Browsing by Author "Akpinar, Belhhan"

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Citation Count: 0
11 beta-HSD type 1 is responsible for low plasma hdl-cholesterol and abdominal obesity in metabolic syndrome patients
(Blackwell Publishing Ltd, 2006) Atalar, Fatmahan; Vural, Burçak; Ciftci, C.; Demirkan, A.; Susleyici Duman, Belgin; Çağatay, Penbe; Günay, Demet; Sagbas, E.; Akpinar, Belhhan; Ozbek, Ugur; Buyukdevrim, Ahmet Sevim
[Abstract Not Available]
Citation Count: 0
Diltiazemin internal torasik arter kan akımı üzerine etkisi
(1996) Akpinar, Belhhan; Çetin, Gürkan; Bayındır, Osman; Cakali, Emine; Pekcan, Ülkü; Sönmez, Bingür
Bir kalsiyum antagonist! olan diltiazemin koroner arter cerrahisinde internal torasik arter (İTA) akımı üzerindeki etkisini incelemek üzere 60 olgu üzerinde yapılan çalışmada, 30 olguya peroperatif 0.1 mg/kg/saat - 0.3 mg /kg / saat arasında değişen dozlarda diltiazem perfüzyonu başlandı ve 24 saat devam edildi (Grup 1). Diğer 30 olguya (Grup 2) diltiazem verilmedi. Yapılan ölçümlerde İTA kan akımı Grup Vde 110 ± 5 ml/dk, Grup 2'de 70 ± 7 mi/ dk bulundu (p < 0.05). Grup 2'deki olgulara İTA içine papaverin enjekte edildikten sonra yapılan ölçümlerde İTA kan akımı 120 ± 5 mi olarak ölçüldü. Elde edilen gözlem, peroperatif başlanan diltiazem perfüzyonunun İTA kan akımını önemli ölçüde artırdığı şeklindedir.
Citation Count: 9
Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease
(COLL AMER PATHOLOGISTS, 2004) Duman, Belgin Süsleyici; Türkoğlu, Caner; Akpinar, Belhhan; Güden, Mustafa; Vertii, Alexey; Dak, Esranur; Çağatay, Tülin; Günay, Demet; Buyukdevrim, Ahmet Sevim
Context.-Lipoprotein lipase (LPL) plays a central role in lipid metabolism hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins. The PvuII polymorphic variant of LPL gene is common and might affect risk of coronary artery disease (CAD). Objective.-Our aim was to determine whether LPL-PvuII polymorphism can be considered to be an independent risk factor or a predictor for CAD in Turkish subjects. Design.-We used polymerase chain reaction and restriction enzyme digestion to determine the distribution of the previously described C-->T transition that causes a PvuII polymorphism in intron 6 among healthy blood donors of Turkish origin and among angiographically confirmed CAD patients with comparable ethnic backgrounds. Results.-For the PvuII genotypes within the CAD group (n = 80) the +/- genotype was found in 39 individuals (48.8%) whereas 25 (31.3%) carried the +/+ genotype and 14 (17.5%) carried the -/- genotype. Within the control group (n = 49) the -/- genotype was found in 19 individuals (38.8%) 16 (32.7%) carried the +/- genotype and 14 (28.6%) carried the +/+ genotype. The genotype frequency distribution was significantly different (P = .049) in the CAD and control study groups. The most frequent genotype among CAD patients was +/-
Citation Count: 0
Time flow measurements (TTFM) differ between grafts do transit performed on and off-pump CABG? a comparitive study
(Forum Multimedia Publishing LLC., 2002) Güden, Mustafa; Akpinar, Belhhan; Sağbaş, Ertan; Sanisoğlu, İlhan; Bayındır, Osman
Background: The aim of this study was to compare intraoperative coronary graft flows performed on and off-pump and to evaluate the effects of hemodilution on coronary graft flows in off-pump CABG patients by using TTFM. Materials and Methods: During a one year period 150 patients undergoing a CABG only procedure were enrolled in a prospective randomized manner. Group 1 consisted of 50 patients undergoing CABG using standard CPB techniques. Group 2 consisted of 50 cases who were planned to undergo revascularization using off-pump techniques. Group 3 consisted of 50 patients undergoing CABG using off-pump techniques under controlled hemodilution. (Htc% levels were kept between a range of 25-28%.) TTFM were performed using the CTS (Cardiothoracic Systems) - USA flometer. Mean Flows (Qmed) Pulsatile _ndex (PI) and flow patterns were evaluated. Twenty-five patients in each group were randomly assigned for control angiography 6 days postoperatively. Reoperations combined cases and emergency operations were not included. Patients requiring high doses of vasoactive drugs were also excluded for the benefit of a controlled vascular resistance. Results: The mean number of anastomoses were higher in Group 1 when compared to Group 2 and 3. (p < 0.05) Mean Arterial Pressure (MAP) heart rate (HR) were similar between groups during measurements. Hematocrit values in Group 2 were higher than Group 1 and Group 3 (p < 0.05). Mean flows (Qmed) for LAD and RCA territories were significantly lower in Group 2 patients (p < 0.05) For the circumflex artery territory despite lower flows again in Group 2 this did not reach significant levels. The pulsatile index were similar in all three groups for all three coronary territories. Postoperative coronary angiography revealed similar graft patencies among three groups (p = ns). All values are shown as mean + SD unless expressed otherwise. The Kruskal-Wallis H test was used for analysing differences between three groups. Dunn's Multiple Comparison test was used for sub-group analysis p < 0.05 was considered significant. Conclusions: Off-pump CABG patients with hemodilution had significantly higher graft flows compared to off-pump CABG patients without hemodilution. It can be hypothesed that hemodilution may help to improve graft patency during the early postoperative period in off-pump CABG patients.