Influence of Combined Antioxidants Against Cadmium Induced Testicular Damage

dc.contributor.author Koyutürk, Meral
dc.contributor.author Yanardağ, Refiye
dc.contributor.author Bolkent, Şehnaz
dc.contributor.author Tunalı, Sevim
dc.date.accessioned 2019-06-27T08:06:49Z
dc.date.available 2019-06-27T08:06:49Z
dc.date.issued 2006
dc.description.abstract Acute effects ofcadmium (Cd) and combined antioxidants were evaluated in Sprague-Dawley rat testes. The rats were subdivided into four groups. Cadmium chloride (2 mg/kg day) injected intraperitoneally during 8 days. Vitamin C (250 mg/kg day) vitamin E (250 rng/kgday) and sodium selenate (0.25 mg/kg day) were pretreated by gavage in both ofcontrol and cadmium injected rats. Testis lipid peroxidation and glutathione levels were determined by spectrophotometrically. In Cd treated rats lipid peroxidation levels were increased and glutathione levels were decreased and combined antioxidants treatment was effective in preventing of lipid peroxidation and normalizing glutathione. In Cd treated animals the degenerative changes were observed but not observed in the administrated rats with Cd and antioxidantS Linder the light microscope. Proliferating cell nuclear antigen metal loth ionei n and caspase-3 activities were evaluated by irninunohistochernically. Proliferation activity was not seen in the spermatogonial cells of cadmium treated testis. Treatment with antioxidarils in cadmium administrated testis leads to pronounced increase in proliferation activity. Cytoplasmic caspase-3 activity was determined in the sperinatogenic cells but not speri-natogonia in treatment of ant ioxidants with Cd. In control and treated with antioxidants animals metallothionein expressions were localized in the cells of serainiferous tubules although the expression only was observed in the interstitial cells of cadmium treated rats. Results demonstrated beneficial effects of combined vitamin C vitamin E and selenium treatment in Cd toxicity. (c) 2005 Elsevier B.V. All rights reserved. en_US]
dc.identifier.citationcount 49
dc.identifier.doi 10.1016/j.ctap.2005.08.006 en_US
dc.identifier.endpage 240
dc.identifier.issn 1382-6689 en_US
dc.identifier.issn 1872-7077 en_US
dc.identifier.issn 1382-6689
dc.identifier.issn 1872-7077
dc.identifier.issue 3
dc.identifier.pmid 21783663 en_US
dc.identifier.scopus 2-s2.0-33645223453 en_US
dc.identifier.scopusquality Q1
dc.identifier.startpage 235 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/1232
dc.identifier.uri https://doi.org/10.1016/j.etap.2005.08.006
dc.identifier.volume 21 en_US
dc.identifier.wos WOS:000237127000003 en_US
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Elsevier Science Bv en_US
dc.relation.journal Environmental Toxicology And Pharmacology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 52
dc.subject Antioxidants en_US
dc.subject Cadmium en_US
dc.subject Rat en_US
dc.subject Testis en_US
dc.title Influence of Combined Antioxidants Against Cadmium Induced Testicular Damage en_US
dc.type Article en_US
dc.wos.citedbyCount 49
dspace.entity.type Publication

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Influence of combined antioxidants against cadmium induced testicular damage.pdf
Size:
333.38 KB
Format:
Adobe Portable Document Format
Description: