential role of brain based metrics in supporting differential diagnostics.
Citation - WoS: 0
Citation - Scopus: 0
Distinct Deregulation Trends of Transcriptional Protein Complexes in Aging Naive T Cells
(Oxford University Press, 2025) Kökrek, E.; Kökrek, Emel; Pir, P.; Molecular Biology and Genetics
The impact of aging on T cell subsets, specifically CD4+ and CD8+ T cells, leading to immune system dysfunction has been the focus of scientific investigation due to its potential to reverse age-associated deterioration. Transcriptomic and epigenomic studies have identified the primary regulators in T cell aging. However, comprehending the underlying dynamic mechanisms requires studying these proteins with their interactors. Here, we integrated single-cell RNA sequencing data of naive CD4+ and CD8+ T cells obtained from 3 different age groups with protein-protein and domain-domain interaction networks to predict and compare the transcriptional protein complexes and identify their capacity to explain age-associated variances. Our novel approach revealed significant effects of aging on the repertoire of complexes, which remains unchanged in naive CD4+ T cells, while in naive CD8+ T cells, it diminishes. In both cell types, there was major deregulation of complexes with the same composition, involving a range of transcription factors. This aging-associated deregulation is characterized by a specific set of protein complexes in naive CD4+ T cells, but this pattern is not observed in naive CD8+ T cells. SMAD3 and BCL11A complexes emerge as key markers in defining a trajectory in aging naive CD4+ T cells. These complexes can accurately distinguish between 3 different age groups, indicating their potential as targets. The direct link between SMAD3 and FOS complexes whose regulatory role has been previously implicated in aging and MBD3 as the novel key link between SMAD3 and BCL11A complexes implicates a coordinated mechanism in age-associated deregulation. © The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology.
Citation - WoS: 2
Citation - Scopus: 2
Do Autistic Adults Spontaneously Reason About Belief? a Detailed Exploration of Alternative Explanations
(Royal Soc, 2024) Wu, Ruihan; Lim, Jing Tian; Ahmed, Zahra; Berger, Rachael; Acem, Ensar; Chowdhury, Ishita; White, Sarah J.
Southgate et al.'s (Southgate 2007 Psychol. Sci. 18, 587-92 (doi:10.1111/j.1467-9280.2007.01944.x)) anticipatory-looking paradigm has presented exciting yet inconclusive evidence surrounding spontaneous mentalizing in autism. The present study aimed to develop this paradigm to address alternative explanations for the lack of predictive eye movements on false-belief tasks by autistic adults. This was achieved through implementing a multi-trial design with matched true-belief conditions, and both high and low inhibitory demand false-belief conditions. We also sought to inspect if any group differences were related to group-specific patterns of attention on key events. Autistic adults were compared with non-autistic adults on this adapted implicit mentalizing task and an established explicit task. The two groups performed equally well in the explicit task; however, autistic adults did not show anticipatory-looking behaviour in the false-belief trials of the implicit task. Critically, both groups showed the same attentional distribution in the implicit task prior to action prediction, indicating that autistic adults process information from social cues in the same way as non-autistic adults, but this information is not then used to update mental representations. Our findings further document that many autistic people struggle to spontaneously mentalize others' beliefs, and this non-verbal paradigm holds promise for use with a wide range of ages and abilities.
Citation - WoS: 20
Citation - Scopus: 22
Docking of Novel Reversible Monoamine Oxidase-B Inhibitors
(Springer Wien, 2007) Yelekci, K.; Karahan, O.; Toprakci, M.
Monoamine oxidase (MAO, EC 1.4.3.4) is a flavoenzyme bound to the mitochondrial outer membranes of the cells, which is responsible for the oxidative deamination of neurotransmitter and dietary amines. It has two distinct isozymic forms, designated MAO-A and MAO-B, each displaying different substrate and inhibitor specificities. They are the well-known target for antidepressant, Parkinson's disease and neuroprotective drugs. Elucidation of the x-ray crystallographic structure of MAO-B has opened the way for molecular modeling studies. In this research 12 reversible and MAO-B selective inhibitors have been docked computationally to the active site of the MAO-B enzyme. AutoDock 3.0.5 was employed to perform the automated molecular docking. The result of docking studies generated thermodynamic properties, such as free energy of bindings (Delta G(b)) and inhibition constants (K-i) for the inhibitors. Moreover, 3D pictures of inhibitor-enzyme complexes afforded valuable data regarding the binding orientation of each inhibitor in the active site of MAO-B.
Citation - WoS: 0
Citation - Scopus: 0
Dynamics of Feline Coronavirus and Fip: a Compartmental Modeling Approach
(Hindawi Ltd, 2023) Dobie, Ayse Peker; Bilge, Ayşe Hümeyra; Bayrakal, Alper; Or, Mehmet Erman; Bilge, Ayse Humeyra; Industrial Engineering
The investigation of infectious agents invading human and nonhuman populations represents a rich research domain within the framework of mathematical biology, captivating the interest of scientists across various disciplines. In this work, we examine the endemic equilibrium of feline coronavirus and feline infectious peritonitis by using a modified susceptible-infected-susceptible epidemiological model. We incorporate the concept of mutations from FCoV to FIP to enrich our analysis. We establish that the model, when subjected to reasonable parameter ranges, supports an endemic equilibrium wherein the FCoV group dominates. To demonstrate the stability of the equilibria under typical parameters and initial conditions, we employ the model SCF presented by Dobie in 2022 (Dobie, 2022). We ascertain that the equilibrium values reside within the interior domains of stability. Additionally, we displayed perturbed solutions to enhance our understanding. Remarkably, our findings align qualitatively with existing literature, which reports the prevalence of seropositivity to FCoV among stray cats (Tekelioglu et al. 2015, Oguzoglu et al. 2010, Pratelli 2008, Arshad et al. 2004).
Citation - WoS: 0
Citation - Scopus: 0
Economic Uncertainty and Climate Change Exposure
(Academic Press Ltd- Elsevier Science Ltd, 2025) Öztürk Danışman, Gamze; Erdoğan, Seda; Demir, Ender; International Trade and Finance
This paper explores how economic uncertainty affects firms' climate change exposure. We use an extensive sample from 24 countries from 2002 to 2021. Employing a novel measure of firm-level climate change exposure developed by Sautner et al. (2023b), we empirically demonstrate that prior to the Paris Agreement in 2015, economic uncertainty leads to a decrease in climate change disclosures. However, after the Paris Agreement, our findings reveal a positive association between economic uncertainty and climate change exposure. The positive disclosure effect is primarily driven by higher climate-related opportunities and regulatory exposures. Our findings are robust when we employ alternative definitions for economic uncertainty, alternative samples, additional firm-level and country-level control variables, and alternative methodologies. We find that institutional and foreign ownership positively moderates the association between economic uncertainty and climate change exposure after the Paris Agreement. Further analysis investigates the moderating impact of country-level environmental performance indicators. We present novel empirical evidence suggesting that firms operating in countries with less climate vulnerability, higher readiness, more stringent environmental policies, superior climate protection performance, and higher environmental litigation risk tend to have higher climate change exposure in uncertain times.
Citation - WoS: 0
Citation - Scopus: 0
Effective Drug Design Screening in Bacterial Glycolytic Enzymes Via Targeting Alternative Allosteric Sites
(Elsevier Science inc, 2024) Akdoğan, Ebru Demet; Kurtulus, Gamze; Sesal, Cenk; Kurkcuoglu, Ozge; Ayyildiz, Merve; Celiker, Serkan; Akten, Ebru Demet; Molecular Biology and Genetics
Three glycolytic enzymes phosphofructokinase (PFK), glyceraldehyde-3-phosphate dehydrogenase (GADPH) and pyruvate kinase (PK) that belong to Staphylococcus aureus were used as targets for screening a dataset composed of 7229 compounds of which 1416 were FDA-approved. Instead of catalytic sites, evolutionarily less conserved allosteric sites were targeted to identify compounds that would selectively bind the bacteria's glycolytic enzymes instead of the human host. Seven different allosteric sites provided by three enzymes were used in independent screening experiments via docking. For each of the seven sites, a total of 723 compounds were selected as the top 10 % which displayed the highest binding affinities. All compounds were then united to yield the top 54 drug candidates shared by all seven sites. Next, 17 out of 54 were selected and subjected to in vitro experiments for testing their inhibition capability for antibacterial growth and enzymatic activity. Accordingly, four compounds displaying antibacterial growth inhibition above 40 % were determined as Candesartan cilexetil, Montelukast (sodium), Dronedarone (hydrochloride) and Thonzonium (bromide). In a second round of experiment, Candesartan cilexetil and Thonzonium displayed exceptionally high killing efficiencies on two bacterial strains of S. aureus (methicillin-sensitive and methicillin-resistant) with concentrations as low as 4 mu g/mL and 0.5 mu g/mL. Yet, their enzymatic assays were not in accordance with their killing effectiveness. Different inhibitory effects was observed for each compound in each enzymatic assay. A more effective target strategy would be to screen for drug compounds that woud inhibit a combination of glycolytic enzymes observed in the glycolytic pathway.

Browse

Browsing PubMed İndeksli Yayınlar Koleksiyonu by Department "Kadir Has University"