Arpağ, Göker

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ARPAĞ, GÖKER
Göker Arpağ
A., Goker
Goker, Arpag
GÖKER ARPAĞ
Arpag,G.
Arpağ, GÖKER
Arpag, Goker
Arpağ, Göker
Arpag,Goker
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G. Arpağ
Arpağ, G.
Arpaʇ G.
ARPAĞ, Göker
Arpağ G.
Arpağ,G.
A., Göker
Arpag G.
Göker ARPAĞ
Job Title
Dr. Öğr. Üyesi
Email Address
goker.arpag@khas.edu.tr
ORCID ID
0000-0002-6893-2678
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    Article
    Citation - WoS: 1
    Citation - Scopus: 1
    The Gtp-Tubulin Cap Is Not the Determinant of Microtubule End Stability in Cells
    (Amer Soc Cell Biology, 2024) Arpağ, Göker; Farmer,V.; Arpağ,G.; Zanic,M.
    Microtubules are dynamic cytoskeletal polymers essential for cell division, motility, and intracellular transport. Microtubule dynamics are characterized by dynamic instability-the ability of individual microtubules to switch between phases of growth and shrinkage. Dynamic instability can be explained by the GTP-cap model, suggesting that a "cap" of GTP-tubulin subunits at the growing microtubule end has a stabilizing effect, protecting against microtubule catastrophe-the switch from growth to shrinkage. Although the GTP-cap is thought to protect the growing microtubule end, whether the GTP-cap size affects microtubule stability in cells is not known. Notably, microtubule end-binding proteins, EBs, recognize the nucleotide state of tubulin and display comet-like localization at growing microtubule ends, which can be used as a proxy for the GTP-cap. Here, we employ high spatiotemporal resolution imaging to compare the relationship between EB comet size and microtubule dynamics in interphase LLC-PK1 cells to that measured in vitro. Our data reveal that the GTP-cap size in cells scales with the microtubule growth rate in the same way as in vitro. However, we find that microtubule ends in cells can withstand transition to catastrophe even after the EB comet is lost. Thus, our findings suggest that the presence of the GTP-cap is not the determinant of microtubule end stability in cells.