PubMed İndeksli Yayınlar Koleksiyonu
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Article Citation - WoS: 24Citation - Scopus: 30Thiols malonaldehyde status in the Turkish and total antioxidant patients with type 2 diabetes mellitus(Tohoku Univ Medical Press, 2003) Duman, Belgin Süsleyici; Öztürk, Melek; Yilmazer, Selma; Hatemi, HüsrevNon-insulin-dependent (Type 2) diabetes mellitus (NIDDM) is a risk factor for cardiovascular diseases (CVD). Oxidative stress mechanisms are often reported to be implied in type 2 diabetes mellitus. In order to determine their clinical relevance we investigated several plasma indicators in the Turkish patients with NIDDM: (1) homocysteine (Hey) and cysteine (Cys) which contribute to increase the risk of atherosclerosis during NIDDM (ii) glutathione (GSH) and cysteinylglycine (CysGly) resulting from GSH degradation catalyzed by gamma-glutamylcysteine transferase (GGT) (iii) malonaldehyde (MDA) as a marker for lipid peroxidation and (iv) total antioxidant status (TAS). Our main results were evaluated based on sex and diabetic status. In female patients plasma concentrations of MDA and Hey were significantly higher than in controls while GSH levels were significantly lower. In males a difference between control and diabetic groups was noticed only for Hey levels being also higher in patients. In the diabetic group increase in serum glucose concentration was significantly correlated with increased GGT activity. In both controls and diabetic patients GGT activity was correlated with a raised Cys concentration and a decreased GSH level. In both controls and diabetic patients there were significant positive correlations between Cys and Hey and between GSH and Hey. We concluded that GSH and MDA levels are clinical indicators for an oxidative process linked to type 2 diabetes mellitus especially in women.Article Citation - WoS: 10Citation - Scopus: 12The In-Vivo Assessment of Turkish Propolis and Its Nano Form on Testicular Damage Induced by Cisplatin(Elsevier, 2021) Seven, Pinar Tatli; Seven, Ismail; Karakus, Selcan; Mutlu, Seda Iflazoglu; Kaya, Seyma Ozer; Arkali, Gozde; Ilgar, MerveObjective: Chemotherapeutic drugs, such as cisplatin (CP), which are associated with oxidative stress and apoptosis, may adversely affect the reproductive system. This study tests whether administration of propolis and nano-propolis (NP) can alleviate oxidative stress and apoptosis in rats with testicular damage induced by CP. Methods: In this study, polymeric nanoparticles including propolis were synthesized with a green sonication method and characterized using Fourier transform-infrared spectroscopy, Brunauer-EmmettTeller, and wet scanning transmission electron microscopy techniques. In total, 56 rats were divided into the following seven groups: control, CP, propolis, NP-10, CP + propolis, CP + NP-10, and CP + NP-30. Propolis (100 mg/kg), NP-10 (10 mg/kg), and NP-30 (30 mg/kg) treatments were administered by gavage daily for 21 d, and CP (3 mg/kg) was administered intraperitoneally in a single dose. After the experiment, oxidative stress parameters, namely, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT), and apoptotic pathways including B cell leukemia/lymphoma-2 protein (Bcl-2) and Bcl-2-associated X protein (Bax) were measured in testicular tissues. Furthermore, sperm quality and weights of the testis, epididymis, right cauda epididymis, seminal vesicles and prostate were evaluated. Results: Propolis and NP (especially NP-30) were able to preserve oxidative balance (decreased MDA levels and increased GSH, CAT, and GPx activities) and activate apoptotic pathways (decreased Bax and increased Bcl-2) in the testes of CP-treated rats. Sperm motility in the control, CP, and CP + NP-30 groups were 60%, 48.75%, and 78%, respectively (P < 0.001). Especially, NP-30 application completely corrected the deterioration in sperm features induced by CP. Conclusion: The results show that propolis and NP treatments mitigated the side effects of CP on spermatogenic activity, antioxidant situation, and apoptosis in rats. (C) 2021 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by ELSEVIER B.V. All rights reserved.Article Citation - WoS: 8Citation - Scopus: 10Examining Children's Questions and Parents' Responses About Covid-19 Pandemic in Turkey(Springer, 2022) Unlutabak, Burcu; Velioglu, IlaydaCOVID-19 pandemic has had a significant impact on both adults' and children's everyday lives. Conversations about biological processes such as viruses, illness, and health have started to occur more frequently in daily interactions. Although there are many guidelines for parents about how to talk to their children about the coronavirus, only a few studies have examined what children are curious about the coronavirus and how they make sense of the changes in their everyday lives. This study addresses this need by examining children's questions and parents' responses about the COVID-19 Pandemic in the Turkish sociocultural context. Using an online survey, we asked 184 parents of 3- to 12-year-olds to report their children's questions about coronavirus and their answers to these questions. We analyzed children's questions and parents' responses using qualitative and quantitative analyses (Menendez et al., 2021). Children's questions were mainly about the nature of the virus (34%), followed by lifestyle changes (20%). Older children were more likely to ask about school/work and less likely to ask about lifestyle changes than younger children. Parents responded to children's questions by providing realistic explanations (48%) and reassurance (20%). Only 18% of children's questions were explanation-seeking why and how questions. Parents were more likely to provide explanations if children's questions were explanation-seeking. Family activities such as playing games and cooking were the most common coping strategies reported by parents (69.2%). The findings have important implications for children's learning about the coronavirus and how adults can support children's learning and help them develop coping strategies in different sociocultural contexts.Article Citation - WoS: 1Impact of Culture Shock, Acculturation Approaches, and Sociocultural Adaptation on Perceived Proficiency in Turkish and English Among International Students in Turkey(Elsevier, 2025) Tekel, Esra; Ergin-Kocaturk, Hatice; Su, Ahmet; Kocaturk, Metin; Caner, Mustafa; Karadag, EnginThe primary objective of this study was to investigate the influence of culture shock, acculturation strategies, and sociocultural adjustment on the perceived Turkish and English language proficiency of international students in Turkey. Data were collected from 3554 international students in Turkey whose native language was neither Turkish nor English, using the "Culture Shock Questionnaire", "Acculturation Measurement", and "Sociocultural Adjustment Scale". Data were analyzed using correlation and hierarchical multiple regression analyses. The results revealed that the perceived Turkish and English language proficiencies of international students in Turkey were moderate. Language proficiency, personal interests, and social participation factors of sociocultural adjustment and acculturation strategies, such as assimilation and integration, have a positive impact on perceived Turkish language proficiency. On the other hand, the interpersonal stress factor of culture shock and assimilation and integration aspects of the acculturation strategies were found to be the most critical determinants of perceived English language proficiency. Additionally, language proficiency, personal interests, and social participation factors of sociocultural adjustment and acculturation strategies, such as separation and assimilation, had positive effects, whereas the language proficiency factor of sociocultural adjustment and assimilation acculturation strategies had negative effects. The findings of this study indicate that acculturation strategies and sociocultural adjustment play a crucial role in the development of perceived target language proficiency.Article Citation - WoS: 1Citation - Scopus: 2Group Behaviour in Physical Chemical and Biological Systems(Indıan Acad Scıences, 2014) Saçlıoğlu, Cihan; Pekcan, Önder; Nanjundiah, VidyanandGroups exhibit properties that either are not perceived to exist or perhaps cannot exist at the individual level. Such 'emergent' properties depend on how individuals interact both among themselves and with their surroundings. The world of everyday objects consists of material entities. These are ultimately groups of elementary particles that organize themselves into atoms and molecules occupy space and so on. It turns out that an explanation of even the most commonplace features of this world requires relativistic quantum field theory and the fact that Planck's constant is discrete not zero. Groups of molecules in solution in particular polymers ('sols') can form viscous clusters that behave like elastic solids ('gels'). Sol-gel transitions are examples of cooperative phenomena. Their occurrence is explained by modelling the statistics of inter-unit interactions: the likelihood of either state varies sharply as a critical parameter crosses a threshold value. Group behaviour among cells or organisms is often heritable and therefore can evolve. This permits an additional typically biological explanation for it in terms of reproductive advantage whether of the individual or of the group. There is no general agreement on the appropriate explanatory framework for understanding group-level phenomena in biology.Article Citation - WoS: 2Citation - Scopus: 4Economic Uncertainty and Climate Change Exposure(Academic Press Ltd- Elsevier Science Ltd, 2025) Danisman, Gamze Ozturk; Bilyay-Erdogan, Seda; Demir, EnderThis paper explores how economic uncertainty affects firms' climate change exposure. We use an extensive sample from 24 countries from 2002 to 2021. Employing a novel measure of firm-level climate change exposure developed by Sautner et al. (2023b), we empirically demonstrate that prior to the Paris Agreement in 2015, economic uncertainty leads to a decrease in climate change disclosures. However, after the Paris Agreement, our findings reveal a positive association between economic uncertainty and climate change exposure. The positive disclosure effect is primarily driven by higher climate-related opportunities and regulatory exposures. Our findings are robust when we employ alternative definitions for economic uncertainty, alternative samples, additional firm-level and country-level control variables, and alternative methodologies. We find that institutional and foreign ownership positively moderates the association between economic uncertainty and climate change exposure after the Paris Agreement. Further analysis investigates the moderating impact of country-level environmental performance indicators. We present novel empirical evidence suggesting that firms operating in countries with less climate vulnerability, higher readiness, more stringent environmental policies, superior climate protection performance, and higher environmental litigation risk tend to have higher climate change exposure in uncertain times.Article Citation - WoS: 4Citation - Scopus: 5Kinetic Models for the Dynamical Behavior of Polyacrylamide (paam)-Kappa (kappa C) Composite Gels(Springer, 2015) Evingür, Gülşen Akın; Pekcan, ÖnderA fluorescence method was employed for studying the drying and swelling of PAAm-kappa C composite gels which were formed from acrylamide (AAm) and N N'- methylenebisacrylamide (BIS) with various kappa-carrageenan (kappa C) contents by free radical crosslinking copolymerization in water. Composite gels were prepared at 80 A degrees C with pyranine (Py) as a fluorescence probe. Scattered light I (sc) and fluorescence emission intensities I (em) were monitored during drying and swelling of these gels. The fluorescence intensity of pyranine increased and decreased as drying and swelling time are increased respectively for all gel samples. The Stern-Volmer equation combined with moving boundary and Li-Tanaka models were used to explain the behavior of I (em) during drying and swelling processes respectively. It is found that the desorption coefficient D (d) decreased as kappa C contents were increased for a given temperature during drying. However the cooperative diffusion coefficient D (s) presented exactly the opposite case. Conventional gravimetrical and volumetric experiments were also carried out during drying and swelling of PAAm-kappa C composite gels. It was observed that D (d) and D (s) values measured with the fluorescence method were found to be much larger than they were measured with the conventional methods.Article Perseverative Effort and Grit But Not Gratitude Are Protective Against the Onset of Anxiety for Cognitively At-Risk Individuals(Routledge Journals, Taylor & Francis LTD, 2025) Riskind, John H.; Altan-Atalay, Ayse; Sison, Jacqueline; Kleiman, EvanGrit and gratitude protect against depression caused by cognitive vulnerability factors like hopelessness and rumination. This study examined whether these personality strengths could buffer against a cognitive vulnerability for anxiety, the looming cognitive style (LCS). A prospective design was used with university students (N = 247; 86.2% female; aged between 18 and 60) completing online questionnaires two times 6 weeks apart that assessed LCS, grit, gratitude, and anxiety and depression. Path analyses revealed that LCS had a significant main effect and a theoretically expected interaction effect on anxiety symptoms with "grit perseverance but not with "grit consistency" or gratitude. Neither LCS, grit perseverance nor gratitude had any effects on depression symptoms, although an effect emerged for grit consistency. This study is the first to our knowledge to examine how personality strengths protect individuals against a cognitive vulnerability that is more specific to anxiety symptomatology than to depression. Along with other studies, the findings further suggest that a crucial way grit and personality strengths provide benefit is by protecting against cognitive vulnerabilities.Article Citation - WoS: 6Citation - Scopus: 7Sampling Rate-Corrected Analysis of Irregularly Sampled Time Series(Amer Physical Soc, 2022) Braun, Tobias; Fernandez, Cinthya N.; Eroglu, Deniz; Hartland, Adam; Breitenbach, Sebastian F. M.; Marwan, NorbertThe analysis of irregularly sampled time series remains a challenging task requiring methods that account for continuous and abrupt changes of sampling resolution without introducing additional biases. The edit distance is an effective metric to quantitatively compare time series segments of unequal length by computing the cost of transforming one segment into the other. We show that transformation costs generally exhibit a nontrivial relationship with local sampling rate. If the sampling resolution undergoes strong variations, this effect impedes unbiased comparison between different time episodes. We study the impact of this effect on recurrence quantification analysis, a framework that is well suited for identifying regime shifts in nonlinear time series. A constrained randomization approach is put forward to correct for the biased recurrence quantification measures. This strategy involves the generation of a type of time series and time axis surrogates which we call sampling-rate-constrained (SRC) surrogates. We demonstrate the effectiveness of the proposed approach with a synthetic example and an irregularly sampled speleothem proxy record from Niue island in the central tropical Pacific. Application of the proposed correction scheme identifies a spurious transition that is solely imposed by an abrupt shift in sampling rate and uncovers periods of reduced seasonal rainfall predictability associated with enhanced El Nino-Southern Oscillation and tropical cyclone activity.Article Citation - WoS: 8Citation - Scopus: 9Apolipoprotein B Gene Variants Are Involved in the Determination of Blood Glucose and Lipid Levels in Patients With Non-Insulin Dependent Diabetes Mellitus(Wiley, 2006) Duman, Belgin Süsleyici; Öztürk, Melek; Yilmazer, Selma; Çağatay, Penbe; Hatemi, HüsrevWe have examined the frequency of the EcoRI XbaI and MspI RFLPs of the apolipoprotein B (apo 13) gene in I 10 type 2 diabetic patients and 9 1 healthy control subjects in order to ascertain whether variation in this gene may influence the development of non-insulin dependent diabetes mellitus (type 2 diabetes). Serum lipids including total-cholesterol (T-Chol) triacylglycerol (TAG) apolipoprotein E (apo E) apolipoprotein Al (apo Al) apolipoprotein B and lipoprotein (a) (Lp(a)) were analysed. Genomic DNA was extracted and the apo B polymorphic regions amplified by the polymerase chain reaction. Regions carrying EcoRI XbaI and MspI restriction sites present in the apo B gene were amplified and digested separately by the respective enzymes. No significant difference for genotypic frequencies was observed for the EcoRI XbaI and MspI restriction sites in type 2 diabetic patients as compared to controls. Type 2 diabetic patients and controls with EcoRI +/+ and XbaI +/+ genotypes had higher apo E levels. The MspI +/+ genotype is more frequent in the patient and control groups With elevated T-Chol. Furthermore the EcoRI -/- XbaI -/- and MspI +/+ genotypes were found to be significantly more frequent in type 2 diabetic patients with higher blood glucose levels. This study identifies the apo B gene polymorphisms in modulating plasma lipid/lipoprotein and glucose levels in patients with type 2 diabetes. Copyright 0 2005 John Wiley & Sons Ltd.Article Citation - WoS: 26Citation - Scopus: 31Homology Modeling of Human Histone Deacetylase 10 and Design of Potential Selective Inhibitors(Taylor & Francis Inc, 2019) Uba, Abdullahi Ibrahim; Yelekçi, KemalHistone deacetylases (HDACs) are implicated in the pathology of various cancers, and their pharmacological blockade has proven to be promising in reversing the malignant phenotypes. However, lack of crystal structures of some of the human HDAC isoforms (e.g., HDAC10) hinders the design of the isoform-selective inhibitor. Here, the recently solved X-ray crystal structure of Danio rerio (zebrafish) HDAC10 (Protein Data Bank (PDB) ID; 5TD7, released on 24 May 2017) was retrieved from the PDB and used as a template structure to model the three-dimensional structure of human HDAC10. The overall quality of the best model (M0017) was assessed by computing its z-score-a measure of the deviation of the total energy of the structure with respect to an energy distribution derived from random conformations and by docking of known HDAC10 inhibitors to its catalytic cavity. Furthermore, to identify potential HDAC10-selective inhibitor ligand-based virtual screening was carried out against the ZINC database. The free modeled structure of HDAC10 and its complexes with quisinostat and the highest-ranked compound ZINC19749069 were submitted to molecular dynamics simulation. The comparative analysis of root-mean-squared deviation, root-mean-squared fluctuation, radius of gyration (Rg), and potential energy of these systems showed that HDAC10-ZINC19749069 complex remained the most stable over time. Thus, M0017 could be potentially used for structure-based inhibitor against HDAC10, and ZINC19749069 may provide a scaffold for further optimization. Communicated by Ramaswamy H. SarmaArticle Citation - WoS: 6Citation - Scopus: 8The Design of Potent Hiv-1 Integrase Inhibitors by a Combined Approach of Structure-Based Virtual Screening and Molecular Dynamics Simulation(Taylor & Francis Ltd, 2018) Samorlu, Augustine S.; Yelekçi, Kemal; Uba, Abdullahi IbrahimBu araştırmanın amacı, AIDS olarak bilinen insan bağışıklık sistemine etki eden, duraksamayan ve depresif bir hastalığa neden olan HIV-1'in tedavisi için potansiyel inhibitörleri elde etmektir. HIV-1 integraz inhibitörleri, HIV-1 enfeksiyonunun tedavisinde çok önemlidir. İntegraz enziminin (IN) inhibe edilmesi HIV-1 virüsünün çoğalma işleminin sonlandırılmasına neden olur. Böylece yaşam döngüsüne son verir. Bu inhibitörleri elde etmek için bilgisayar destekli in silico yaklaşım kullanılmıştır. Temelde, Otava Kimya Kütüphanesi tarandı ve inhibitör tasarımında kullanılan sistematik yaklaşımlar uygulandı, böylece dört güçlü integraz inhibitörü bulundu. İnhibitörlerin enzime bağlanma değerleri PyRx ve AutoDock 4.2 doklama programları kullanılarak gerçekleştirildi. Çalışmada bir kimyasalın güçlü bir inhibitör olabilmesi için hesaplanan serbest bağ enerjisi = -8.00 kcal / mol veya daha az olması ve integrazın aktif bölgesinde bulunan 3 önemli amino asidinden herhangi biri ile de etkileşimde bulunması kriterine uyulmuştur. Discovery Studio Visualizer, inhibitörlerin yapısını çizmekte, inhibitörü komplekslerinin resimlerini üretmekte, enzim ve inhibitör arasındaki etkileşimin türünü belirlememizi sağlayan 2D ve 3D yapıları görüntülemek için kullanıldı. Elde edilen dört güçlü inhibitörden, kendimizin tasarladığı moleküllerden (Ki= 652.83 nanomolar bir ve bağlanma serbest enerjisi -8.44kcal / mol), kalan üç inhibitörde, Otava Kimya Kütüphanesi'nde tarandı ve Otava koduyla parantez içerisinde listelenmiştir. Bunların inhibisyon sabiti ve bağlanma enerjileri sırasıyla; 107320240, Ki=131.7nm, -9.39kcal/ mol; 109750115, Ki= 44.19nm, -10.03kcal / mol; 111150115 Ki = 395.19nm, -8.74kcal / mol olarak bulunmuştur.Letter Citation - Scopus: 1The fragile point of cardiac rehabilitation: Exercise compliance (The effects of phase II cardiac rehabilitation programme on patients undergone coronary bypass surgery) (multiple letters)(2005) Kaşikcioğlu, E.; Çiftci, Ç.[No abstract available]Data Paper Citation - WoS: 38Citation - Scopus: 45Social and Moral Psychology of Covid-19 Across 69 Countries(Nature Portfolio, 2023) Azevedo, Flavio; Pavlovic, Tomislav; Rego, Gabriel G.; Ay, F. Ceren; Gjoneska, Biljana; Etienne, Tom W.; Ross, Robert M.The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.Article Citation - WoS: 4Multimodal Language in Child-Directed Versus Adult-Directed Speech(Sage Publications Ltd, 2023) Kandemir, Songul; Ozer, Demet; Aktan-Erciyes, AsliSpeakers design their multimodal communication according to the needs and knowledge of their interlocutors, phenomenon known as audience design. We use more sophisticated language (e.g., longer sentences with complex grammatical forms) when communicating with adults compared with children. This study investigates how speech and co-speech gestures change in adult-directed speech (ADS) versus child-directed speech (CDS) for three different tasks. Overall, 66 adult participants (M-age = 21.05, 60 female) completed three different tasks (story-reading, storytelling and address description) and they were instructed to pretend to communicate with a child (CDS) or an adult (ADS). We hypothesised that participants would use more complex language, more beat gestures, and less iconic gestures in the ADS compared with the CDS. Results showed that, for CDS, participants used more iconic gestures in the story-reading task and storytelling task compared with ADS. However, participants used more beat gestures in the storytelling task for ADS than CDS. In addition, language complexity did not differ across conditions. Our findings indicate that how speakers employ different types of gestures (iconic vs beat) according to the addressee's needs and across different tasks. Speakers might prefer to use more iconic gestures with children than adults. Results are discussed according to audience design theory.Article Citation - WoS: 3Citation - Scopus: 3Transmembrane Helix 6 Observed at the Interface of Beta(2)ar Homodimers in Blind Docking Studies(Taylor & Francis Inc, 2015) Koroğlu, Ayça; Akten, Ebru DemetPeptide- and protein-protein dockings were carried out on beta(2)-adrenergic receptor (beta(2)AR) to confirm the presence of transmembrane helix 6 (TM6) at the interface region between two beta(2)AR monomers thereby its possible role in dimerization as suggested in numerous experimental and computational studies. Initially a portion of TM6 was modeled as a peptide consisting of 23 residues and blindly docked to beta(2)AR monomer using a rigid body approach. Interestingly all highest score conformations preferred to be near TM5 and TM6 regions of the receptor. Furthermore longer peptides generated from a whole TM region were blindly docked to beta(2)AR using the same rigid body approach. This yielded a total of seven docked peptides each derived from one TM helix. Most interestingly for each peptide TM6 was among the most preferred binding site region in the receptor. Besides the peptide dockings two beta(2)AR monomers were blindly docked to each other using a full rigid-body search of docking orientations which yielded a total of 16000 dimer conformations. Each dimer was then filtered according to a fitness value based on the membrane topology. Among 149 complexes that met the topology requirements 102 conformers were composed of two monomers oriented in opposite directions whereas in the remaining 47 the monomers were arranged in parallel. Lastly all 149 conformers were clustered based on a root mean-squared distance value of 6 angstrom. In agreement with the peptide results the clustering yielded the largest population of conformers with the highest Z-score value having TM6 at the interface region.Article Does Attention Sharing Support Attention Focusing? Investigating the Link Between Infants' Sustained Attention and Joint Attention With Caregivers(Elsevier Science inc, 2025) Uzundag, Berna A.Sustained attention in infancy is a known predictor of executive functions, self-regulation, and language. This study investigated the relationship between 9-to 16-month-old infants' sustained attention and joint attention in mother-infant dyads. Data were collected from 98 infants (M(SD) = 11.8(1.3) months) and their mothers. Results showed that joint attention during mother-infant play significantly predicted sustained attention during solo play, after accounting for infant age and socioeconomic status. These cross-sectional findings suggest that joint attention may play a role in supporting sustained attention, though the directionality of this relationship warrants further longitudinal investigation.Article Citation - WoS: 11Citation - Scopus: 8Novel 1,2,4-Triazoles Derived From Ibuprofen: Synthesis and in Vitro Evaluation of Their Mpges-1 Inhibitory and Antiproliferative Activity(Springer, 2022) Bulbul, Bahadir; Ding, Kai; Zhan, Chang-Guo; Ciftci, Gamze; Yelekci, Kemal; Gurboga, Merve; Ozakpinar, Ozlem BingolSome novel triazole-bearing ketone and oxime derivatives were synthesized from Ibuprofen. In vitro cytotoxic activities of all synthesized molecules against five cancer lines (human breast cancer MCF-7, human lung cancer A549, human prostate cancer PC-3, human cervix cancer HeLa, and human chronic myelogenous leukemia K562 cell lines) were evaluated by MTT assay. In addition, mouse embryonic fibroblast cells (NIH/3T3) were also evaluated to determine the selectivity. Compounds 18, 36, and 45 were found to be the most cytotoxic, and their IC50 values were in the range of 17.46-68.76 mu M, against the tested cancer cells. According to the results, compounds 7 and 13 demonstrated good anti-inflammatory activity against the microsomal enzyme prostaglandin E2 synthase-1 (mPGES-1) enzyme at IC50 values of 13.6 and 4.95 mu M. The low cytotoxicity and non-mutagenity of these compounds were found interesting. Also, these compounds significantly prevented tube formation in angiogenesis studies. In conclusion, the anti-inflammatory and angiogenesis inhibitory activities of these compounds without toxicity suggested that they may be promising agents in anti-inflammatory treatment and they may be supportive agents for the cancer treatment. [GRAPHICS] .Article Investigation and Development of Novel Synthetic Approaches for Synthesis of Euxanthone and Derived Dyes(Royal Soc Chemistry, 2024) Cetin, M. MustafaThe historical dye Indian yellow, derived from euxanthic acid formed from 1,7-dihydroxyxanthone (euxanthone) and methyl (tri-O-acetyl-alpha-d-glucopyranosyl bromide) uronate, has significantly influenced the art world due to its vibrant color and unique production process. Studying Indian yellow is important for its historical relevance and impact on various art forms, as well as the challenges in its synthetic production. Herein, this work investigates the synthesis of the two main components, a novel method for obtaining euxanthone, and attempts to produce euxanthic acid and Indian yellow. All key intermediates and desired compounds have successfully been synthesized with good to high isolated yields, and characterized using different analytical and spectroscopic techniques. A proposed mechanism for euxanthone synthesis via 2,6,2 ',5 '-tetramethoxybenzophenone formation is also offered. During this process, 2,7-dihydroxyxanthone has also been synthesized, revealing an equilibration reaction that produced three isomeric tetramethoxybenzophenones, confirmed by both GC/MS and NMR. Following the synthesis of euxanthone and clarification of the equilibration, the production of Indian yellow via euxanthic acid formation has further been explored.Article Citation - WoS: 19Citation - Scopus: 23Does normoxemic cardiopulmonary bypass prevent myocardial reoxygenation injury in cyanotic children?(W.B. Saunders Co Ltd, 2002) Bulutcu, Füsun S.; Bayındır, Osman; Polat, Bülent; Yalçın, Yalim; Özbek, Uğur; Cakali, EmineObjective: To evaluate whether the deleterious effect of cardiopulmonary bypass (CPB) can be prevented by controlling PaO2 in cyanotic children. Design: Prospective randomized clinical study. Setting: Single university hospital. Participants: Pediatric patients undergoing cardiac surgery for repair of congenital heart disease (n = 24). Interventions: Patients were randomly allocated into 3 groups. Patients in the acyanotic group (group I n = 10) had CPB initiated at a fraction of inspired oxygen (F1O2) of 1.0 (PO2 300 to 350 mmHg). Cyanotic patients were subdivided as follows: Group 11 (n = 7) had CPB initiated at an F1O2 of 1.0 and group III (n = 7) had CPB initiated at an F1O2 of 0.21 (PO2 90 to 110 mmHg). A biopsy specimen of right atrial tissue was removed during venous cannulation and another sample was removed after CPB before aortic cross-clamping. The tissue was incubated in 4 mmol/L of t-butylhydroperoxide and the malondialdehyde (MDA) level was measured to determine the antioxidant reserve capacity. Blood samples for cytokine levels tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 response to CPB were collected after induction of anesthesia and at the end of CPB before prolamine administration. Measurements and Main Results: After initiation of CPB MDA level rose markedly in the cyanotic groups compared with the acyanotic group (210 +/- 118% v 52 +/- 34% p < 0.05) which indicated the depletion of antioxidants. After initiation of CPB TNF-&alpha
