Şahin, Hatice Bahar

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https://hdl.handle.net/20.500.12469/6987
Name Variants
Şahin, Hatice Bahar
H.,Şahin
H. B. Şahin
Hatice Bahar, Şahin
Sahin, Hatice Bahar
H.,Sahin
H. B. Sahin
Hatice Bahar, Sahin
Şahin, H. Bahar
Job Title
Dr. Öğr. Üyesi
Email Address
Hbahar.sahı[email protected]
Main Affiliation
Molecular Biology and Genetics
Status
Former Staff
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Sustainable Development Goals

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LIFE ON LAND
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PEACE, JUSTICE AND STRONG INSTITUTIONS
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14

LIFE BELOW WATER
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CLEAN WATER AND SANITATION
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GOOD HEALTH AND WELL-BEING
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QUALITY EDUCATION
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REDUCED INEQUALITIES
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AFFORDABLE AND CLEAN ENERGY
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INDUSTRY, INNOVATION AND INFRASTRUCTURE
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RESPONSIBLE CONSUMPTION AND PRODUCTION
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DECENT WORK AND ECONOMIC GROWTH
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Scholarly Output

4

Articles

4

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23/684

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WoS Citation Count

57

Scopus Citation Count

82

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3

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3

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WoS Citations per Publication

14.25

Scopus Citations per Publication

20.50

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Disease Models & Mechanisms1
Fly1
Journal of Cell Science1
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Now showing 1 - 4 of 4
  • Thumbnail Image
    Article
    Citation - Scopus: 23
    The Drosophila Fragile X Mental Retardation Protein Participates in the Pirna Pathway
    (Company of Biologists Ltd, 2015) Bozzetti, Maria Pia; Specchia, Valeria; Cattenoz, Pierre B.; Laneve, Pietro; Geusa, Annamaria; Şahin, H. Bahar; Di Tommaso, Silvia D.; Friscini, Antonella; Massari, Serafina; Diebold, Celine; Giangrande, Angela
    RNA metabolism controls multiple biological processes and a specific class of small RNAs called piRNAs act as genome guardians by silencing the expression of transposons and repetitive sequences in the gonads. Defects in the piRNA pathway affect genome integrity and fertility. The possible implications in physiopathological mechanisms of human diseases have made the piRNA pathway the object of intense investigation and recent work suggests that there is a role for this pathway in somatic processes including synaptic plasticity. The RNA-binding fragile X mental retardation protein (FMRP also known as FMR1) controls translation and its loss triggers the most frequent syndromic form of mental retardation as well as gonadal defects in humans. Here we demonstrate for the first time that germline as well as somatic expression of Drosophila Fmr1 (denoted dFmr1) the Drosophila ortholog of FMRP are necessary in a pathway mediated by piRNAs. Moreover dFmr1 interacts genetically and biochemically with Aubergine an Argonaute protein and a key player in this pathway. Our data provide novel perspectives for understanding the phenotypes observed in Fragile X patients and support the view that piRNAs might be at work in the nervous system. © 2015.
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    Article
    Citation - WoS: 47
    Citation - Scopus: 49
    New Insights Into the Regulatory Function of Cyfip1 in the Context of Wave- and Fmrp-Containing Complexes
    (Company of Biologists Ltd, 2017) Abekhoukh, Sabiha; Şahin, H. Bahar; Grossi, Mauro; Zongaro, Samantha; Maurin, Thomas; Madrigal, Irene; Kazue-Sugioka, Daniele; Raas-Rothschild, Annick; Doulazmi, Mohamed; Carrera, Pilar; Stachon, Andrea; Scherer, Steven; Do Nascimento, Maria Rita Drula; Trembleau, Alain; Arroyo, Ignacio; Szatmari, Peter; Smith, Isabel M.; Mila, Montserrat; Smith, Adam C.; Giangrande, Angela; Caille, Isabelle; Bardoni, Barbara
    Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID) autism schizophrenia and epilepsy. It is a member of a family of proteins that is highly conserved during evolution sharing high homology with its Drosophila homolog dCYFIP. CYFIP1 interacts with the Fragile X mental retardation protein (FMRP encoded by the FMR1 gene) whose absence causes Fragile X syndrome and with the translation initiation factor eIF4E. It is a member of theWAVE regulatory complex (WRC) thus representing a link between translational regulation and the actin cytoskeleton. Here we present data showing a correlation between mRNA levels of CYFIP1 and other members of the WRC. This suggests a tight regulation of the levels of the WRC members not only by post-translational mechanisms as previously hypothesized. Moreover we studied the impact of loss of function of both CYFIP1 and FMRP on neuronal growth and differentiation in two animal models -fly and mouse. We show that these two proteins antagonize each other's function not only during neuromuscular junction growth in the fly but also during new neuronal differentiation in the olfactory bulb of adult mice. Mechanistically FMRP and CYFIP1 modulate mTor signaling in an antagonistic manner likely via independent pathways supporting the results obtained in mouse as well as in fly at the morphological level. Collectively our results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction.
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    Article
    Citation - WoS: 3
    Citation - Scopus: 2
    Salt Inducible Kinases as Novel Notch Interactors in the Developing Drosophilaretina
    (Public Library Science, 2020) Şahin, H. Bahar; Sayın, Sercan; Holder, Maxine; Bugra, Kuyaş; Çelik, Arzu
    Developmental processes require strict regulation of proliferation, differentiation and patterning for the generation of final organ size. Aberrations in these fundamental events are critically important in tumorigenesis and cancer progression.Salt inducible kinases(Siks) are evolutionarily conserved genes involved in diverse biological processes, including salt sensing, metabolism, muscle, cartilage and bone formation, but their role in development remains largely unknown. Recent findings implicate Siks in mitotic control, and in both tumor suppression and progression. Using a tumor model in theDrosophilaeye, we show that perturbation of Sik function exacerbates tumor-like tissue overgrowth and metastasis. Furthermore, we show that bothDrosophila Sikgenes,Sik2andSik3, function in eye development processes. We propose that an important target of Siks may be the Notch signaling pathway, as we demonstrate genetic interaction between Siks and Notch pathway members. Finally, we investigate Sik expression in the developing retina and show that Sik2 is expressed in all photoreceptors, basal to cell junctions, while Sik3 appears to be expressed specifically in R3/R4 cells in the developing eye. Combined, our data suggest thatSikgenes are important for eye tissue specification and growth, and that their dysregulation may contribute to tumor formation.
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    Article
    Citation - WoS: 7
    Citation - Scopus: 8
    Novel Mutants of the Aubergine Gene
    (Taylor & Francis Inc, 2016) Şahin, H. Bahar; Karataş, Ömer Faruk; Specchia, Valeria; Di Tommaso, Silvia D.; Diebold, Celine; Bozzetti, Maria Pia; Giangrande, Angela
    Aubergine is an RNA-binding protein of the Piwi clade functioning in germline in the piRNA pathway that silences transposons and repetitive sequences. Several mutations of this gene exist but they mostly result in truncated proteins or correspond to mutations that also affect neighboring genes. We have generated complete aubergine knock-out mutants that do not disrupt the neighboring genes. These novel mutants are characterized by PCR and sequencing. Their nature is confirmed by female sterility and by the presence of crystals in testes common to the aubergine loss of function mutations. These mutants provide novel and more appropriate tools for the study of the piRNA pathway that controls genome stability.