The Involvement of Nitric Oxide in the Analgesic Effects of Ketamine
dc.contributor.author | Bulutcu, Füsun S. | |
dc.contributor.author | Doğrul, Ahmet | |
dc.contributor.author | Güç, M. Oğuz | |
dc.date.accessioned | 2019-06-27T08:01:01Z | |
dc.date.available | 2019-06-27T08:01:01Z | |
dc.date.issued | 2002 | |
dc.description.abstract | We investigated the contribution of NO-cyclic GMP (cGMP) pathway to the antinociceptive effects of ketamine in mice by using the nitric oxide synthase inhibitor nitro(g)-L-arginine methyl ester (L-NAME). Intraperitoneal (i.p.) (1 5 or 10 mg/kg) or intrathecal (i.th.) (10 30 or 60 mug/mouse) administration of ketamine produced dose-dependent antinociceptive effects in the acetic acid-induced writhing and formalin tests but not in the tail-flick nor in hot-plate tests. pretreatment of mice with L-NAME (10 mg/kg i.p.) which produced no antinociception on its own significantly inhibited the antinociceptive effect of ketamine (1 5 or 10 mg/kg i.p.). However L-NAME (30 mug/mouse) was given intrathecally it neither modified the antinociceptive effect of i.th. ketamine (10 3 0 or 60 mug/mouse) nor did it produce an antinociceptive effect alone. These data suggest that the activation of the NO-cGMP pathway probably at the supraspinal level but not spinal level contributes to the antinociceptive effects of ketamine. (C) 2002 Published by Elsevier Science Inc. | en_US] |
dc.identifier.citation | 33 | |
dc.identifier.doi | 10.1016/S0024-3205(02)01765-4 | en_US |
dc.identifier.endpage | 853 | |
dc.identifier.issn | 0024-3205 | en_US |
dc.identifier.issn | 0024-3205 | |
dc.identifier.issue | 7 | |
dc.identifier.pmid | 12074943 | en_US |
dc.identifier.scopus | 2-s2.0-0037025040 | en_US |
dc.identifier.startpage | 841 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12469/212 | |
dc.identifier.uri | https://doi.org/10.1016/S0024-3205(02)01765-4 | |
dc.identifier.volume | 71 | en_US |
dc.identifier.wos | WOS:000177121100012 | en_US |
dc.identifier.wosquality | Q1 | |
dc.institutionauthor | Bulutçu, Füsun S. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
dc.relation.journal | Life Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Ketamine | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | Analgesia | en_US |
dc.subject | NMDA receptors | en_US |
dc.subject | Anaesthetics | en_US |
dc.subject | L-N-G nitro arginine methylester (L-NAME) | en_US |
dc.subject | Formalin | en_US |
dc.subject | Writhing | en_US |
dc.subject | Pain | en_US |
dc.subject | Dissociative anesthesia | en_US |
dc.title | The Involvement of Nitric Oxide in the Analgesic Effects of Ketamine | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication |
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