Lipid Peroxidation and Osmotic Fragility of Red Blood Cells in Sleep-Apnea Patients

dc.contributor.author Öztürk, Levent
dc.contributor.author Mansour, Bayat
dc.contributor.author Yüksel, Meral
dc.contributor.author Yılmaz, Ayşe Mine
dc.contributor.author Çelikoğlu, Seyhan I.
dc.contributor.author Gökhan-Kelekçi, Nesrin
dc.date.accessioned 2019-06-27T08:00:57Z
dc.date.available 2019-06-27T08:00:57Z
dc.date.issued 2003
dc.description.abstract Background: Obstructive sleep apnea (OSA) refers to the occurrence of episodes of complete or partial pharyngeal obstruction with oxyhemoglobin desaturation during sleep. These hypoxia/reoxygenation episodes may cause generation of reactive oxygen species. Reactive oxygen species are toxic to biomembranes and may lead to the peroxidation of lipids. We tested the hypothesis that obstructive sleep apnea is linked to increased oxidative stress and lipid peroxidation. In order to identify target tissue/cell damage we studied the osmotic fragility of red blood cells. Methods: Six subjects polysomnographically diagnosed as obstructive sleep apnea syndrome and 10 controls were included. After all subjects gave written informed consent blood samples were collected in the morning between 08:00 and 09:00 a.m. following polysomnography. Blood samples were immediately transferred to the laboratory. Glutathione lipid peroxidation and osmotic fragility of red blood cells were measured manually. Results: Mean glutathione and lipid peroxidation concentrations of patients were not different than those of control subjects (105.6 +/- 38.6 U/g Hb and 3.1 +/- 2.3 nmol MDA/l vs. 100.6 +/- 62.1 U/g Hb and 3.2 +/- 2.8 nmol MDA/l respectively). In both groups osmotic fragility of red blood cells was not changed. Conclusion: The present study failed to support the hypothesis that obstructive sleep apnea is linked with increased oxidative stress and lipid peroxidation. (C) 2003 Elsevier Science B.V. All rights reserved. en_US]
dc.identifier.citationcount 63
dc.identifier.doi 10.1016/S0009-8981(03)00126-8 en_US
dc.identifier.endpage 88
dc.identifier.issn 0009-8981 en_US
dc.identifier.issn 0009-8981
dc.identifier.pmid 12763284 en_US
dc.identifier.scopus 2-s2.0-0038324393 en_US
dc.identifier.scopusquality Q1
dc.identifier.startpage 83 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/183
dc.identifier.uri https://doi.org/10.1016/S0009-8981(03)00126-8
dc.identifier.volume 332 en_US
dc.identifier.wos WOS:000183342300012 en_US
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Elsevier Science Bv en_US
dc.relation.journal Clinica Chimica Acta en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 66
dc.subject Sleep apnea en_US
dc.subject Lipid peroxidation en_US
dc.subject Osmotic fragility en_US
dc.subject Glutathione en_US
dc.title Lipid Peroxidation and Osmotic Fragility of Red Blood Cells in Sleep-Apnea Patients en_US
dc.type Article en_US
dc.wos.citedbyCount 63
dspace.entity.type Publication

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