PubMed İndeksli Yayınlar Koleksiyonu
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Browsing PubMed İndeksli Yayınlar Koleksiyonu by Publication Category "Diğer"
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Correction Citation - WoS: 0Citation - Scopus: 0The Acquisition and Use of Relative Clauses in Turkish-Learning Children's Conversational Interactions: a Cross-Linguistic Approach (vol 46, Pg 1142, 2019)(Cambridge Univ Press, 2022) Uzundag, Berna A.; Arslan Uzundağ, Berna; Kuntay, Aylin C.[Abstract Not Available]Other Antibiyotikli kemik çimentosunun 0 ve 15. günlerde mekanik dayanımı: Surgical Simplex P kemik çimentosu ve teikoplanin ile biyomekanik çalışma(Türk Ortopedi ve Travmatoloji Derneği, 2002) Göğüş, Abdullah; Akman, Şenol; Göksan, Bora S.; Bozdağ, ErgünAmaç: Mekanik dayanım açısından 40 gr belirli bir kemik çimentosuna katılabilecek belirli bir antibiyotiğin maksimum dozu "0. gün" ve antibiyotik salınımı sonrası "15. gün" için araştırıldı. Çalışma planı: 40 g Surgical Simplex P kemik çimentosuna 0, 400, 800,1200,1600, 2000, 3200 ve 4000 mg teikoplanin katılarak sekiz deney grubu oluşturuldu. Kompresyon ve dört nokta eğme mekanik dayanım testleri için üçüncü kuşak sement hazırlama ve uygulama koşullarında örnekler elde edildi. Her bir konsantrasyon için "0. gün" ve "15. gün" için 10'ar örnek oluşturuldu. Örneklerin mekanik dayanım testleri ASTM ve ISO standartlarına göre "0. gün" ve 37∘ C su banyosunda antibiyotik salınımı sonrası "15. gün"de yapıldı. Değişik antibiyotik konsantrasyonları 0 mg kontrol grubu ile, ayrıca aynı antibiyotik konsantrasyonlarının 0. gün ve 15. gün mekanik test sonuçları karşılaştırıldı. Sonuçlar: Kompresyon testlerinde "0. gün" grubu içinde anlamlı farklılık bulunmadı; "15. gün" grubunda ise 800 mg'den itibaren anlamlı dayanım azalması saptandı. Her iki grupta tüm konsantrasyonlarda elde edilen mekanik dayanım değerleri ASTM alt limiti olan 70 MPa'nın üzerindeydi. Dört nokta eğme testinde "0. gün" grubunda 1200 mg'den itibaren, "15. gün" grubunda ise 400 mg'den itibaren anlamlı dayanım azalması saptandı. "15. gün" grubundan 4000 mg ISO'nun alt limiti olan 50 MPa'nın altında kalırken, 3200 ve 2000 mg gruplarında 50 MPa'ya çok yakın sonuçlar elde edildi. Çıkarımlar: Deney sonuçları, üçüncü kuşak çimento hazırlama ve uygulama koşullarında, 40 gr Surgical Simplex P kemik çimentosuna güvenle katılabilecek en yüksek teikoplanin dozunun 1600 mg olduğunu gösterdi.Erratum Citation - Scopus: 1Author Correction: National Identity Predicts Public Health Support During a Global Pandemic (nature Communications, (2022), 13, 1, (517), 10.1038/S41467-021-27668-9)(Nature Research, 2022) Van, Bavel, J.J.; Cichocka, A.; Capraro, V.; Sjåstad, H.; Nezlek, J.B.; Pavlovi?, T.; Alfano, M.In this article the author name ‘Agustin Ibanez’ was incorrectly written as ‘Augustin Ibanez’. The original article has been corrected. © The Author(s) 2022.Editorial Citation - WoS: 8Citation - Scopus: 8Beyond Sightseeing: How Can Tourism Affect Public/Global Health in Modern Society?(Int Soc Global Health, 2022) Wen, Jun; Kozak, Metin; Kozak, Metin; Jiang, Yangyang[Abstract Not Available]Review Citation - WoS: 53Citation - Scopus: 58Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications(Wiley, 2023) Istıf, Emın; Bathaei, Mohammad Javad; Istif, Emin; Karimi, Seyed Nasir Hosseini; Beker, LeventRecent materials, microfabrication, and biotechnology improvements have introduced numerous exciting bioelectronic devices based on piezoelectric materials. There is an intriguing evolution from conventional unrecyclable materials to biodegradable, green, and biocompatible functional materials. As a fundamental electromechanical coupling material in numerous applications, novel piezoelectric materials with a feature of degradability and desired electrical and mechanical properties are being developed for future wearable and implantable bioelectronics. These bioelectronics can be easily integrated with biological systems for applications, including sensing physiological signals, diagnosing medical problems, opening the blood-brain barrier, and stimulating healing or tissue growth. Therefore, the generation of piezoelectricity from natural and synthetic bioresorbable polymers has drawn great attention in the research field. Herein, the significant and recent advancements in biodegradable piezoelectric materials, including natural and synthetic polymers, their principles, advanced applications, and challenges for medical uses, are reviewed thoroughly. The degradation methods of these piezoelectric materials through in vitro and in vivo studies are also investigated. These improvements in biodegradable piezoelectric materials and microsystems could enable new applications in the biomedical field. In the end, potential research opportunities regarding the practical applications are pointed out that might be significant for new materials research.Review Citation - Scopus: 1Cervical Spine Injuries in Children(2004) Hamzaoglu, A.; Mirzanli, C.Cervical spine injuries in children and adolescents are rare. Common mechanisms include motor vehicle accidents, sports injuries, fall from height, and gunshot injuries. Cervical spine injuries are classified by Allen and Ferguson according to the period they occur, as infantile, early juvenile, and late juvenile. Anatomically, two main types are defined as occipitoatlantal (upper cervical) and subaxial injuries. The purpose of this paper is to review cervical spine injuries in children and adolescents with respect to epidemiology, injury mechanisms, diagnosis, clinical and radiologic aspects, and treatment in the light of the current literature.Review Citation - WoS: 17Citation - Scopus: 17Cognitive Styles and Religion(Elsevier B.V., 2021) Yılmaz, Onurcan; Yılmaz, OnurcanI discuss recent research suggesting that individual differences in cognitive style give rise to and explain religious and related supernatural and paranormal beliefs. To do so, I illustrate intuitive cognitive biases (e.g., anthropomorphism) underlying these beliefs and then review the accumulated evidence indicating that non-believers are more open-minded, reflective, and less susceptible to holding epistemically suspect beliefs (e.g., conspiracy theories) on average than those who believe in supernatural events or paranormal experiences such as astrology or magic. However, seeing religion as a search for truth positively predicts reasoning performance. Although these findings are robust across diverse measures, evidence for a causal relationship remains mixed. Stronger and more precise manipulations and cross-cultural investigations are needed.Erratum Citation - Scopus: 1Corrigendum To “discovery of New Azoles With Potent Activity Against Candida Spp. and Candida Albicans Biofilms Through Virtual Screening” [eur. J. Med. Chem. 179 (2019) 634–648](s0223523419306105)(10.1016/J.ejmech.2019.06.083)](Elsevier Masson SAS, 2020) Sari, S.; Kart, D.; Öztürk, N.; Kaynak, F.B.; Gencel, M.; Taşkor, G.; Karakurt, A.The authors regret to inform that there has been a mistake in the affiliation of one of the co-authors, Şebnem Eşsiz. The author's affiliation in the original article is “Hacettepe University, Faculty of Engineering, Department of Physical Engineering, 06800, Ankara, Turkey”. The correct affiliation for Şebnem Eşsiz should be “Kadir Has University, Faculty of Engineering and Natural Sciences, Department of Bioinformatics and Genetics, 34083, Istanbul, Turkey". I would be thankful if you could correct this typographical error. The authors would like to apologise for any inconvenience caused. © 2020 Elsevier Masson SASLetter Citation - WoS: 2Citation - Scopus: 2Decrease in Staphylococcus Aureus Surgical Site Infections Following Cardiovascular Surgery(W.B. Saunders Co Ltd, 2005) Coşkun, Diler; Aytaç, Jale[Abstract Not Available]Letter Citation - WoS: 14Citation - Scopus: 18Decrease in Staphylococcus aureus surgical-site infection rates after orthopaedic surgery after intranasal mupirocin ointment(W B Saunders Co Ltd, 2004) Coskun, D; Aytac, J[Abstract Not Available]Correction Citation - WoS: 0Citation - Scopus: 15Discovery of New Azoles With Potent Activity Against Candida Spp. and Candida Albicans Biofilms Through Virtual Screening(Elsevier, 2020) Karakurt, Arzu; Eşsiz, Şebnem; Kart, Didem; Öztürk, Naile; Kaynak, F. Betül; Gencel, Melis; Taşkor, Gülce; Karakurt, Arzu; Saraç, Selma; Eşsiz, Şebnem; Dalkara, SevimSystemic candidiasis is a rampant bloodstream infection ofCandidaspp. andC. albicansis the majorpathogen isolated from infected humans. Azoles, the most common class of antifungals which sufferfrom increasing resistance, and especially intrinsically resistant non-albicans Candida(NAC) species, actby inhibiting fungal lanosterol 14a-demethylase (CYP51). In this study we identified a number of azolecompounds in 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol/ethanone oxime ester structurethrough virtual screening using consensus scoring approach, synthesized and tested them for theirantifungal properties. We reached several hits with potent activity against azole-susceptible and azole-resistantCandidaspp. as well as biofilms ofC. albicans.5i's minimum inhibitor concentration (MIC) was0.125mg/ml againstC. albicans, 0.5mg/ml againstC. kruseiand 1mg/ml against azole-resistantC. tropicalisisolate. Considering the MIC values offluconazole against these fungi (0.5, 32 and 512mg/ml, respec-tively),5iemerged as a highly potent derivative. The minimum biofilm inhibitor concentration (MBIC) of5c,5j, and5pwere 0.5mg/ml (and5iwas 2mg/ml) againstC. albicansbiofilms, lower than that ofamphotericin B (4mg/ml), afirst-line antifungal with antibiofilm activity. In addition, the active com-pounds showed neglectable toxicity to human monocytic cell line. We further analyzed the dockingposes of the active compounds inC. albicansCYP51 (CACYP51) homology model catalytic site andidentified molecular interactions in agreement with those of known azoles with fungal CYP51s andmutagenesis studies of CACYP51. We observed the stability of CACYP51 in complex with5iin moleculardynamics simulations.©2019 Elsevier Masson SAS. All rights reserved.1. IntroductionSystemic candidiasis is a major public health issue, especiallywith immune-suppressed cases reaching high mortality rates. Themembers of the genusCandidaare the most frequently recoveredfrom human fungal infection andCandida albicans, so far, is theleading pathogen identified in nosocomial candidiasis [1]. Inaddition to increasing drug-resistant strains ofC. albicans, emer-gence of non-albicans Candidaspp. (NAC) complicate the treatmentof mycoses [2].C. tropicalisis among the NACs that show reducedsusceptibility tofirst-line antifungals reportedly leading to break-through fungemia among high-risk patients [3,4]. Also,C. kruseiisknown to be intrinsically resistant to a number of azoles includingfluconazole [5]. One of the several mechanisms of therapy-resistance is formation of biofilms, which are complex microor-ganism colonies enclosed in an exopolysaccharide matrix on bioticand non-biotic surfaces. Persistent biofilms make fungi much lesssusceptible to antifungal drugs compared to their planktonic formsfor a number of reasons [6e8]. Therefore it is essential to design*Corresponding author. Hacettepe University Faculty of Pharmacy, Departmentof Pharmaceutical Chemistry, 06100, Sihhiye, Ankara, Turkey.E-mail addresses:suat.sari@hacettepe.edu.tr,suat1039@gmail.com(S. Sari).Contents lists available atScienceDirectEuropean Journal of Medicinal Chemistryjournal homepage:http://www.elsevier.com/locate/ejmechhttps://doi.org/10.1016/j.ejmech.2019.06.0830223-5234/©2019 Elsevier Masson SAS. All rights reserved.European Journal of Medicinal Chemistry 179 (2019) 634e648Review Citation - WoS: 55Citation - Scopus: 70Drug Design for Cns Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3d-Qsar and Virtual Screening Methodologies(Frontiers Media Sa, 2016) Nikolic, Katarina; Yelekçi, Kemal; Mavridis, Lazaros; Djikic, Teodora; Vucicevic, Jelica; Agbaba, Danica; Yelekçi, Kemal; Mitchell, John B. O.The diverse cerebral mechanisms implicated in Central Nervous System (CNS) diseases together with the heterogeneous and overlapping nature of phenotypes indicated that multitarget strategies may be appropriate for the improved treatment of complex brain diseases. Understanding how the neurotransmitter systems interact is also important in optimizing therapeutic strategies. Pharmacological intervention on one target will often influence another one, such as the well-established serotonin-dopamine interaction or the dopamine-glutamate interaction. It is now accepted that drug action can involve plural targets and that polypharmacological interaction with multiple targets, to address disease in more subtle and effective ways, is a key concept for development of novel drug candidates against complex CNS diseases. A multi-target therapeutic strategy for Alzheimer's disease resulted in the development of very effective Multi-Target Designed Ligands (MTDL) that act on both the cholinergic and monoaminergic systems, and also retard the progression of neurodegeneration by inhibiting amyloid aggregation. Many compounds already in databases have been investigated as ligands for multiple targets in drug discovery programs. A probabilistic method, the ParzenRosenblatt Window approach, was used to build a "predictor" model using data collected from the ChEMBL database. The model can be used to predict both the primary pharmaceutical target and off-targets of a compound based on its structure. Several multi-target ligands were selected for further study, as compounds with possible additional beneficial pharmacological activities. Based on all these findings, it is concluded that multipotent ligands targeting AChE/MAO-A/MAO-B and also D-1-R/D-2-R/5-HT2A-R/H-3-R are promising novel drug candidates with improved efficacy and beneficial neuroleptic and procognitive activities in treatment of Alzheimer's and related neurodegenerative diseases. Structural information for drug targets permits docking and virtual screening and exploration of the molecular determinants of binding, hence facilitating the design of multi-targeted drugs. The crystal structures and models of enzymes of the monoaminergic and cholinergic systems have been used to investigate the structural origins of target selectivity and to identify molecular determinants, in order to design MTDLs.Letter Citation - Scopus: 0The Effects of Phase Ii Cardiac Rehabilitation Programme on Patients Undergone Coronary Bypass Surgery (multipple Letters)(Anadolu Kardiyoloji Dergisi, 2005) Uzun, M.; Çiftçi, Ç.[No abstract available]Review Citation - WoS: 0Citation - Scopus: 0Enhancing portfolio management using artificial intelligence: literature review(Frontiers Media Sa, 2024) Sutiene, Kristina; Schwendner, Peter; Sipos, Ciprian; Lorenzo, Luis; Mirchev, Miroslav; Lameski, Petre; Cerneviciene, JurgitaBuilding an investment portfolio is a problem that numerous researchers have addressed for many years. The key goal has always been to balance risk and reward by optimally allocating assets such as stocks, bonds, and cash. In general, the portfolio management process is based on three steps: planning, execution, and feedback, each of which has its objectives and methods to be employed. Starting from Markowitz's mean-variance portfolio theory, different frameworks have been widely accepted, which considerably renewed how asset allocation is being solved. Recent advances in artificial intelligence provide methodological and technological capabilities to solve highly complex problems, and investment portfolio is no exception. For this reason, the paper reviews the current state-of-the-art approaches by answering the core question of how artificial intelligence is transforming portfolio management steps. Moreover, as the use of artificial intelligence in finance is challenged by transparency, fairness and explainability requirements, the case study of post-hoc explanations for asset allocation is demonstrated. Finally, we discuss recent regulatory developments in the European investment business and highlight specific aspects of this business where explainable artificial intelligence could advance transparency of the investment process.Erratum Citation - Scopus: 1Erratum: Publisher Correction: Situational Factors Shape Moral Judgements in the Trolley Dilemma in Eastern, Southern and Western Countries in a Culturally Diverse Sample (nature Human Behaviour (2022) 6 6 (880-895))(NLM (Medline), 2022) Bago, B.; Kovacs, M.; Protzko, J.; Nagy, T.; Kekecs, Z.; Palfi, B.; Adamkovic, M.[No abstract available]Letter Citation - WoS: 2Citation - Scopus: 3Evaluation of surgical-site infections following cardiovascular surgery(SLACK INC, 2004) Coşkun, Diler; Aytaç, Jale; Deveci, Seda; Sonmez, Emine[Abstract Not Available]Letter Citation - Scopus: 1The fragile point of cardiac rehabilitation: Exercise compliance (The effects of phase II cardiac rehabilitation programme on patients undergone coronary bypass surgery) (multiple letters)(2005) Kaşikcioğlu, E.; Çiftci, Ç.[No abstract available]Editorial Citation - WoS: 5Citation - Scopus: 7Gastrointestinal: Epiploic appendagitis(Blackwell Publishing Asia, 2005) Kantarcı, Mecit; Duran, Celal; Şırvancı, Mustafa[Abstract Not Available]Editorial Citation - WoS: 20In Situ Split Costal Cartilage Graft Harvesting Through a Small Incision Using a Gouge(Lippincott Williams & Wilkins, 2000) Ağaoğlu, Galip; Erol, O. OnurA costal cartilage graft is one of the most useful materials in reconstructive plastic surgery. In this article a technique of in situ split costal cartilage graft harvesting through a small incision (2 to 3 cm) using a gouge is described. The technique used has many advantages: it is a simple technique is easy to learn and can be performed quickly through a small incision. By avoiding complete costal cartilage graft harvesting the associated potential complications such as pleural perforation chest wall deformities long-lasting postoperative pain and incisional scar length are reduced. This technique will be useful in selected cases for which a complete block of costal cartilage graft is not needed.Editorial Citation - WoS: 0Citation - Scopus: 0Intravertebral Vacuum Phenomenon That Developed During Transpedicular Biopsy(W.B. Saunders Co Ltd, 2002) Şırvancı, Mustafa; Duran, Cihan; Aydıner, Omer[Abstract Not Available]
