A comparison of erythrocyte superoxide dismutase and catalase activity in patients with hepatitis C infection

dc.contributor.authorBayındır, Yaar
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorSönmez, Emine
dc.contributor.authorGözükara, Engin M.
dc.date.accessioned2021-02-19T10:46:13Z
dc.date.available2021-02-19T10:46:13Z
dc.date.issued2002
dc.description.abstractHepatitis C virus (HCV) infection remains important due to difficulties in treatment up to a chronic state. It is considered that free radicals, lipid peroxidation and antioxidant defense play a role in various tissue damages, just as in certain types of viral hepatitis. Since only limited data has been reported concerning oxidative stress in viral hepatitis, a comparative study was planned for patients with hepatitis C. In this study, we searched for erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities in patients with HCV infection who had received and not received recombinant interferon alpha. Four groups of patients [Group 1: 15 healthy, volunteers served as a control group; Group II: 10 patients with acute HCV infection; Group III: 15 untreated patients with chronic HCV infection; and Group IV: 15 patients who completed six months of interferon therapy (9 million U/week)] were included in the study. In Group I, SOD activity (as means ± standard deviation) was 2213.29 ± 152.01 U/g Hb; in Group II, 2643.03 ± 142.44 U/g Hb; in Group III, 1135.79 ± 122.27 U/g Hb; and in Group IV, 1734.78 ± 183.72 U/g Hb. The difference between the groups was statistically significant (p < 0.05). Erythrocyte means ± standard deviation CAT levels in Group I were 252.10 ± 61.09 K/g Hb; in Group II, 253.37 ± 29.68 K/g Hb; in Group III, 291.80 ± 72.54 K/g Hb; and in Group IV 220.43 ± 36.39 K/g Hb. The difference between Groups I, II and III was not statistically significant (p > 0.05), but was for Groups III and IV (p < 0.005) In conclusion, erythrocyte SOD activity increased in acute hepatitis C patients, but decreased in chronic hepatitis C patients, and this decrease was reversed when treated with interferon.en_US
dc.identifier.citation7
dc.identifier.endpage316en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1300-0144
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0036063582en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage313en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/3955
dc.identifier.volume32en_US
dc.identifier.wosqualityQ4
dc.institutionauthorBayındır, Yaaren_US
dc.language.isoenen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalaseen_US
dc.subjectHepatitis Cen_US
dc.subjectInterferon alphaen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleA comparison of erythrocyte superoxide dismutase and catalase activity in patients with hepatitis C infectionen_US
dc.typeArticleen_US
dspace.entity.typePublication

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