Prospective evaluation of platelets prepared by single and random methods during 5 days of storage: aspects related to quality and quantity

dc.contributor.authorKocazeybek, Bekir Sami
dc.contributor.authorArabaci, Ümit Önel
dc.contributor.authorAkdur, Hülya
dc.contributor.authorSezgiç, Metin
dc.contributor.authorErentürk, Şaduman
dc.date.accessioned2019-06-27T08:01:02Z
dc.date.available2019-06-27T08:01:02Z
dc.date.issued2002
dc.description.abstractPlatelets which have an important role in hemostatic mechanisms and which were prepared by single and random methods were investigated to measure quantity and aggregation response during 5 days of storage. The aggregation response and quantitative values of platelet concentrates (PCs) 60 of which were prepared by a single donor method and 62 by a random method were investigated during the 1st 3rd and 5th days of storage. The single donor platelets (SDP) were obtained by using the MCS Plus apheresis device and the random donor platelets (RDP) were obtained by two-phase centrifugation in the Heraeus 8500i centrifuge device (during the first phase platelet rich plasma was obtained then platelet concentrate was obtained from this product) and were stored at 22 degreesC on a circular agitator. In addition pH PO2 PCO2 glucose and lactate values were measured in order to evaluate the effects of storage. The aggregation response was measured using adenosine diphosphate (ADP) epinephrine (EPN) collagen (COLL) and ristocetin (RIST). The cell count in mm(3) and the total cell count were also measured. The total cell counts and cells in mm(3) of the PCs which were prepared by the single donar method on the 1st 3rd and 5th days were: 3.11 x 10(11) 3.09 x 10(11) 3.07 x 10(11) and 292 x 10(3) 290 x 10(3) 289 x 10(3) and of those prepared by the random method were: 5.71 x 10(10) 5.69 x 10(10) 5.66 x 10(10) and 156 x 10(3) 153 x 10(3) 151 x 10(3). The mean aggregation responses of the PCs prepared by the two methods on the 1st 3rd and 5th days expressed as a 'X were: ADP: 94.8-93.2 81.6 78.7 44.3-8.2en_US]
dc.description.abstractCOLL: 91.7-89.6 79.2-74.2 29.8-11.1. EPN: 88.5-91.3 64.2-62.7 39.4-4.5 and RIST: 89.4-89.4 76.5-73.6 14.4-3.2. Other data related to platelet storage were obtained by measuring the pH PO2 PCO2 glucose and lactate levels of the PCs. In our study it was determined that in spite of the optimal storage conditions the aggregation response of the PCs decreased significantly whereas the numerical values changed little during the storage period. (C) 2002 Elsevier Science Ltd. All rights reserved.en_US]
dc.identifier.citation15
dc.identifier.doi10.1016/S1473-0502(01)00141-0en_US
dc.identifier.endpage34
dc.identifier.issn1473-0502en_US
dc.identifier.issn1473-0502
dc.identifier.issue1
dc.identifier.pmid11931375en_US
dc.identifier.scopus2-s2.0-0035991919en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage29en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/225
dc.identifier.urihttps://doi.org/10.1016/S1473-0502(01)00141-0
dc.identifier.volume26en_US
dc.identifier.wosWOS:000174751900003en_US
dc.identifier.wosqualityN/A
dc.institutionauthorSezgiç, Metinen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.journalTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlateletsen_US
dc.subjectAggregationen_US
dc.subjectPlatelet countsen_US
dc.subjectSingle methoden_US
dc.subjectRandom methoden_US
dc.titleProspective evaluation of platelets prepared by single and random methods during 5 days of storage: aspects related to quality and quantityen_US
dc.typeArticleen_US
dspace.entity.typePublication

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