PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12469/4466

Browse

Now showing 1 - 5 of 5

Citation - WoS: 2
Citation - Scopus: 2
Altered Dynamics of S. Aureus Phosphofructokinase Via Bond Restraints at Two Distinct Allosteric Binding Sites
(Academic Press Ltd- Elsevier Science Ltd, 2022) Celebi, Metehan; Akten, Ebru Demet
The effect of perturbation at the allosteric site was investigated through several replicas of molecular dynamics (MD) simulations conducted on bacterial phosphofructokinase (SaPFK). In our previous work, an alternative binding site was estimated to be allosteric in addition to the experimentally reported one. To highlight the effect of both allosteric sites on receptor's dynamics, MD runs were carried out on apo forms with and without perturbation. Perturbation was achieved via incorporating multiple bond restraints for residue pairs located at the allosteric site. Restraints applied to the predicted site caused one dimer to stiffen, whereas an increase in mobility was detected in the same dimer when the experimentally resolved site was restrained. Fluctuations in C-alpha-C-alpha distances which is used to disclose residues with high potential of communication indicated a marked increase in signal transmission within each dimer as the receptor switched to a restrained state. Cross-correlation of positional fluctuations indicated an overall decrease in the magnitude of both positive and negative correlations when restraints were employed on the predicted allosteric site whereas an exact opposite effect was observed for the reported site. Finally, mutual correspondence between positional fluctuations noticeably increased with restraints on predicted allosteric site, whereas an opposite effect was observed for restraints applied on experimentally reported one. In view of these findings, it is clear that the perturbation of either one of two allosteric sites effected the dynamics of the receptor with a distinct and contrasting character. (c) 2022 Elsevier Ltd. All rights reserved.
Citation - WoS: 2
Citation - Scopus: 2
Economic Uncertainty and Climate Change Exposure
(Academic Press Ltd- Elsevier Science Ltd, 2025) Danisman, Gamze Ozturk; Bilyay-Erdogan, Seda; Demir, Ender
This paper explores how economic uncertainty affects firms' climate change exposure. We use an extensive sample from 24 countries from 2002 to 2021. Employing a novel measure of firm-level climate change exposure developed by Sautner et al. (2023b), we empirically demonstrate that prior to the Paris Agreement in 2015, economic uncertainty leads to a decrease in climate change disclosures. However, after the Paris Agreement, our findings reveal a positive association between economic uncertainty and climate change exposure. The positive disclosure effect is primarily driven by higher climate-related opportunities and regulatory exposures. Our findings are robust when we employ alternative definitions for economic uncertainty, alternative samples, additional firm-level and country-level control variables, and alternative methodologies. We find that institutional and foreign ownership positively moderates the association between economic uncertainty and climate change exposure after the Paris Agreement. Further analysis investigates the moderating impact of country-level environmental performance indicators. We present novel empirical evidence suggesting that firms operating in countries with less climate vulnerability, higher readiness, more stringent environmental policies, superior climate protection performance, and higher environmental litigation risk tend to have higher climate change exposure in uncertain times.
Citation - WoS: 14
Citation - Scopus: 15
The effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effect
(Academic Press Ltd- Elsevier Science Ltd, 2023) Rasmi, Yousef; Jalali, Ladan; Khalid, Saliha; Shokati, Ameneh; Tyagi, Poonam; Ozturk, Alpaslan; Nasimfar, Amir
Prolactin (PRL) is an endocrine hormone secreted by the anterior pituitary gland that has a variety of physiological effects, including milk production, immune system regulation, and anti-inflammatory effects. Elevated levels of PRL have been found in several viral infections, including 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), a viral pathogen that has recently spread worldwide. PRL production is increased in SARS-CoV2 infection. While PRL can trigger the production of proinflammatory cytokines, it also has several anti-inflammatory effects that can reduce hyperinflammation. The exact mechanism of PRL's contribution to the severity of COVID-19 is unknown. The purpose of this review is to discuss the interaction between PRL and SARS-CoV2 infection and its possible association with the severity of COVID-19.
Exploring the spatial mental associations of distinct food types
(Academic Press Ltd- Elsevier Science Ltd, 2024) Okur, Betul; Gokce, Ahu
Previous research explored the spatial representations of healthy low -calorie and unhealthy high -calorie food items, revealing an association of healthy low -calorie food with left and top sides, and unhealthy/high-calorie food with right and top sides. This association, namely side bias, was limited to these specific categories leaving the representations of healthy high -calorie and unhealthy low -calorie food categories yet to be explored. Present study was designed to examine the spatial representation of four food categories (unhealthy low -calorie, unhealthy high -calorie, healthy low -calorie, healthy high -calorie) using a computerized food placement task. In Experiment 1, participants placed four food items from different categories into eight locations. In Experiment 2, identical task was used with the addition of centrally presented anchor food item to investigate the mental representation of food items in relation to each other. The frequency of placing food items in specific spatial locations were measured. The results of Experiment 1 provided partial support for side bias. However, the use of anchor items in Experiment 2 provided compelling evidence for vertical side bias, demonstrating consistent pattern of placing healthy foods on the upper sides and unhealthy foods on the lower sides. In both experiments, real -life food choices were examined to investigate whether the high -calorie bias would be observed in actual food choice behavior. The results from both experiments indicated strong preference to select high -calorie foods, supporting high -calorie bias. Overall, this study extends the evidence on the spatial representations of distinct food categories.
Citation - WoS: 2
An Online Diary Study Testing the Role of Functional and Dysfunctional Self-Licensing in Unhealthy Snacking
(Academic Press Ltd- Elsevier Science Ltd, 2023) Sezer, Berke; Oner, Sezin
In the present study, we aimed to investigate how two types of self-licensing (functional and dysfunctional selflicensing) are related to unhealthy snack consumption. Self-licensing refers to the act of using justifications before gratifications and has been associated with higher snack consumption. Previous research has found that while functional self-licensing decreases unhealthy snack consumption, dysfunctional self-licensing increases the number of calories taken from unhealthy snacks. Building upon existing evidence, we addressed functional and dysfunctional self-licensing to investigate how self-licensing behaviors are associated with daily variables (i.e., stress and sleep) and unhealthy snacking habits. Participants (N = 124) were given a battery of measures at the start of the week and asked to send their snack consumption every night for a week via an online questionnaire, along with daily stress and sleep items. The data were analyzed with Hierarchical Linear Modelling. Neither selflicensing measures nor unhealthy snacking habits predicted unhealthy snack consumption. Daily stress was associated with lower unhealthy snack consumption. However, the interaction between daily stress and functional self-licensing was significant, suggesting that on stressful days functional self-licensers consume even fewer unhealthy snacks compared to less stressful days. Functional and dysfunctional self-licensing are rather new constructs which is why examining their effects is important for further research. However, in contrast to the existing evidence, we failed to find an effect of both types of self-licensing on snack consumption, suggesting the effect depends on potential contextual or individual-specific factors. Future research using a dieting sample is warranted for a better understanding of how functional and dysfunctional self-licensing operate.

Browse

Browsing PubMed İndeksli Yayınlar Koleksiyonu by browse.metadata.publisher "Academic Press Ltd- Elsevier Science Ltd"