Diltiazemin internal torasik arter kan akımı üzerine etkisi
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Date
1996
Authors
Akpinar, Belhhan
Çetin, Gürkan
Bayındır, Osman
Cakali, Emine
Pekcan, Ülkü
Sönmez, Bingür
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Abstract
Bir kalsiyum antagonist! olan diltiazemin koroner arter cerrahisinde internal torasik arter (İTA) akımı üzerindeki etkisini incelemek üzere 60 olgu üzerinde yapılan çalışmada, 30 olguya peroperatif 0.1 mg/kg/saat - 0.3 mg /kg / saat arasında değişen dozlarda diltiazem perfüzyonu başlandı ve 24 saat devam edildi (Grup 1). Diğer 30 olguya (Grup 2) diltiazem verilmedi. Yapılan ölçümlerde İTA kan akımı Grup Vde 110 ± 5 ml/dk, Grup 2'de 70 ± 7 mi/ dk bulundu (p < 0.05). Grup 2'deki olgulara İTA içine papaverin enjekte edildikten sonra yapılan ölçümlerde İTA kan akımı 120 ± 5 mi olarak ölçüldü. Elde edilen gözlem, peroperatif başlanan diltiazem perfüzyonunun İTA kan akımını önemli ölçüde artırdığı şeklindedir.
This prospective, randomized study was performed on 60 patients to evaluate the effects of diltiazem on internal thoracic artery (ITA flow. Thirty patients. (Group 1) received a minimum dose of 0.1 mg / kg /hr diltiazem perfusion perioperatively which was continued for 24 hours in the intensive care unit. The other 30 patients (Group 2) did not recieve diltiazem. The ITA flow, measured just before the start of cardiopulmonary bypass (C.P.B.) was 110 ± 5 ml /min in Group 1 and 70± 7 ml/min in Group 2 (p < 0,05). Diluted papaverin solution was injected in İTA s in Group 2 and in the repeated measurement, the ITA flow was measured as 120 ± 5 ml/min. These initial results suggest that perioperative diltiazem perfusion increases ITA flow significantly and prevents spasm in the early operative period.
This prospective, randomized study was performed on 60 patients to evaluate the effects of diltiazem on internal thoracic artery (ITA flow. Thirty patients. (Group 1) received a minimum dose of 0.1 mg / kg /hr diltiazem perfusion perioperatively which was continued for 24 hours in the intensive care unit. The other 30 patients (Group 2) did not recieve diltiazem. The ITA flow, measured just before the start of cardiopulmonary bypass (C.P.B.) was 110 ± 5 ml /min in Group 1 and 70± 7 ml/min in Group 2 (p < 0,05). Diluted papaverin solution was injected in İTA s in Group 2 and in the repeated measurement, the ITA flow was measured as 120 ± 5 ml/min. These initial results suggest that perioperative diltiazem perfusion increases ITA flow significantly and prevents spasm in the early operative period.
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Volume
35
Issue
3-4
Start Page
153
End Page
155