Which May Be Effective To Reduce Blood Loss After Cardiac Operations in Cyanotic Children: Tranexamic Acid Aprotinin or a Combination?

dc.contributor.author Bulutcu, Füsun S.
dc.contributor.author Özbek, Uğur
dc.contributor.author Polat, Bülent
dc.contributor.author Yalcçın, Yalim
dc.contributor.author Karaci, A.R.
dc.contributor.author Bayındır, Osman
dc.date.accessioned 2019-06-27T08:00:53Z
dc.date.available 2019-06-27T08:00:53Z
dc.date.issued 2005
dc.description.abstract Background: Children with cyanotic heart disease undergoing cardiac surgery in which cardiopulmonary bypass is used are at increased risk of postoperative bleeding. In this study the authors investigated the possibility of reducing postoperative blood loss by using aprotinin and tranexamic acid alone or a combination of these two agents. Methods: In a prospective randomized blind study 100 children undergoing cardiac surgery were investigated. In group 1 (n = 25) patients acted as the control and did not receive either study drugs. In group 2 (n = 25) patients received aprotinin (30.000 KIU.kg(-1) after induction of anesthesia 30.000 KIU.kg(-1) in the pump prime and 30.000 KIU.kg(-1) after weaning from bypass). In group 3 (n = 25) patients received tranexamic acid (100 mg.kg(-1) after induction of anesthesia 100 mg.kg(-1) in the pump prime and 100 mg.kg(-1) after weaning from bypass). In group 4 (n = 25) patients received a combination of the two agents in the same manner. Total blood loss and transfusion requirements during the period from protamine administration until 24 h after admission to the intensive care unit were recorded. In addition hemoglobin platelet counts and coagulation studies were recorded. Results: Postoperative blood loss was significantly higher in the control group (group 1) compared with children in other groups who were treated with aprotinin tranexamic acid or a combination of the two agents (groups 2 3 and 4) during the first 24 h after admission to cardiac intensive care unit (40 +/- 18 ml.kg(-1).24 h(-1) aprotinin en_US]
dc.description.abstract 35 +/- 16 ml.kg(-1).24 h(-1) tranexamic acid en_US]
dc.description.abstract 34 +/- 19 ml.kg(-1).24 h(-1) combination en_US]
dc.description.abstract 35 +/- 15 ml.kg(-1).24 h(-1)). The total transfusion requirements were also significantly less in the all treatment groups. Time taken for sternal closure was longer in the control group (68 +/- 11 min) compared with treatment groups 2 3 and 4 respectively (40 +/- 18 42 +/- 11 42 +/- 13 min P < 0.05). The coagulation parameters were not found to be significantly different between the three groups. Conclusions: Our results suggested that both agents were effective to reduce postoperative blood loss and transfusion requirements in patients with cyanotic congenital heart disease. However the combination of aprotinin and tranexamic acid did not seem more effective than either of the two drugs alone. en_US]
dc.identifier.citationcount 56
dc.identifier.doi 10.1111/j.1460-9592.2004.01366.x en_US
dc.identifier.endpage 46
dc.identifier.issn 1155-5645 en_US
dc.identifier.issn 1155-5645
dc.identifier.issue 1
dc.identifier.pmid 15649162 en_US
dc.identifier.scopus 2-s2.0-13244295652 en_US
dc.identifier.scopusquality Q2
dc.identifier.startpage 41 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/140
dc.identifier.uri https://doi.org/10.1111/j.1460-9592.2004.01366.x
dc.identifier.volume 15 en_US
dc.identifier.wos WOS:000226426000008 en_US
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Blackwell Publishing Ltd en_US
dc.relation.journal Pediatric Anesthesia en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 75
dc.subject Cyanosis en_US
dc.subject Children en_US
dc.subject Aprotinin en_US
dc.subject Tranexamic acid en_US
dc.subject Heart disease en_US
dc.title Which May Be Effective To Reduce Blood Loss After Cardiac Operations in Cyanotic Children: Tranexamic Acid Aprotinin or a Combination? en_US
dc.type Article en_US
dc.wos.citedbyCount 57
dspace.entity.type Publication

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