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In silico screening of potential peroxisome proliferator-activated receptors (Alpha-gamma) ppars ?/? for the treatment of human diabetic mellitus (DM)
(Kadir Has Üniversitesi, 2020) Yelekçi, Kemal; Yelekçi, Kemal
Diabetes mellitus (DM) means a metabolic ailment identified by hyperglycemia, obesity, hypertension, which can contribute to the metabolic disturbances on sugars, lipids, and protein. PPARα and PPARγ become signified the common broadly reviewed Peroxisome proliferator-activated receptor (PPAR) subtypes of Nuclear receptors because of their significant jobs in managing glucose, lipids, and cholesterol digestion. Throughout combining the lowering serum triglyceride levels benefit of PPARα agonists (as fibrates) with the glycemic advantages of the PPARγ agonists (as TZD), the dual PPAR agonists approach can both improve the metabolic impacts and limit the symptoms brought about by either operator alone, and subsequently, has become a promising system for planning powerful medications against type-2 diabetes (T2DM). The result in this study, we performed computer procedures to gain one compound ZINC000002805504 with high -binding score low toxicity from the ZINC15 database through (CBP) models virtual screening. The compounds ZINC000002805504, ZINC000058367624 were found, which could activate PPARα and PPARγ receptors as the anti-diabetic. Our research has provided a design for gaining the potential of both PPARα/γ agonists to diabetes therapy.