The interrelationship between insulin secretion and action in Type 2 diabetes mellitus with different degrees of obesity: Evidence supporting central obesity

dc.contributor.authorDuman, Belgin Süsleyici
dc.contributor.authorTürkoğlu, Cengizhan
dc.contributor.authorGünay, Demet
dc.contributor.authorÇağatay, Penbe
dc.contributor.authorDemiroğlu, C
dc.contributor.authorBüyükdevrim, Ahmet Sevim
dc.date.accessioned2019-06-27T08:00:57Z
dc.date.available2019-06-27T08:00:57Z
dc.date.issued2003
dc.description.abstractThis paper investigates the relative role of the impairment of insulin secretion and action in the pathogenesis of Type 2 diabetes mellitus (T2DM). The parameters indicating insulin secretion and action were calculated from the data obtained during oral glucose tolerance test (OGTT) in 156 age- and sex-matched T2DM patients divided in 4 groups according to their body mass index (BMI I=20.0-24.9 II=25.0-29.9 III=30.0-39.9 and IV>40.0 kg/m(2)). After obtaining baseline biomedical parameters (plasma glucose serum insulin cholesterol HDL-cholesterol triglycerides BMI and amount of fat tissue) the rates of insulin secretory capacity and insulin action were obtained from OGTT and compared between the T2DM patients with normal body weight and different grades of obesity. Beta-cell secretory capacity of the participants was found to be proportionally and significantly higher in graded obese than that of the normal body weight patients. The rates of hepatic as well as peripheral insulin resistance in obese groups proportionally and significantly rise in comparison with that of non-obese diabetics. In addition these parameters are shown to be related to the body fat presumably visceral in origin. In conclusion hyperglycemia-hyperinsulinemia observed in obese and T2DM patients might be due in part to increased capacity of insulin secretion and to exaggerated hepatic glucose production because of hepatic insulin resistance respectively. (C) 2003 Editrice Kurtis.en_US]
dc.identifier.citation16
dc.identifier.endpage250
dc.identifier.issn0394-3402en_US
dc.identifier.issn0394-3402
dc.identifier.issue4
dc.identifier.pmid14768774en_US
dc.identifier.scopus2-s2.0-0347031667en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage243en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/180
dc.identifier.urihttps://www.semanticscholar.org/paper/The-interrelationship-between-insulin-secretion-and-Duman-Turkoglu/4792a56766f1f84bc064981e0c1039f46822a0ed
dc.identifier.volume16en_US
dc.identifier.wosWOS:000187502000006en_US
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.journalDiabetes Nutrition & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInsulin secretionen_US
dc.subjectInsulin sensitivityen_US
dc.subjectAbdominal obesityen_US
dc.subjectBeta-cell indexen_US
dc.subjectInsulin resistanceen_US
dc.titleThe interrelationship between insulin secretion and action in Type 2 diabetes mellitus with different degrees of obesity: Evidence supporting central obesityen_US
dc.typeArticleen_US
dspace.entity.typePublication

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