Biclustering Expression Data Based on Expanding Localized Substructures

dc.contributor.author Erten, Cesim
dc.contributor.author Erten, Cesim
dc.contributor.author Sözdinler, Melih
dc.contributor.other Computer Engineering
dc.date.accessioned 2019-06-27T08:05:47Z
dc.date.available 2019-06-27T08:05:47Z
dc.date.issued 2009
dc.department Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü en_US
dc.description.abstract Biclustering gene expression data is the problem of extracting submatrices of genes and conditions exhibiting significant correlation across both the rows and the columns of a data matrix of expression values. We provide a method LEB (Localize-and-Extract Biclusters) which reduces the search space into local neighborhoods within the matrix by first localizing correlated structures. The localization procedure takes its roots from effective use of graph-theoretical methods applied to problems exhibiting a similar structure to that of biclustering. Once interesting structures are localized the search space reduces to small neighborhoods and the biclusters are extracted from these localities. We evaluate the effectiveness of our method with extensive experiments both using artificial and real datasets. en_US]
dc.identifier.citationcount 5
dc.identifier.doi 10.1007/978-3-642-00727-9_22 en_US
dc.identifier.endpage +
dc.identifier.isbn 978-3-642-00726-2
dc.identifier.issn 0302-9743 en_US
dc.identifier.issn 1611-3349 en_US
dc.identifier.issn 0302-9743
dc.identifier.issn 1611-3349
dc.identifier.scopus 2-s2.0-68249117368 en_US
dc.identifier.scopusquality Q2
dc.identifier.startpage 224 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/1116
dc.identifier.uri https://doi.org/10.1007/978-3-642-00727-9_22
dc.identifier.volume 5462 en_US
dc.identifier.wos WOS:000265785800022 en_US
dc.institutionauthor Erten, Cesim en_US
dc.institutionauthor Erten, Cesim en_US
dc.language.iso en en_US
dc.publisher Springer-Verlag Berlin en_US
dc.relation.journal International Conference on Bioinformatics and Computational Biology en_US
dc.relation.publicationcategory Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 7
dc.title Biclustering Expression Data Based on Expanding Localized Substructures en_US
dc.type Conference Object en_US
dc.wos.citedbyCount 5
dspace.entity.type Publication
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