Lipid Peroxidation and Osmotic Fragility of Red Blood Cells in Sleep-Apnea Patients

dc.contributor.authorÖztürk, Levent
dc.contributor.authorMansour, Bayat
dc.contributor.authorYüksel, Meral
dc.contributor.authorYılmaz, Ayşe Mine
dc.contributor.authorÇelikoğlu, Seyhan I.
dc.contributor.authorGökhan-Kelekçi, Nesrin
dc.date.accessioned2019-06-27T08:00:57Z
dc.date.available2019-06-27T08:00:57Z
dc.date.issued2003
dc.description.abstractBackground: Obstructive sleep apnea (OSA) refers to the occurrence of episodes of complete or partial pharyngeal obstruction with oxyhemoglobin desaturation during sleep. These hypoxia/reoxygenation episodes may cause generation of reactive oxygen species. Reactive oxygen species are toxic to biomembranes and may lead to the peroxidation of lipids. We tested the hypothesis that obstructive sleep apnea is linked to increased oxidative stress and lipid peroxidation. In order to identify target tissue/cell damage we studied the osmotic fragility of red blood cells. Methods: Six subjects polysomnographically diagnosed as obstructive sleep apnea syndrome and 10 controls were included. After all subjects gave written informed consent blood samples were collected in the morning between 08:00 and 09:00 a.m. following polysomnography. Blood samples were immediately transferred to the laboratory. Glutathione lipid peroxidation and osmotic fragility of red blood cells were measured manually. Results: Mean glutathione and lipid peroxidation concentrations of patients were not different than those of control subjects (105.6 +/- 38.6 U/g Hb and 3.1 +/- 2.3 nmol MDA/l vs. 100.6 +/- 62.1 U/g Hb and 3.2 +/- 2.8 nmol MDA/l respectively). In both groups osmotic fragility of red blood cells was not changed. Conclusion: The present study failed to support the hypothesis that obstructive sleep apnea is linked with increased oxidative stress and lipid peroxidation. (C) 2003 Elsevier Science B.V. All rights reserved.en_US]
dc.identifier.citation63
dc.identifier.doi10.1016/S0009-8981(03)00126-8en_US
dc.identifier.endpage88
dc.identifier.issn0009-8981en_US
dc.identifier.issn0009-8981
dc.identifier.pmid12763284en_US
dc.identifier.scopus2-s2.0-0038324393en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage83en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/183
dc.identifier.urihttps://doi.org/10.1016/S0009-8981(03)00126-8
dc.identifier.volume332en_US
dc.identifier.wosWOS:000183342300012en_US
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.journalClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSleep apneaen_US
dc.subjectLipid peroxidationen_US
dc.subjectOsmotic fragilityen_US
dc.subjectGlutathioneen_US
dc.titleLipid Peroxidation and Osmotic Fragility of Red Blood Cells in Sleep-Apnea Patientsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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