Modulation of high-density lipoproteins in a population in Istanbul Turkey with low levels of high-density lipoproteins

dc.contributor.author Mahley, Robert W.
dc.contributor.author Can, Selçuk
dc.contributor.author Özbayrakçı, Sinan
dc.contributor.author Bersot, Thomas P.
dc.contributor.author Tanir, Sibel
dc.contributor.author Palaoğlu, K. Erhan
dc.contributor.author Pepin, Guy M.
dc.date.accessioned 2019-06-27T08:00:51Z
dc.date.available 2019-06-27T08:00:51Z
dc.date.issued 2005
dc.description.abstract The extent to which high-density lipoprotein (HDL) cholesterol levels can be increased in patients with low HDL cholesterol is important because low HDL cholesterol levels increase the risk of coronary heart disease (CHD). During the past 14 years we have assessed risk factors in Turks a population in which extremely low HDL cholesterol levels (mean 36 mg/dl in men 42 mg/dl in women) are a prime CHD risk factor. Although genetically determined to a significant extent these low HDL cholesterol levels can be modulated by lifestyle factors as in other populations.'We measured the HDL cholesterol levels in men and women residing in Istanbul at 3 time points: 1990 to 1993 1996 to 2000 and 2003. The mean HDL cholesterol levels increased from 45.3 +/- 9.5 mg/dl in 1990 to 1993 to 49.7 +/- 12 mg/dl in 2003 (p < 0.0001) in women but were virtually unchanged in men (38 +/- 8 vs 39 +/- 10 mg/dl). In contrast to previous years the HDL cholesterol levels in women in 2003 were markedly affected by education level and socioeconomic status averaging 56 +/- 9 mg/dl in those with a university education and 48 +/- 12 mg/dl in those with a primary school education. Part of this difference could be explained by less smoking and more exercise and lower body mass index (average 25.6 +/- 4.9 vs 29.7 +/- 5.1 kg/m(2)) of the highly educated women. It is important to note the increase in the prevalence of obesity between the 1990 to 1993 interval and 2003 in men and womenincluding a remarkable change from 9.4% to 45.2% among women with a primary school education. None of these factors affected the HDL cholesterol levels of men by > 2 mg/dl at any of the 3 points. In conclusion because CRD risk changes by as much as 2% to 4% per 1 mg/dl difference in HDL cholesterol level the 8 mg/dl difference may reflect as much as a 20% to 30% reduction in CHD risk associated with the benefit of higher education in women. Why education failed to affect the HDL cholesterol levels in Turkish men remains unclear. (c) 2005 Elsevier Inc. All rights reserved. en_US]
dc.identifier.citationcount 22
dc.identifier.doi 10.1016/j.amjcard.2005.04.018 en_US
dc.identifier.endpage 555
dc.identifier.issn 0002-9149 en_US
dc.identifier.issn 0002-9149
dc.identifier.issue 4
dc.identifier.pmid 16098310 en_US
dc.identifier.scopus 2-s2.0-23644432806 en_US
dc.identifier.scopusquality Q1
dc.identifier.startpage 547 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/123
dc.identifier.uri https://doi.org/10.1016/j.amjcard.2005.04.018
dc.identifier.volume 96 en_US
dc.identifier.wos WOS:000231255100016 en_US
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher EXCERPTA MEDICA INC en_US
dc.relation.journal American Journal of Cardiology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 25
dc.title Modulation of high-density lipoproteins in a population in Istanbul Turkey with low levels of high-density lipoproteins en_US
dc.type Article en_US
dc.wos.citedbyCount 23
dspace.entity.type Publication

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