PubMed İndeksli Yayınlar Koleksiyonu
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Article Citation - Scopus: 0Biocontrol Potential of Vibrio Maritimus Chitinase: Heterologous Expression and Insecticidal Activity Against Acanthoscelides Obtectus(Elsevier B.V., 2025) Dikbaş, N.; Tülek, A.; Uçar, S.; Alim,; Servili, B.; Paçal, N.; Ercisli, S.In this study, the chitinase gene from the marine bacterium Vibrio maritimus was heterologously expressed in Escherichia coli, purified via affinity chromatography and tested for its insecticidal activity against the storage pest Acanthoscelides obtectus. The recombinant VmChiA protein exhibited a molecular mass of ∼60 kDa, with optimum activity observed at pH 6.0 and 40 °C. Enzyme kinetic analysis revealed a Km value of 0.042 mM, Vmax of 17.48 μmol min−1, kcat of 1.75 min−1 and catalytic efficiency of 41.61 mM−1 min−1, respectively. Furthermore, a dose of 40 U mL−1 of recombinant VmChiA showed similar efficacy to malathion insecticide against A. obtectus, with 100 % mortality in both treatments. LC50 and LC90 values of VmChiA were 13.95 U mL−1 and 27.66 U mL−1, respectively. Furthermore, the three-dimensional structure of the catalytic site of VmChiA was modeled. Molecular dynamics simulation technique was used to explore and analyze the dynamics and interactions. A salt bridge (GLU274-ARG296) in the α + β domain was observed as a critical feature facilitating substrate (GlcNAc)2 binding and enzymatic activity. These findings demonstrate that recombinant VmChiA possesses potent insecticidal properties, highlighting its potential as a bio-based, eco-friendly alternative for managing significant agricultural pests. © 2025 Elsevier B.V.Article Citation - WoS: 0Citation - Scopus: 0The Associations Between Deviation From the Balanced Time Perspective and Depression and Anxiety: The Moderator Role of Mindfulness in a Two-Wave Study(Sage Publications inc, 2025) Altan-Atalay, Ayse; Ranjbar, Hamed Abdollahpour; Altintas, SedaDeviation from the balanced time perspective (DBTP) refers to difficulties in switching between different time frames in a flexible way by considering the situational demands. DBTP is associated with higher levels of depression and anxiety. Mindfulness acts as a protective mechanism against depression and anxiety. The current study examined the moderator role of mindfulness in the relationship between DBTP and psychological distress. The participants were 243 university students (53.09% women) between ages 18 and 29 (M = 19.88, SD = 1.42) who answered self-report measures of time perspective, mindfulness, anxiety, and depression at two-time points with a five-week time interval. The results showed that the interaction between DBTP and mindfulness measured at time one could prospectively predict both anxiety and depression measured at time two. Mindfulness plays a significant moderating role in the relationship between DBTP and anxiety and depression. The data indicate that for individuals with low levels of DBTP, those with higher mindfulness experience significantly lower anxiety and depression compared to those with lower mindfulness. However, as DBTP increases, anxiety and depression levels in the high mindfulness group rise significantly, ultimately converging with those observed in the low mindfulness group. This indicates that while high mindfulness offers buffering effects against anxiety and depression, these effects diminish under increased DBTP.Article Citation - WoS: 0Impact of Culture Shock, Acculturation Approaches, and Sociocultural Adaptation on Perceived Proficiency in Turkish and English Among International Students in Turkey(Elsevier, 2025) Tekel, Esra; Ergin-Kocaturk, Hatice; Su, Ahmet; Kocaturk, Metin; Caner, Mustafa; Karadag, EnginThe primary objective of this study was to investigate the influence of culture shock, acculturation strategies, and sociocultural adjustment on the perceived Turkish and English language proficiency of international students in Turkey. Data were collected from 3554 international students in Turkey whose native language was neither Turkish nor English, using the "Culture Shock Questionnaire", "Acculturation Measurement", and "Sociocultural Adjustment Scale". Data were analyzed using correlation and hierarchical multiple regression analyses. The results revealed that the perceived Turkish and English language proficiencies of international students in Turkey were moderate. Language proficiency, personal interests, and social participation factors of sociocultural adjustment and acculturation strategies, such as assimilation and integration, have a positive impact on perceived Turkish language proficiency. On the other hand, the interpersonal stress factor of culture shock and assimilation and integration aspects of the acculturation strategies were found to be the most critical determinants of perceived English language proficiency. Additionally, language proficiency, personal interests, and social participation factors of sociocultural adjustment and acculturation strategies, such as separation and assimilation, had positive effects, whereas the language proficiency factor of sociocultural adjustment and assimilation acculturation strategies had negative effects. The findings of this study indicate that acculturation strategies and sociocultural adjustment play a crucial role in the development of perceived target language proficiency.Article Citation - WoS: 0Citation - Scopus: 0Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors(Elsevier Ireland Ltd, 2025) Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Kucukguzel, S. . GunizIn the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.Article Citation - WoS: 0Citation - Scopus: 0Does Attention Sharing Support Attention Focusing? Investigating the Link Between Infants' Sustained Attention and Joint Attention With Caregivers(Elsevier Science inc, 2025) Uzundag, Berna A.Sustained attention in infancy is a known predictor of executive functions, self-regulation, and language. This study investigated the relationship between 9-to 16-month-old infants' sustained attention and joint attention in mother-infant dyads. Data were collected from 98 infants (M(SD) = 11.8(1.3) months) and their mothers. Results showed that joint attention during mother-infant play significantly predicted sustained attention during solo play, after accounting for infant age and socioeconomic status. These cross-sectional findings suggest that joint attention may play a role in supporting sustained attention, though the directionality of this relationship warrants further longitudinal investigation.Editorial Citation - WoS: 0Citation - Scopus: 0Miniaturized Soft Growing Robots for Minimally Invasive Surgeries: Challenges and Opportunities(Iop Publishing Ltd, 2025) Stroppa, Fabıo; Saraç Stroppa, Mine; Sarac, Mine; Mechatronics Engineering; Computer EngineeringAdvancements in assistive robots have significantly transformed healthcare procedures in recent years. Clinical continuum robots have enhanced minimally invasive surgeries, offering benefits to patients such as reduced blood loss and a short recovery time. However, controlling these devices is difficult due to their limited accuracy in three-dimensional deflections and challenging localization, particularly in confined spaces like human internal organs. Consequently, there has been growing research interest in employing miniaturized soft growing robots, a promising alternative that provides enhanced flexibility and maneuverability. In this work, we extensively investigated issues concerning their designs and interactions with humans in clinical contexts. We took insights from the open challenges of the generic soft growing robots to examine implications for miniaturization, actuation, and biocompatibility. We proposed technological concepts and provided detailed discussions on leveraging existing technologies, such as smart sensors, haptic feedback, and artificial intelligence, to ensure the safe and efficient deployment of the robots. Finally, we offer an array of opinions from a biomedical engineering perspective that contributes to advancing research in this domain for future research to transition from conceptualization to practical clinical application of miniature soft growing robots.Article Citation - WoS: 0Citation - Scopus: 0Reflective Thinking Predicts Disbelief in God Across 19 Countries(Springer, 2025) Yılmaz, Onurcan; Yilmaz, Onurcan; Isler, Ozan; Terry, Jenny; Ross, Robert M.; PsychologyIn the present study, we tested three hypotheses about relationships between reflective thinking, intuitive thinking (both measured using the Cognitive Reflection Test; CRT), and belief in God or gods (BiG) in university students across 19 culturally and geographically diverse countries (n = 7,771). In support of our first hypothesis, we found a negative relationship between reflective thinking and BiG; and in support of our second hypothesis, we found a positive relationship between intuitive thinking and BiG. Contrary to our third hypothesis, we found no evidence that measuring CRT prior to measuring BiG decreased BiG. Given that this is the first large cross-cultural test of these hypotheses to have a preregistered analysis plan, the first to hold education constant across countries, and the first to use both Bayesian and frequentist methods, these results considerably bolster the evidence in support of the first two hypotheses and against the third hypothesis.Article Citation - WoS: 0Can Reflection Mitigate Covid-19 Vaccine Conspiracy Beliefs and Hesitancy(Taylor & Francis Ltd, 2025) Yılmaz, Onurcan; Sarıbay, Selahattin Adil; Ozman, Nagihan; Yilmaz, Onurcan; Isler, Ozan; Saribay, S. Adil; PsychologyObjective design:Periods of social turmoil, such as the COVID-19 pandemic, tend to amplify conspiracy beliefs, evidenced by increased vaccine hesitancy. Despite this trend, effective interventions targeting vaccine-related conspiracy beliefs remain scarce, partly due to underexplored cognitive processes. Three competing theoretical accounts offer differing predictions about the role of reflective thinking in supporting conspiracy beliefs: the Motivated Reasoning Account suggests reflection strengthens commitment to pre-existing attitudes; the Reflective Reasoning Account posits that reflection enhances belief accuracy; and the Reflective Doubt Account proposes reflection fosters general scepticism. Main outcome measures:Utilising open science practices and a validated technique to activate reflection, we conducted an experimental investigation with a diverse sample (N = 1483) segmented by vaccine attitudes. We investigated the impact of reflection on specific and generic COVID-19 conspiracy beliefs and vaccine-support behaviours across pro-vaccine, neutral, and vaccine-hesitant groups, while examining the moderating effects of scientific literacy, intellectual humility, and actively open-minded thinking. Results:The confirmatory analysis provided no direct support for the theoretical predictions. However, findings indicated that intellectual humility significantly moderated the effect of reflection, enhancing vaccine-support behaviour among participants with high intellectual humility, highlighting the complex interplay of cognitive style and prior attitudes in shaping responses to conspiracy beliefs and vaccine-support actions. Conclusion:The study highlights that while reflective thinking alone did not directly influence vaccine support behavior, its positive effect emerged among individuals with higher intellectual humility, emphasizing the importance of individual differences in shaping belief-related outcomes.Article Citation - WoS: 0Citation - Scopus: 0Investigation of the Potential Effect of Complement 5 on Transplantation Outcome by Bioinformatics Tools(Iranian Soc Nephrolgy, 2025) Oguz, Suleyman Rustu; Kivanc, Demet; Ozdilli, Kursat; Karadeniz, Sedat; Kluge, Ekin Ece Gurer; Ciftci, Hayriye SenturkIntroduction. Activation of the complement system following transplantation may result in allograft rejection. Our study aimed to evaluate the potential relationship between factors affecting kidney transplant success and complement 5 (C5) using bioinformatic tools. Methods. GenCards and Genemania were used to provide the genetic functional information belonging to the C5 gene, and genomic browsers of STRING, UCSC, KEGG were used to reveal interactions with other genes and various pathways. MiRDB was used to specify the miRNAs that were associated with the C5 gene. The UniProt database was used to determine the tissues that expressed the C5 gene using protein-protein interactions. Results. In the bioinformatic analyses performed, high levels of C5 gene expression were found in the naiive kidney. Twenty-five genes were found to be strongly associated with C5. Fifty-four miRNAs targeting the C5 gene were specified. The C5 gene was found to be involved in biologic processes such as complement activation (FDR = 6.46e-22), complement binding (FDR = 2.20e-06), cytolysis (FDR = 4.82e-14), regulation of complement activation (FDR = 4.08e24), positive regulation of vascular endothelial growth factor production (FDR = 0.0430), regulation of macrophage chemotaxis (FDR = 0.0447), activation of the immune response (FDR = 1.26e13), leukocyte-mediated immunity (FDR = 1.41e-09), innate immune response (FDR = 3.05e-09), allograft rejection (FDR = 2.40e-12), oxidative injury response (FDR = 0.00016), and trigerring of the beginning of the complement cascade (FDR = 0.0244). Conclusions. The data obtained in this study will be used to guide future experimental investigations in the field of transplantation, and these data will give physicians with insight into allograft status following transplantation.Article Citation - WoS: 0Citation - Scopus: 0Decision Making, Emotion Recognition and Childhood Traumatic Experiences in Murder Convicts Imprisoned With Aggravated Life Sentence: a Prison Study(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Derneği, 2025) Cikrikcili, Ugur; Yildirim, Elif; Buker, Seda; Ger, Can; Erozden, Ozan; Gurvit, Hakan; Saydam, BilginIntroduction: Decision-making and emotion recognition are two fundamental themes in social cognition. Disorders in these areas can lead to interpersonal, psychosocial, and legal problems for the individual and society. The likelihood of consequent aggression and crime makes them foci of forensic psychiatry over time. In this study, two developmental disorders that have a clear relationship with crime, that are antisocial personality disorder (ASPD), and psychopathy are investigated for their relationship with these social cognitive deficits. Methods: The present study involved 23 male prison inmates who were diagnosed with both antisocial personality disorder and psychopathy, as well as 23 control participants who were matched for age, gender, and level of education. Following the psychiatric interview, Reading the Mind in the Eyes Test (RMET), the Iowa Gambling Test (IGT), Toronto Alexithymia Scale (TAS), Defense Styles Questionnaire (DSQ), Childhood Psychic Trauma Scale (CTQ), Hare Psychopathy Checklist (PCL-R) were administered to all participants. Results: The results of the study showed that ASPD group performed statistically worse than healthy controls in TAS, CTQ, all items of DSQ, PCL-R Factor 1 and 2, and all the IGT scores (p<0.05). There were no statistically significant difference between in the RMETtest performances Conclusion: These results suggest that ASPD and psychopathy lead to impaired decision-making behaviors due to the inability to recognize one's own emotions and impulsivity, and that these characteristics play a critical role in the criminal behavior of individuals. In addition, contrary to expectations, the results of affective theory of mind assessed with the RMET showed similar characteristics in homicide convicts and healthy controls. These data indicate the need for further research in the field of forensic psychiatry.Article Citation - WoS: 0Citation - Scopus: 0Structural Descriptors for Subunit Interface Regions in Homodimers: Effect of Lipid Membrane and Secondary Structure Type(American Chemical Society, 2025) Yüksek, A.; Yıkınç, B.; Nayır, I.; Alnıgeniş, D.; Fidan, V.G.; Topuz, T.; Akten, E.D.A total of 1311 homodimers were collected and analyzed in three different categories to highlight the impact of lipid environment and secondary structure type: 422 cytoplasmic α-helix, 411 cytoplasmic β-strand, and 478 membrane complexes. Structural features of the interface connecting two monomers were investigated and compared to those of the non-interface surface. Every residue on the surface of each monomer was explored based on four attributes: solvent-accessible surface area (SASA), protrusion index (Cx), surface planarity, and surface roughness. SASA and Cx distribution profiles clearly distinguished the interface from the surface in all categories, where the rim of the interface displayed higher SASA and Cx values than the rest of the surface. Surface residues in membrane complexes protruded less than cytoplasmic ones due to the hydrophobic environment, and consequently, the difference between surface and interface residues became less noticeable in that category. Cytoplasmic β-strand complexes displayed markedly lower SASA at the interface core than at the surface. The major distinction between the surface and interface was achieved through surface roughness, which displayed significantly higher values for the interface than the surface, especially in cytoplasmic complexes. Clearly, a surface which is relatively rugged favors the association of two monomers through multiple van der Waals interactions and hydrogen-bond formations. Another structural descriptor with strong distinguishing ability was surface planarity, which was higher at the interface than at the non-interface surface. Surface flatness would eventually facilitate the interconnectedness of an interface with a network of residue pairs bridging two complementary surfaces. Analysis of contact pairs revealed that hydrophobic pairs have the highest frequency of occurrence in the lipid environment of membrane complexes. However, despite the scarcity of polar residues at the interface, the likelihood of observing a contact between polar residues was markedly higher than that of hydrophobic ones. © 2025 The Authors. Published by American Chemical Society.Article Citation - WoS: 1Citation - Scopus: 1Behavioral but Not Psychological Control Predicts Self-Regulation, Adjustment Problems and Academic Self-Efficacy Among Early Adolescents(Routledge Journals, Taylor & Francis Ltd, 2025) Harma, Mehmet; Aktas, Busra; Sumer, Nebi; PsychologyPrior work has documented that parental psychological and behavioral control have varying impacts on self-regulation skills and social-academic outcomes in early adolescence, with effects differing across cultures. The present study explores the role of psychological and behavioral control in predicting adjustment difficulties and academic self-confidence through self-regulatory skills among early adolescents in Turkiye using data from mothers and their children (N = 295, Ngirls=145, Mage=12.14 years). The results yielded that parental behavioral control, but not psychological control, predicts self-regulation of adolescents, which, in turn, predicts adjustment and academic self-efficacy. Our results underscore the pivotal role of parental knowledge and monitoring, mainly through behavioral control strategies, in fostering psychological adjustment and academic self-efficacy in the Turkish cultural context. The discussion delves into the potential culture-specific effects of psychological control and the universal influence of behavioral control during early adolescence.Article Citation - WoS: 0Citation - Scopus: 0Quantum Models of Consciousness From a Quantum Information Science Perspective(Mdpi, 2025) Pusuluk, Onur; Pusuluk, Onur; Cattaneo, Marco; Muestecaplioglu, Ozgur E.; Core ProgramThis perspective explores various quantum models of consciousness from the viewpoint of quantum information science, offering potential ideas and insights. The models under consideration can be categorized into three distinct groups based on the level at which quantum mechanics might operate within the brain: those suggesting that consciousness arises from electron delocalization within microtubules inside neurons, those proposing it emerges from the electromagnetic field surrounding the entire neural network, and those positing it originates from the interactions between individual neurons governed by neurotransmitter molecules. Our focus is particularly on the Posner model of cognition, for which we provide preliminary calculations on the preservation of entanglement of phosphate molecules within the geometric structure of Posner clusters. These findings provide valuable insights into how quantum information theory can enhance our understanding of brain functions.Article Citation - WoS: 1Citation - Scopus: 1Hydrogels From Protein-Polymer Conjugates: a Pathway To Next-Generation Biomaterials(Mdpi, 2025) Pekcan, Mehmet Önder; Poyraz, Yagmur; Hassan, Gana; Gul, Sumeyye Berfin; Calhan, Nergiz; Mert Sahin, Naz Mina; Pekcan, Onder; Molecular Biology and GeneticsHybrid hydrogels from protein-polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein-polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These properties allow these conjugates to be used as biocompatible components in biomedical applications. Protein-polymer conjugation is a vital bioengineering strategy in many fields, such as drug delivery, tissue engineering, and cancer therapy. Protein-polymer conjugations aim to create materials with new and unique properties by combining the properties of different molecular components. There are various ways of creating protein-polymer conjugates. PEGylation is one of the most common conjugation techniques where a protein is conjugated with Polyethylene Glycol. However, some limitations of PEGylation (like polydispersity and low biodegradability) have prompted researchers to devise novel synthesis techniques like PEGylation, where synthetic polypeptides are used as the polymer component. This review will illustrate the properties of protein-polymer conjugates, their synthesis methods, and their various biomedical applications.Article Citation - WoS: 1Citation - Scopus: 1Deviation From the Balanced Time Perspective and Depression and Anxiety Symptoms: the Mediating Roles of Cognitive-Behavioral Emotion Regulation in a Cross-Cultural Model(Frontiers Media Sa, 2025) Ranjbar, Hamed Abdollahpour; Altan-Atalay, Ayse; Asgarabad, Mojtaba Habibi; Turan, Bulent; Eskin, MehmetBackground Time perspective (TP) influences how individuals perceive and classify their past, present, and future, impacting their cognition, behavior, and psychological outcomes. Deviation from the balanced time perspective (DBTP) is associated with mental health problems (e.g., depression and anxiety). Emotion regulation (ER) encompasses cognitive and behavioral processes to regulate emotions, with maladaptive strategies like rumination and withdrawal linked to depression and anxiety. Despite extensive research on TP and ER, their joint impact, particularly in the context of depression and anxiety, and cultural differences remain underexplored.Method Participants (N = 513 Iranian, N = 470 Turkish) completed self-report questionnaires on time perspective, cognitive and behavioral ER, anxiety, and depression symptoms. A moderated mediation model was assessed, incorporating the exogenous variable of DBTP, with ER strategies as mediators, and endogenous variables of depressive and anxiety symptoms. The model accounted for cultural variations in the paths as a moderator.Results Significant associations were found between DBTP, ER strategies, depression, and anxiety symptoms. Mediation analyses revealed that both cognitive and behavioral ER strategies (except for adaptive behavioral ER strategies) significantly mediated the associations between DBTP and depression and anxiety. Additionally, multigroup analyses suggested that these mediating effects were consistent across Iranian and Turkish samples, with exceptions in adaptive cognitive ER strategies.Conclusion The study highlights the crucial role of TPs and ER strategies in predicting anxiety and depression symptoms, with notable cultural nuances. Specifically, maladaptive strategies exacerbate symptoms, while adaptive strategies mitigate them primarily in Iranian contexts. Cultural subtleties are discussed in detail.Article Citation - WoS: 0Citation - Scopus: 0From 'Safe Haven' To 'zone of Precarity': Locating Istanbul Through the Perceptions and Everyday Urban Practices of Skilled Migrants(Springernature, 2025) Tuncer, Ezgi; ArchitectureThis article seeks to position Istanbul through the practices of everyday life of middle-class, skilled migrants from both the Global North and South and their perceptions of urban safety and precarity. It examines individuals' processes of migration to Turkey, revealing their initial impressions of Istanbul as a safe city of opportunities, and then analyses their everyday urban lives, highlighting hidden forms of precarity and discrimination. Through in-depth interviews with 45 women and 34 men-more than half of whom are North American and European-and participant observation in people's living environments and at various social events, I argue that Istanbul, while perceived as a 'safe haven' at first, becomes a 'zone of precarity' where most of the participants have experienced intersectional forms of precarity, latent patterns of discrimination, and insecurities that belie the common perception that skilled migrants are privileged. To substantiate this argument, this ethno-spatial study presents an analysis of qualitative data as well as an online subjective mapping of Istanbul, where perceptions of urban safety and spatial precarity are displayed through socio-spatial experiences encountered in neighbourhoods, workplaces, and public spaces.Article Citation - WoS: 0Citation - Scopus: 0Differentiating Functional Connectivity Patterns in Adhd and Autism Among the Young People: a Machine Learning Solution(Sage Publications inc, 2025) Ballı, Tuğçe; Balli, Tugce; Roeyers, Herbert; Wiersema, Jan R.; Camkerten, Sami; Ozturk, Ozan Cem; Sonuga-Barke, Edmund; Management Information SystemsObjective: ADHD and autism are complex and frequently co-occurring neurodevelopmental conditions with shared etiological and pathophysiological elements. In this paper, we attempt to differentiate these conditions among the young people in terms of intrinsic patterns of brain connectivity revealed during resting state using machine learning approaches. We had two key objectives: (a) to determine the extent to which ADHD and autism could be effectively distinguished via machine learning from one another on this basis and (b) to identify the brain networks differentially implicated in the two conditions.Method: Data from two publicly available resting-state functional magnetic resonance imaging (fMRI) resources-Autism Brain Imaging Data Exchange (ABIDE) and the ADHD-200 Consortium-were analyzed. A total of 330 participants (65 females and 265 males; mean age = 11.6 years), comprising equal subgroups of 110 participants each for ADHD, autism, and healthy controls (HC), were selected from the data sets ensuring data quality and the exclusion of comorbidities. We identified region-to-region connectivity values, which were subsequently employed as inputs to the linear discriminant analysis algorithm.Results: Machine learning models provided strong differentiation between connectivity patterns in participants with ADHD and autism-with the highest accuracy of 85%. Predominantly frontoparietal network alterations in connectivity discriminate ADHD individuals from autism and neurotypical group. Networks contributing to discrimination of autistic individuals from neurotypical group were more heterogeneous. These included language, salience, and frontoparietal networks.Conclusion: These results contribute to our understanding of the distinct neural signatures underlying ADHD and autism in terms of intrinsic patterns of brain connectivity. The high level of discriminability between ADHD and autism, highlights the potential role of brain based metrics in supporting differential diagnostics.Article Citation - WoS: 0Citation - Scopus: 0Economic Uncertainty and Climate Change Exposure(Academic Press Ltd- Elsevier Science Ltd, 2025) Öztürk Danışman, Gamze; Erdoğan, Seda; Demir, Ender; International Trade and FinanceThis paper explores how economic uncertainty affects firms' climate change exposure. We use an extensive sample from 24 countries from 2002 to 2021. Employing a novel measure of firm-level climate change exposure developed by Sautner et al. (2023b), we empirically demonstrate that prior to the Paris Agreement in 2015, economic uncertainty leads to a decrease in climate change disclosures. However, after the Paris Agreement, our findings reveal a positive association between economic uncertainty and climate change exposure. The positive disclosure effect is primarily driven by higher climate-related opportunities and regulatory exposures. Our findings are robust when we employ alternative definitions for economic uncertainty, alternative samples, additional firm-level and country-level control variables, and alternative methodologies. We find that institutional and foreign ownership positively moderates the association between economic uncertainty and climate change exposure after the Paris Agreement. Further analysis investigates the moderating impact of country-level environmental performance indicators. We present novel empirical evidence suggesting that firms operating in countries with less climate vulnerability, higher readiness, more stringent environmental policies, superior climate protection performance, and higher environmental litigation risk tend to have higher climate change exposure in uncertain times.Article Citation - WoS: 3Citation - Scopus: 3Cultural Context Shapes the Selection and Adaptiveness of Interpersonal Emotion Regulation Strategies(Amer Psychological Assoc, 2024) Pruessner, Luise; Altan-Atalay, AyseIn everyday life, we commonly experience, express, and regulate our emotions in interpersonal contexts. However, much of the existing research on utilizing others for modulating one's emotions has focused on Western, individualistic cultures, leaving a significant gap in understanding how the selection and adaptiveness of interpersonal emotion regulation (IER) strategies vary across cultural contexts. This cross-national comparison study aims to bridge this gap by examining intrinsic IER in 1,187 participants from Turkey and Germany, which are characterized by different cultural norms, values, and socialization practices regarding emotional experience and expression. All participants completed measures of intrinsic IER strategies alongside measures of adaptive outcomes, including depression, anxiety, negative affect, and positive affect. The results revealed cross-national differences between Turkish and German individuals in terms of the intrinsic IER strategies most frequently selected and their associations with depression, anxiety, negative affect, and positive affect. These findings emphasize the significance of cultural context in intrinsic IER and offer insights into the conditions under which these strategies are linked to adaptive outcomes. By recognizing the cultural nuances in how people navigate their emotions via social interactions, clinicians and researchers can develop more culturally sensitive interventions tailored to the specific needs of individuals in diverse cultural contexts.Article Citation - WoS: 0Citation - Scopus: 1Maternal Underestimations and Overestimations of Their Infants' Word Comprehension: Effects on Mothers' Verbal Input and Infants' Receptive Vocabulary(Cambridge Univ Press, 2024) Ertas, Sura; Kuntay, Aylin C.; Aktan-Erciyes, AsliInfants' language is often measured indirectly via parent reports, but mothers may underestimate or overestimate their infants' word comprehension. The current study examined estimations of mothers from diverse educational backgrounds regarding their infants' word comprehension and how these estimations are associated with their verbal input and infants' receptive vocabulary at 14 months. We compared 34 infants' looking-while- listening (LWL) performances with the mothers' Turkish Communicative Development Inventory (TCDI) reports to calculate the mothers' overestimation and underestimation. During free-play sessions, we assessed the mothers' number of words, number of clauses, lexical diversity, and linguistic complexity. We found that mothers have overestimations and underestimations regardless of their educational background. Crucially, mothers' only overestimations were positively associated with their number of words and lexical diversity. Mothers' verbal input was not related to infants' receptive vocabulary scores. The findings suggest that mothers' input might be aligned with their estimations of their infants' language capabilities, which might not reflect the infants' true performance.
