PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12469/4466

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Citation - WoS: 2
Citation - Scopus: 3
3d-Printed Actuator-Based Beam-Steering Approach for Improved Physical Layer Security in Visible Light Communication
(Optica Publishing Group, 2022) Erdem, Mehmet Can; Gurcuoglu, Oguz; Panayırcı, Erdal; Kurt, Gunes Karabulut; Ferhanoglu, Onur
In this study, we present the design, manufacture, and implementation of a 3D-printed lens scanner-based beam steering for use in visible light communication (VLC) applications. The 5 cm x 5 cm scanner is designed for low-cost 3D printing with fused deposition modeling using polylactic acid. Scanning is facilitated through electromagnetic actuation of the lens frame, carrying a conventional 25 mm lens, from two nearly orthogonal directions. The serpentine spring that connects the lens frame to the external frame is tailored to offer similar spring constants in the directions of actuation and has minimal (<1.5 mm) sag due to the mass of the lens. The manufactured actuator was integrated on a miniaturized VLC test bed (70 cm x 40 cm x 40 cm). Using the test bed, we characterized the applied voltage versus beam displacement behavior of the actuator in the lateral plane and demonstrated beam steering on amoving target with face-recognition feedback. The proposed scheme was targeted to offer an improved security measure in VLC through tracking the legitimate receiver (i.e., via face recognition) and uses the feedback to steer the focused light onto the targeted device. The joint use of focusing and steering features allows for the legitimate receiver to roam within the room while enjoying the improved secrecy due to the focused light. We calculate the secrecy capacity for the demonstrated approach, which compares favorably with a number of jamming, spatial modulation, and beam-forming counterparts. The presented actuator can be used with larger room dimensions, yet upscaling to larger illumination units will require the use of a lens having smaller focus to address a larger total steering angle. (C) 2022 Optica Publishing Group
Citation - WoS: 5
Citation - Scopus: 7
Abortion Services at Hospitals in Istanbul
(Taylor & Francis Ltd, 2017) O'Neil, Mary Lou
Objective: Despite the existence of a liberal law on abortion in Turkey there is growing evidence that actually securing an abortion in Istanbul may prove difficult. This study aimed to determine whether or not state hospitals and private hospitals that accept state health insurance in Istanbul are providing abortion services and for what indications. Method: Between October and December 2015 a mystery patient telephone survey of 154 hospitals 43 public and 111 private in Istanbul was conducted. Results: 14% of the state hospitals in Istanbul perform abortions without restriction as to reason provided in the current law while 60% provide the service if there is a medical necessity. A quarter of state hospitals in Istanbul do not provide abortion services at all. 48.6% of private hospitals that accept the state health insurance also provide for abortion without restriction while 10% do not provide abortion services under any circumstances. Key conclusions: State and private hospitals in Istanbul are not providing abortion services to the full extent allowed under the law. The low numbers of state hospitals offering abortions without restriction indicates a de facto privatization of the service. This same trend is also visible in many private hospitals partnering with the state that do not provide abortion care. While many women may choose a private provider the lack of provision of abortion care at state hospitals and those private hospitals working with the state leaves women little option but to purchase these services from private providers at some times subtantial costs.
Citation - WoS: 23
Citation - Scopus: 26
Absolute Configuration and Biological Profile of Pyrazoline Enantiomers as Mao Inhibitory Activity
(Wiley, 2019) Goksen, Umut Salgin; Sarıgül, Sevgi; Bultinck, Patrick; Herrebout, Wouter; Doğan, İlknur; Yelekçi, Kemal; Uçar, Gülberk; Kelekçi, Nesrin Gökhan
A new racemic pyrazoline derivative was synthesized and resolved to its enantiomers using analytic and semipreparative high-pressure liquid chromatography. The absolute configuration of both fractions was established using vibrational circular dichroism. The in vitro monoamine oxidase (MAO) inhibitory profiles were evaluated for the racemate and both enantiomers separately for the two isoforms of the enzyme. The racemic compound and both enantiomers were found to inhibit hMAO-A selectively and competitively. In particular the R enantiomer was detected as an exceptionally potent and a selective MAO-A inhibitor (K-i = 0.85 x 10(-3) +/- 0.05 x 10(-3) mu M and SI: 2.35 x 10(-5)) whereas S was determined as poorer compound than R in terms of K-i and SI (0.184 +/- 0.007 and 0.001). The selectivity of the enantiomers was explained by molecular modeling docking studies based on the PDB enzymatic models of MAO isoforms.
Citation - WoS: 12
Citation - Scopus: 15
Acute Aortic Valve Regurgitation Secondary To Blunt Chest Trauma
(Texas Heart Inst., 2001) Ünal, Mehmet; Demirsoy, Ergun; Göğüş, Abdullah; Arbatlı, Harun; Hamzaoğlu, Azmi; Sönmez, Bingür
Blunt injury to the cardiac valves leads to progressive acute ventricular failure which often requires urgent surgical management In this case report we describe an acute aortic valve rupture caused by air-bag inflation during an automobile accident. Laceration of an aortic valve cusp was treated successfully with urgent aortic valve replacement. A concomitant orthopedic injury was treated electively 15 days after cardiac surgery. Acute aortic valve rupture is a very rare complication of blunt chest trauma. We discuss how to diagnose and manage this potentially catastrophic event.
Citation - WoS: 1
Citation - Scopus: 1
Analysis of the Patients and Physicians Connection Network on an Online Health Information Platform
(IOS Press, 2014) Aydın, Mehmet Nafiz; Perdahci, N. Ziya
Social network applications have gained popularity in the health domain as they bring health information seekers (patients and alike) and medication advice providers (physicians and other relevant actors) together. By employing a network science perspective this research is aimed to understand an information network establishing connections among and between information seekers and providers. We found that such a connection network surfaces most of the essential characteristics of a typical complex network. Furthermore a detailed structural analysis shows some intriguing relations and connection behaviours in the network. Implications of the findings are discussed from the perspectives of medical informatics and social network analysis.
Antibiyotikli kemik çimentosunun 0 ve 15. günlerde mekanik dayanımı: Surgical Simplex P kemik çimentosu ve teikoplanin ile biyomekanik çalışma
(Türk Ortopedi ve Travmatoloji Derneği, 2002) Göğüş, Abdullah; Akman, Şenol; Göksan, Bora S.; Bozdağ, Ergün
Amaç: Mekanik dayanım açısından 40 gr belirli bir kemik çimentosuna katılabilecek belirli bir antibiyotiğin maksimum dozu "0. gün" ve antibiyotik salınımı sonrası "15. gün" için araştırıldı. Çalışma planı: 40 g Surgical Simplex P kemik çimentosuna 0, 400, 800,1200,1600, 2000, 3200 ve 4000 mg teikoplanin katılarak sekiz deney grubu oluşturuldu. Kompresyon ve dört nokta eğme mekanik dayanım testleri için üçüncü kuşak sement hazırlama ve uygulama koşullarında örnekler elde edildi. Her bir konsantrasyon için "0. gün" ve "15. gün" için 10'ar örnek oluşturuldu. Örneklerin mekanik dayanım testleri ASTM ve ISO standartlarına göre "0. gün" ve 37∘ C su banyosunda antibiyotik salınımı sonrası "15. gün"de yapıldı. Değişik antibiyotik konsantrasyonları 0 mg kontrol grubu ile, ayrıca aynı antibiyotik konsantrasyonlarının 0. gün ve 15. gün mekanik test sonuçları karşılaştırıldı. Sonuçlar: Kompresyon testlerinde "0. gün" grubu içinde anlamlı farklılık bulunmadı; "15. gün" grubunda ise 800 mg'den itibaren anlamlı dayanım azalması saptandı. Her iki grupta tüm konsantrasyonlarda elde edilen mekanik dayanım değerleri ASTM alt limiti olan 70 MPa'nın üzerindeydi. Dört nokta eğme testinde "0. gün" grubunda 1200 mg'den itibaren, "15. gün" grubunda ise 400 mg'den itibaren anlamlı dayanım azalması saptandı. "15. gün" grubundan 4000 mg ISO'nun alt limiti olan 50 MPa'nın altında kalırken, 3200 ve 2000 mg gruplarında 50 MPa'ya çok yakın sonuçlar elde edildi. Çıkarımlar: Deney sonuçları, üçüncü kuşak çimento hazırlama ve uygulama koşullarında, 40 gr Surgical Simplex P kemik çimentosuna güvenle katılabilecek en yüksek teikoplanin dozunun 1600 mg olduğunu gösterdi.
Citation - WoS: 8
Citation - Scopus: 9
Antifungal Screening and in Silico Mechanistic Studies of an In-House Azole Library
(2019) Sarı, Suat; Kart, Didem; Sabuncuoğlu, Suna; Doğan, İnci Selin; Özdemir, Zeynep; Bozbey, İrem; Gencel, Melis; Eşsiz, Şebnem; Reynisson, Jóhannes; Karakurt, Arzu; Saraç, Selma; Dalkara, Sevim
Systemic Candida infections pose a serious public health problem with high morbidity and mortality. C. albicans is the major pathogen identified in candidiasis; however, non-albicans Candida spp. with antifungal resistance are now more prevalent. Azoles are first-choice antifungal drugs for candidiasis; however, they are ineffective for certain infections caused by the resistant strains. Azoles block ergosterol synthesis by inhibiting fungal CYP51, which leads to disruption of fungal membrane permeability. In this study, we screened for antifungal activity of an in-house azole library of 65 compounds to identify hit matter followed by a molecular modeling study for their CYP51 inhibition mechanism. Antifungal susceptibility tests against standard Candida spp. including C. albicans revealed derivatives 12 and 13 as highly active. Furthermore, they showed potent antibiofilm activity as well as neglectable cytotoxicity in a mouse fibroblast assay. According to molecular docking studies, 12 and 13 have the necessary binding characteristics for effective inhibition of CYP51. Finally, molecular dynamics simulations of the C. albicans CYP51 (CACYP51) homology model's catalytic site complexed with 13 were stable demonstrating excellent binding.
Citation - WoS: 8
Citation - Scopus: 9
Apolipoprotein B Gene Variants Are Involved in the Determination of Blood Glucose and Lipid Levels in Patients With Non-Insulin Dependent Diabetes Mellitus
(Wiley, 2006) Duman, Belgin Süsleyici; Öztürk, Melek; Yilmazer, Selma; Çağatay, Penbe; Hatemi, Hüsrev
We have examined the frequency of the EcoRI XbaI and MspI RFLPs of the apolipoprotein B (apo 13) gene in I 10 type 2 diabetic patients and 9 1 healthy control subjects in order to ascertain whether variation in this gene may influence the development of non-insulin dependent diabetes mellitus (type 2 diabetes). Serum lipids including total-cholesterol (T-Chol) triacylglycerol (TAG) apolipoprotein E (apo E) apolipoprotein Al (apo Al) apolipoprotein B and lipoprotein (a) (Lp(a)) were analysed. Genomic DNA was extracted and the apo B polymorphic regions amplified by the polymerase chain reaction. Regions carrying EcoRI XbaI and MspI restriction sites present in the apo B gene were amplified and digested separately by the respective enzymes. No significant difference for genotypic frequencies was observed for the EcoRI XbaI and MspI restriction sites in type 2 diabetic patients as compared to controls. Type 2 diabetic patients and controls with EcoRI +/+ and XbaI +/+ genotypes had higher apo E levels. The MspI +/+ genotype is more frequent in the patient and control groups With elevated T-Chol. Furthermore the EcoRI -/- XbaI -/- and MspI +/+ genotypes were found to be significantly more frequent in type 2 diabetic patients with higher blood glucose levels. This study identifies the apo B gene polymorphisms in modulating plasma lipid/lipoprotein and glucose levels in patients with type 2 diabetes. Copyright 0 2005 John Wiley & Sons Ltd.
Citation - WoS: 1
The association of HLA-DRB1 alleles and MBL2 gene variant in pediatric acute lymphoblastic leukemia patients
(Elsevier, 2024) Oguz, Rustu; Ciftci, Hayriye Senturk; Gokce, Muge; Ogret, Yeliz; Karadeniz, Sedat; Pehlivan, Sacide; Ayd, Filiz
Introduction: Epidemio logic studies on pediatric acute lymphoblastic leukemias (ALL) have been conducted to evaluate the possible risk factors including genetic, infectious and environmental factors with the objective of idenfying the etiology. Mannose-binding lectin 2 (MBL2) plays an important role in first-line immune defense. HLA DRB1 alleles play a role in presentation of peptides to T cells and in activation of the adaptive immune response. Objective: In our study, we aimed to investigate both the MBL2 gene variant and HLA-DRB1 alleles in pediatric ALL patients. Materials: In this study, 86 high-risk ALL patients and 100 controls were included. Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (PCR-RFLP) and PCRsequence specific primer (SSP) methods were used for detection of polymorphism of the MBL2 and HLA-DRB1 alleles, respectively. Results: The frequency of the MBL2 AB genotype was lower in female ALL patients, compared to male ALL patients (p = 0.034). An association was found between the MBL2 BB genotype and DRB1*07 and among patients with the MBL2 BB genotype; those who also carried the DRB1*07 and *04 alleles were significantly higher than those without the DRB1*07 and *04 alleles. (p = 0.048, p = 0.022, respectively). Conclusion: This is the first study suggesting that the MBL2 BB genotype in association with the DRB1*07 or co-inheritance of the HLA-DRB1*04 and HLA DRB1*07 may have an impact on the etiopathogenesis of the disease. (c) 2023 Associa & ccedil;& atilde;o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Attentional Modulation of Outlier Processing
(Springer, 2025) Gokce, Ahu; Yildirim, Bugay; Boduroglu, Aysecan
Ensemble perception enables the visual system to function effectively when the number of stimuli in the environment exceeds its capacity. Ensemble representations not only help the limited capacity of visual representations, but they also facilitate the detection and representation of items deviating from the group (i.e., the outlier). This study focuses on how attentional mechanisms modulate outlier processing. In three experiments, we presented participants with an ensemble that was formed by circle stimuli in varying sizes, and the outlier item was distinct in terms of its location. We measured outlier localization performance while manipulating attentional orienting via a spatial cueing paradigm. In Experiment 1, a valid, invalid, or neutral cue was presented before or after the display. Facilitation of outlier localization was most pronounced in the valid precue condition. Experiment 2 included a task to actively engage ensemble perception in addition to outlier localization, and cue validity effect was observed as in Experiment 1. Experiment 3A was carried to directly compare the top-down and bottom-up influences on outlier processing by presenting two spatial outliers-one target and another distractor outlier. The target outlier identity was previously determined and was identical across trials. In Experiment 3B, the target was in red, making it salient among the remaining items. In the invalid trials, where the distractor outlier was cued, responses were closer to the distractor item indicating that outlier processing is cue driven. These experiments overall demonstrate that automaticity of outlier processing can be overridden by cue-driven processes.
Attractiveness Differentially Affects Direct Versus Indirect Face Evaluations in Two Cultures
(Sage Publications Inc, 2023) Cassidy, Brittany S.; Saribay, S. Adil; Yuksel, Huseyin; Kleisner, Karel
Although decades of research have identified facial features relating to people's evaluations of faces, specific features have largely been examined in isolation from each other. Recent work shows that considering the relative importance of these features in face evaluations is important to test theoretical assumptions of impression formation. Here, we examined how two facial features of evolutionary interest, facial attractiveness and facial-width-to-height ratio (FWHR), relate to evaluations of faces across two cultures. Because face evaluations are typically directly measured via self-reports, we also examined whether these features exert differential effects on both direct and indirect face evaluations. Evaluations of standardized photos naturally varying in facial attractiveness and FWHR were collected using the Affect Misattribution Procedure in the United States and Turkey. When their relative contributions were considered in the same model, facial attractiveness, but not FWHR, related to face evaluations across cultures. This positive attractiveness effect was stronger for direct versus indirect evaluations across cultures. These findings highlight the importance of considering the relative contributions of facial features to evaluations across cultures and suggest a culturally invariant role of attractiveness when intentionally evaluating faces.
Citation - WoS: 4
Citation - Scopus: 4
Augmentation Mentoplasty Using a Custom-Design Wire Cage
(Lippincott Williams & Wilkins, 2003) Erol ,O.; Enacar, A.
Mentoplasty is often a complimentary procedure to rhinoplasty. At least 25% of all rhinoplasty patients may need a chin implant to balance facial features better. Augmentation mentoplasty using alloplastic implants such as silicone rubber or other materials provides a simple approach to the treatment of the hypoplastic chin. Although these types of implants are readily available in developed countries there are parts of the world where they are unavailable or quite expensive. The authors have developed a chin implant made of wire that is available throughout the world and is custom designed to the mentum of the patient after a cephalometric evaluation. This technique has been used in 125 patients along with rhinoplasty over the last 20 years at our institution. In an initial series of 8 patients the prosthesis became displaced and was removed in 2 patients. Since then a new radiographic technique has been developed to demonstrate the shape of the mentum before surgery and new bone formation after surgery. By using this special radiographic technique it was possible to detect four types of mentum before surgery and to construct a custom-design wire cage according to this shape. The prosthesis is constructed by an orthodontist according to the cephalometric measurements and shape of the mentum. By using the buccal approach a pocket is prepared subperiosteally and a wire cage is inserted. In the last 20 cases the wire cage was filled with diced cartilage wrapped with Surgicel. The results were esthetically satisfactory in most patients. After the shape of the wire prosthesis was modified to conform to the shape of the underlying bone better no displacement of the prosthesis has been experienced. In 3 patients it was necessary to remove the prosthesis when new tissue formation began to fill the prosthesis. These specimens were examined histologically and the regenerating tissue was found to be connective tissue with a thin layer of bone formation. Most patients could be followed up for only 3 to 12 years. In all patients the results have been consistent and the procedure has been safe.
Citation - WoS: 3
Citation - Scopus: 3
Beliefs of Living Donors About Recipients' End-Stage Liver Failure and Surgery for Organ Donation
(Elsevier Science Inc, 2017) Krespi-Boothby, Margörit Rita; Tankurt, A.; Acarli, Koray; Kanmaz, Turan; Yankol, Yucel; Kalayoğlu, Murat
Background. The concept of beliefs could provide a basis for how donors may perceive recipients' end-stage liver failure (ESLF) and surgery for organ donation. However there is no such quantitative study. Therefore the objective of this study was to explore beliefs of living donors about recipients' ESLF and surgery for organ donation. Methods. The sample comprised 16 living donors who donated a part of their liver to a patient who had ESLF. The data were analyzed by following established procedures for inductive qualitative analysis. Results. Analysis showed that donors' beliefs can be viewed in a number of groups. Beliefs about recipients' ESLF included diverse explanations for ESLF (blaming oneself and physicians) and physical symptoms (developmental slowing down). Beliefs about being a donor included reasons for being a donor (performing a good deed being healed) barriers to being a donor (other people being ignorant and selfish) ways to manage these barriers (following one's gut feeling) and factors facilitating being a donor (the feeling that one does not have many people to leave behind). Beliefs about surgery for organ donation included physical effects (pain feeling stiff). Beliefs about organ donation included views that general organ donation should be encouraged and that people's awareness should be raised. Conclusions. Existing psychological perspectives could help to interpret some beliefs. Nevertheless other beliefs not previously reported could be considered as targets for individual consultations/psycho-educational programs for fostering emotional well-being.
Citation - WoS: 18
Citation - Scopus: 19
Carboxylic Acid Derivatives Display Potential Selectivity for Human Histone Deacetylase 6: Structure-Based Virtual Screening Molecular Docking and Dynamics Simulation Studies
(Elsevier Science, 2018) Uba, Abdullahi Ibrahim; Yelekçi, Kemal
Human histone deacetylase 6 (HDAC6) has been shown to play a major role in oncogenic cell transformation via deacetylation of alpha-tubulin making it a viable target of anticancer drug design and development. The crystal structure of HDAC6 catalytic domain 2 has been recently made available providing avenues for structure-based drug design campaign. Here in our continuous effort to identify potentially selective HDAC6 inhibitors structure-based virtual screening of similar to 72 461 compounds was carried out using Autodock Vina. The top 100 compounds with calculated Delta G < -10 kcal/mol were manually inspected for binding mode orientation. Furthermore the top 20 compounds with reasonable binding modes were evaluated for selectivity by further docking against HDAC6 and HDAC7 using Autodock4. Four compounds with a carboxylic fragment displayed potential selectivity for HDAC6 over HDAC7 and were found to have good druglike and ADMET properties. Their docking complexes were then submitted to 10 ns-molecular dynamics (MD) simulation using nanoscale MD (NAMD) software to examine the stability of ligand binding modes. These predicted inhibitors remained bound to HDAC6 in the presence of water and ions and the root-mean-square deviation (RMSD) radius of gyration (Rg) and nonbond distance (protein-ligand) profiles suggested that they might be stable over time of the simulation. This study may provide scaffolds for further lead optimization towards the design of HDAC6 inhibitors with improved selectivity. (C) 2018 Elsevier Ltd. All rights reserved.
Citation - WoS: 17
Citation - Scopus: 16
Cation Effect on Slow Release From Alginate Beads: a Fluorescence Study
(Springer/Plenum Publishers, 2014) Kaygusuz, Hakan; Erim, F. Bedia; Pekcan, Önder; Evingür, Gülşen Akin
In this study spherical alginate beads containing pyranine (P-y) as a fluorescence probe were prepared by ionotropic gelation of a sodium alginate solution. The steady state fluorescence technique was used to study pyranine release from the alginate beads crosslinked with calcium barium and aluminum ions respectively. The slow release of P-y was observed with the time drive mode of the spectrophotometer at 512 nm. Fluorescence emission intensity (I-p) from P-y was monitored during the release process and the encapsulation efficiency (EE) of pyranine from the alginate beads was calculated. The Fickian Diffusion model was used to measure the release coefficients D-sl. It was seen that the slow release coefficients of pyranine from the alginate beads crosslinked with Ca2+ Ba2+ and Al3+ ions increased in the following order: D-sl (Al3+)> D-sl (Ca2+)> D-sl (Ba2+). In contrast the initial amount of pyranine and EE into the beads showed the reverse behavior.
Citation - WoS: 11
Citation - Scopus: 11
Cervical Radiculopathy Caused by Vertebral Artery Loop Formation - Multislice Computed Tomography Angiography Findings
(Lippincott Williams & Wilkins, 2005) Ganiyusufoğlu, A. Kursad; Kantarcı, Mecit; Şırvancı, Mustafa; Sildiroglu, Onur; Alparslan, L.
Vertebral artery tortuosity and loop formation are rare causes of cervical radiculopathy. The criterion standard for the detection of vertebral artery loop formation is digital subtraction angiography. Computed tomography (CT) and magnetic resonance imaging provide good accuracy in the evaluation of vertebral arteries. A case of vertebral artery loop formation is reported. The diagnosis was confirmed by 16-row multisection CT angiography findings of vertebral artery loop formation.
Citation - Scopus: 1
Cervical Spine Injuries in Children
(2004) Hamzaoglu, A.; Mirzanli, C.
Cervical spine injuries in children and adolescents are rare. Common mechanisms include motor vehicle accidents, sports injuries, fall from height, and gunshot injuries. Cervical spine injuries are classified by Allen and Ferguson according to the period they occur, as infantile, early juvenile, and late juvenile. Anatomically, two main types are defined as occipitoatlantal (upper cervical) and subaxial injuries. The purpose of this paper is to review cervical spine injuries in children and adolescents with respect to epidemiology, injury mechanisms, diagnosis, clinical and radiologic aspects, and treatment in the light of the current literature.
Citation - WoS: 47
Citation - Scopus: 56
Comparison of Five Antimicrobial Regimens for the Treatment of Brucellar Spondylitis: a Prospective, Randomized Study
(E I F T Srl, 2003) Bayindir, Y; Sonmez, E; Aladag, A; Buyukberber, N
Brucellosis, a zoonosis with worldwide distribution, is a systemic infection and still an important public health problem in Turkey. The best antimicrobial combination and schedule for the treatment of brucellosis with spondylitis has not yet been clearly determined. In a prospective and randomized study, we compared the efficacy of five antimicrobial regimens for treatment of 102 patients with lumbar brucellar spondylitis. Patients were randomly assigned to receive antimicrobial combination therapy. Twenty patients received streptomycin 1 g/day intramuscularly for 15 days and tetracycline-HCl, 500 mg every 6 h orally for 45 days (ST), 21 patients received streptomycin 1 g/day i.m. for 15 days and doxycycline 100 mg every 12 h orally for 45 days (SD), 20 patients received doxycycline 100 mg every 12 h orally for 45 days and rifampicin 15 mg/kg per day in a single morning dose orally for 45 days (DR), 19 patients received ofloxacin, 200 mg every 12 h orally for 45 days and rifampicin 15 mg/kg per day in a single morning dose orally for 45 days (OR), and 22 patients received streptomycin 1 g/day i.m. for 15 days and doxycycline 100 mg every 12 h orally for 45 days plus rifampicin 15 mg/kg per day in a single morning dose orally for 45 days (SDR). Initial therapeutic failure occurred in 2 patients (10%) in the ST regimen group, 4 patients (19%) in the SD group, 3 patients (15%) in the DR group and 5 patients (26%) in the OR regimen. In addition, 2 patients (10%) in the DR group and 5 patients (26%) in the OR regimen relapsed during the follow-up period. There was no relapse in any patients in the ST, SD, and SDR groups. The response rates were 90% in the ST and 81% in the SD groups. In contrast, there was a maximum good response (100%) and no relapse in the SDR group. In conclusion, a combination of doxycycline, streptomycin, and rifampicin can be recommended as therapy for brucellar spondylitis and to reduce relapse rates.
Citation - WoS: 9
Comparison of Intraoperative Transit-Time Flow Measurement With Early Postoperative Magnetic Resonance Flow Mapping - in Off-Pump Coronary Artery Surgery
(Texas Heart Inst., 2003) Sanisoğlu, İlhan; Güden, Mustafa; BalcI, Cem; SaĞbaŞ, Ertan; Duran, Cihan; AkpInar, Belhhan
The purpose of this prospective study was to evaluate graft patency of off-pump coronary artery surgery intraoperatively by transit-time flow measurement and to compare this technique with postoperative magnetic resonance flow mapping. Twenty patients (13 men and 7 women
Citation - WoS: 6
Citation - Scopus: 7
Comparison of the BBL-mycobacteria growth indicator tube method with culture in the diagnosis of tuberculosis and evaluation of the resistance patterns of isolated strains to four major drugs
(Karger, 2002) Kocazeybek, Bekir Sami
The BBL-mycobacteria growth indicator tube system (MGIT) is used for a rapid detection of the presence of mycobacteria. Our study aimed to compare MGIT with the Lowenstein-Jensen (LJ) reference method in clinical samples with suspected pulmonary and extrapulmonary tuberculosis and to evaluate the primary and secondary resistance patterns by determining the resistances of the isolated strains to four major anti mycobacteria I drugs. 648 clinical samples from different clinics with suspected pulmonary or extrapulmonary tuberculosis based on clinical radiological histopathological and immunological findings were included in the investigation. The samples were first stained with Ziehl-Neelsen (ZN) and then cultured in LJ medium according to the standard bacteriological procedure and in the MGIT as recommended by the manufacturer. Conventional biochemical tests and p-nitro-alpha-acethylamino-beta-hydroxypropiophene of the Bactec system were used to identify the isolated mycobacterial strains. The susceptibilities to streptomycin isoniazid rifampicin ethambutol were tested by the BBL-MGIT antibiotic susceptibility test and the resistances of the strains found to be resistant to any of the drugs were confirmed by the agar proportion method. Mycobacterium spp. were isolated in 61 (9.4%) out of 648 samples. Eventually 58 out of 61 strains were classified as Mycobacterium tuberculosis and the other 3 as Mycobacterium tuberculosis complex. 32 of these were ZN positive. The growth time was determined as 12.2 days by the MGIT method and 24.1 days by the LJ method (p < 0.001). 29 strains were ZN negative. Their growth time was 23 days by the MGIT method and 37 days by the LJ method (p < 0.001). Drug resistance was detected in 23 (37.7%) of 61 cases (of whom 39 were new and 22 were former patients)

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