Thiols malonaldehyde status in the Turkish and total antioxidant patients with type 2 diabetes mellitus

dc.contributor.author Duman, Belgin Süsleyici
dc.contributor.author Öztürk, Melek
dc.contributor.author Yilmazer, Selma
dc.contributor.author Hatemi, Hüsrev
dc.date.accessioned 2019-06-27T08:00:56Z
dc.date.available 2019-06-27T08:00:56Z
dc.date.issued 2003
dc.description.abstract Non-insulin-dependent (Type 2) diabetes mellitus (NIDDM) is a risk factor for cardiovascular diseases (CVD). Oxidative stress mechanisms are often reported to be implied in type 2 diabetes mellitus. In order to determine their clinical relevance we investigated several plasma indicators in the Turkish patients with NIDDM: (1) homocysteine (Hey) and cysteine (Cys) which contribute to increase the risk of atherosclerosis during NIDDM (ii) glutathione (GSH) and cysteinylglycine (CysGly) resulting from GSH degradation catalyzed by gamma-glutamylcysteine transferase (GGT) (iii) malonaldehyde (MDA) as a marker for lipid peroxidation and (iv) total antioxidant status (TAS). Our main results were evaluated based on sex and diabetic status. In female patients plasma concentrations of MDA and Hey were significantly higher than in controls while GSH levels were significantly lower. In males a difference between control and diabetic groups was noticed only for Hey levels being also higher in patients. In the diabetic group increase in serum glucose concentration was significantly correlated with increased GGT activity. In both controls and diabetic patients GGT activity was correlated with a raised Cys concentration and a decreased GSH level. In both controls and diabetic patients there were significant positive correlations between Cys and Hey and between GSH and Hey. We concluded that GSH and MDA levels are clinical indicators for an oxidative process linked to type 2 diabetes mellitus especially in women. en_US]
dc.identifier.citationcount 24
dc.identifier.doi 10.1620/tjem.201.147 en_US
dc.identifier.endpage 155
dc.identifier.issn 0040-8727 en_US
dc.identifier.issn 1349-3329 en_US
dc.identifier.issn 0040-8727
dc.identifier.issn 1349-3329
dc.identifier.issue 3
dc.identifier.pmid 14649736 en_US
dc.identifier.scopus 2-s2.0-0345530940 en_US
dc.identifier.scopusquality Q2
dc.identifier.startpage 147 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/173
dc.identifier.uri https://doi.org/10.1620/tjem.201.147
dc.identifier.volume 201 en_US
dc.identifier.wos WOS:000186693700003 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Tohoku Univ Medical Press en_US
dc.relation.journal Tohoku Journal of Experimental Medicine en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 29
dc.title Thiols malonaldehyde status in the Turkish and total antioxidant patients with type 2 diabetes mellitus en_US
dc.type Article en_US
dc.wos.citedbyCount 24
dspace.entity.type Publication

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