PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://gcris.khas.edu.tr/handle/20.500.12469/4466

Browse

Now showing 1 - 20 of 25

Citation - WoS: 6
Citation - Scopus: 5
The acquisition and use of relative clauses in Turkish-learning children's conversational interactions: a cross-linguistic approach
(Cambridge University Press, 2019) Arslan Uzundağ, Berna; Küntay, Aylin C.
Using a cross-linguistic approach, we investigated Turkish-speaking children's acquisition and use of relative clauses (RCs) by examining longitudinal child-caregiver interactions and cross-sectional peer conversations. Longitudinal data were collected from 8 children between the ages of 8 and 36 months. Peer conversational corpus came from 78 children aged between 43 and 64 months. Children produced RCs later than in English (Diessel, 2004) and Mandarin (Chen & Shirai, 2015), and demonstrated increasing semantic and structural complexity with age. Despite the morphosyntactic difficulty of object RCs, and prior experimental findings showing a subject RC advantage, preschool-aged children produced object RCs, which were highly frequent in child-directed speech, as frequently as subject RCs. Object RCs in spontaneous speech were semantically less demanding (with pronominal subjects and inanimate head nouns) than the stimuli used in prior experiments. Results suggest that multiple factors such as input frequency and morphosyntactic and semantic difficulty affect the acquisition patterns.
Citation - WoS: 79
Citation - Scopus: 95
The association of the severity of obstructive sleep apnea with plasma leptin levels
(Amer Medical Assoc., 2003) Öztürk, Levent; Ünal, Murat; Tamer, Lülüfer; Çelikoğlu, Firuz
Objective: To examine whether circulating leptin levels correlate with the severity of disease in patients with obstructive sleep apnea. Design: Prospective nonrandomized study. Setting: Referral sleep laboratory for patients with sleep-disordered breathing and biochemistry laboratory. Patients: Thirty-two subjects (mean+/-SD age 47+/-12 years) who were referred for suspected sleep apnea underwent an overnight sleep study and fasting morning venous blood sampling. Patients were divided into 3 groups with respect to apnea-hypopnea index: (1) severe sleep apnea (n=8) apnea-hypopnea index greater than 20
Citation - WoS: 106
Citation - Scopus: 126
Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials
(Elsevier Science Bv, 2002) Hanagasi, Hasmet A.; Gurvit, I. Hakan; Ermutlu, Numan; Kaptanoğlu, Gulustu; Karamürsel, Sacit; Idrisoğlu, Halil A.; Emre, Murat; Demiralp, Tamer
The presence of subclinical cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) is investigated using neuropsychological assessment and event-related potential recordings (ERP). An extensive battery of neuropsychological tests assessing the domains of attention memory language visuo-spatial and executive functions were administered to 20 non-demented patients with sporadic ALS and 13 age- and education-matched healthy control subjects. Mismatch negativity (MMN) P3b P3a (novelty P300) and contingent negative variation (CNV) were recorded. ALS patients were significantly impaired in tests of working memory sustained attention response inhibition naming verbal fluency and complex visuo-spatial processing. The memory impairment seemed to be secondary to deficits in forming learning strategies and retrieval. In ERP recordings P3a and P3b amplitudes of ALS patients were lower compared with the controls P3a latencies were significantly longer and mean CNV amplitudes were higher. These results indicate subclinical impairment of cognitive functions in patients with ALS. The pattern of cognitive impairment suggests the dysfunction of the frontal network. (C) 2002 Elsevier Science B.V. All rights reserved.
Citation - WoS: 6
Citation - Scopus: 7
Comparison of the BBL-mycobacteria growth indicator tube method with culture in the diagnosis of tuberculosis and evaluation of the resistance patterns of isolated strains to four major drugs
(Karger, 2002) Kocazeybek, Bekir Sami
The BBL-mycobacteria growth indicator tube system (MGIT) is used for a rapid detection of the presence of mycobacteria. Our study aimed to compare MGIT with the Lowenstein-Jensen (LJ) reference method in clinical samples with suspected pulmonary and extrapulmonary tuberculosis and to evaluate the primary and secondary resistance patterns by determining the resistances of the isolated strains to four major anti mycobacteria I drugs. 648 clinical samples from different clinics with suspected pulmonary or extrapulmonary tuberculosis based on clinical radiological histopathological and immunological findings were included in the investigation. The samples were first stained with Ziehl-Neelsen (ZN) and then cultured in LJ medium according to the standard bacteriological procedure and in the MGIT as recommended by the manufacturer. Conventional biochemical tests and p-nitro-alpha-acethylamino-beta-hydroxypropiophene of the Bactec system were used to identify the isolated mycobacterial strains. The susceptibilities to streptomycin isoniazid rifampicin ethambutol were tested by the BBL-MGIT antibiotic susceptibility test and the resistances of the strains found to be resistant to any of the drugs were confirmed by the agar proportion method. Mycobacterium spp. were isolated in 61 (9.4%) out of 648 samples. Eventually 58 out of 61 strains were classified as Mycobacterium tuberculosis and the other 3 as Mycobacterium tuberculosis complex. 32 of these were ZN positive. The growth time was determined as 12.2 days by the MGIT method and 24.1 days by the LJ method (p < 0.001). 29 strains were ZN negative. Their growth time was 23 days by the MGIT method and 37 days by the LJ method (p < 0.001). Drug resistance was detected in 23 (37.7%) of 61 cases (of whom 39 were new and 22 were former patients)
Citation - WoS: 2
Citation - Scopus: 2
Correlated conformational dynamics of the human GluN1-GluN2A type N-methyl-D-aspartate (NMDA) receptor
(SPRINGER, 2021) Eşsiz, Şebnem; Servili, Burak; Aktolun, Muhammed; Demir, Ayhan; Carpenter, Timothy S.; Servili, Burak
N-Methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels found in the nerve cell membranes. As a result of overexcitation of NMDARs, neuronal death occurs and may lead to diseases such as epilepsy, stroke, Alzheimer's disease, and Parkinson's disease. In this study, human GluN1- GluN2A type NMDAR structure is modeled based on the X-ray structure of the Xenopus laevis template and missing loops are added by ab-initio loop modeling. The final structure is chosen according to two different model assessment scores. To be able to observe the structural changes upon ligand binding, glycine and glutamate molecules are docked into the corresponding binding sites of the receptor. Subsequently, molecular dynamics simulations of 1.3 mu s are performed for both apo and ligand-bound structures. Structural parameters, which have been considered to show functionally important changes in previous NMDAR studies, are monitored as conformational rulers to understand the dynamics of the conformational changes. Moreover, principal component analysis (PCA) is performed for the equilibrated part of the simulations. From these analyses, the differences in between apo and ligand-bound simulations can be summarized as the following: The girdle right at the beginning of the pore loop, which connects M2 and M3 helices of the ion channel, partially opens. Ligands act like an adhesive for the ligand-binding domain (LBD) by keeping the bi-lobed structure together and consequently this is reflected to the overall dynamics of the protein as an increased correlation of the LBD with especially the amino-terminal domain (ATD) of the protein.
Citation - WoS: 8
Citation - Scopus: 11
Does off-pump coronary artery bypass surgery reduce mortality in high risk patients?
(Forum Multimedia Publishing LLC., 2001) Akpınar, Belhhan; Güden, Mustafa; Sanisoğlu, İlhan; Sağbaş, Ertan; Caynak, Barış; Bayramoğlu, Zehra; Bayındır, Osman
Background: The aim of this retrospective study was to compare outcome in two groups of patients who were classified according to their risk groups and underwent coronary revascularization with or without cardiopulmonary bypass. Material and Methods: Between January 1996 and July 2000 480 cases that underwent coronary artery bypass surgery (CABG) were included in a retrospective nonrandomized manner for study. Group I included 210 patients who were revascularized using off-pump techniques. Octopus 2 and 3 (Medtronic Inc. Minneapolis MN) were used for tissue stabilization. Group 2 included 270 cases who underwent CABG using CPB. Emergency cases combined operations reoperations and patients in cardiogenic shock were excluded. Demographic variables were comparable between two the groups. Using the Allegheny Clinic Risk Scoring Scale [Magovern 1996] patients in both groups were scored as low moderate and high risk. In Group 1 37% of patients consisted of high risk patients while Group 2 had 14% (p < 0.05) Student's t-test and chi-square test were used for statistical analysis and alfa < 0.05 was considered significant. Results: Mortality was 1.4% in Group 1 and 1.5% in Group 2 (p = ns). Mean anastomosis per patient was 2.6 +/- 0.6 in Group 1 and 3.2 +/- 0.5 in Group 2 (p < 0.05). Patients in Group I needed less blood transfusions and less inotropic support postoperatively (p < 0.05). There were also fewer minor neurological events (p < 0.05) and pulmonary complications (Type 2) in Group 1. Atrial fibrillation rate infection and major neurological deficit (Type 1) were similar in both groups. Mortality was less among Group 1 high risk patients (3.9%) in comparison to Group 2 high risk patients (7.9%) but this did not reach statistical significance. Conclusions: In low or moderate risk patients CABG can be performed safely with or without CPB. In high risk patients with several comorbidities off-pump CABG seems to be a safe and efficient method that can improve outcome.
Citation - WoS: 32
Citation - Scopus: 37
Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation
(Arnold Hodder Headline Plc., 1999) Yılmaz, Mert; Ener, Serdar; Akalın, Halis; Sağdıç, Kadir; Serdar, O. Akin; Cengiz, Mete
The systemic inflammatory response to cardiopulmonary bypass (CPB) is associated with increased production of cytokines. This systemic inflammatory response characterized by the activation of interleukin-6 (IL-6) and interleukin-8 (IL-8) during and after CPB is well documented. A prospective randomized double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (MPSS) on the circulating levels of serum cytokines and clinical outcome. Twenty patients were randomly divided into two groups on the basis of the administration of low-dose(1 mg/kg) MPSS in = 10) and placebo in = 10) into the pump prime solution. All patients were scheduled to undergo a primary
Citation - WoS: 0
Citation - Scopus: 0
Enhancing portfolio management using artificial intelligence: literature review
(Frontiers Media Sa, 2024) Sutiene, Kristina; Schwendner, Peter; Sipos, Ciprian; Lorenzo, Luis; Mirchev, Miroslav; Lameski, Petre; Cerneviciene, Jurgita
Building an investment portfolio is a problem that numerous researchers have addressed for many years. The key goal has always been to balance risk and reward by optimally allocating assets such as stocks, bonds, and cash. In general, the portfolio management process is based on three steps: planning, execution, and feedback, each of which has its objectives and methods to be employed. Starting from Markowitz's mean-variance portfolio theory, different frameworks have been widely accepted, which considerably renewed how asset allocation is being solved. Recent advances in artificial intelligence provide methodological and technological capabilities to solve highly complex problems, and investment portfolio is no exception. For this reason, the paper reviews the current state-of-the-art approaches by answering the core question of how artificial intelligence is transforming portfolio management steps. Moreover, as the use of artificial intelligence in finance is challenged by transparency, fairness and explainability requirements, the case study of post-hoc explanations for asset allocation is demonstrated. Finally, we discuss recent regulatory developments in the European investment business and highlight specific aspects of this business where explainable artificial intelligence could advance transparency of the investment process.
Citation - WoS: 3
Citation - Scopus: 4
The evaluation of microbial contamination in platelet concentrates prepared by two different methods
(Pergamon-Elsevier Science Ltd, 2001) Kocazeybek, Bekir Sami; Arabaci, Ümit; Akdur, Hülya; Sezgic, Metin; Erentürk, Selim
The microbial contamination of platelet concentrates (PCs) prepared by two different methods both with a high risk of bacterial contamination during preparation and storage were evaluated. For apheresis platelets the concentrates were obtained using the Haemonetics MCS 3P device. For the random method platelets were obtained by two phase centrifugation in the Heraeus Cryofuge 8500 I device using the Kansuk 3-way bags which permit storage for five days. 1620 platelet pheresis units prepared by apheresis and 9838 units prepared by the random method were included in the study. Of the 11458 PCs studied 32 (0.27%) were false positives and 24 (0.2%) were real positives. All of the positive results occurred in platelets prepared by the random method. C. xerosis and S. epidermidis S. hominis Alpha-hemolytic streptococci all flora of the skin were isolated in the contaminated concentrates. The risk of microbial contamination of PCs prepared both by apheresis and from whole blood continues at a low rate although the products were collected into specific bags following rules including appropriate disinfection of the skin correct centrifugation collection time and optimal storage conditions including temperature and agitation. These results again emphasize the importance of. obeying phlebotomy rules and hand disinfection of the person who collects the blood as well as the need for careful skin decontamination of the donor during donation. (C) 2001 Elsevier Science Ltd. All rights reserved.
Citation - Scopus: 3
Evaluation of the Potential Therapeutic Properties of Liquidambar orientalis Oil
(John Wiley and Sons Inc, 2023) Cengiz Baloglu, M.; Yildiz, Ozer, L.; Pirci, B.; Zengin, G.; Ibrahim, Uba, A.; Celik, Altunoglu, Y.
Liquidambar orientalis Mill., commonly called the Anatolian sweetgum or Sigla tree, is endemic to southwestern Turkey. It has been historically significant in traditional medicine. In our research, we delved into the therapeutic attributes of its oil, emphasizing its antioxidant, antimicrobial, and antitumor properties. The primary chemical constituent of the gum is styrene, accounting for 78.5 %. The gum demonstrated antioxidant capabilities in several assays, including in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2?-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP). It displayed bactericidal actions against various gram-positive bacteria, such as Staphylococcus aureus, and gram-negative strains, including Escherichia coli. Additionally, the oil showcased potent antitumor effects against breast (MDA-MB-231), lung (A549), and prostate (PC3) cancer cell lines. These effects were found to be both time- and dose-dependent. L. orientalis Mill. oil showed the best antitumor activity against breast, lung, and prostate cancer cell lines after the 24 h and 48 h treatment. Its oil might induce autophagy in the PC3 prostate cancer cell line, whereas its cytotoxicity against MDA-MB-231 and A549 cancer cell lines might not be correlated with autophagy or apoptosis pathways. In conclusion, the oil from the Sigla tree offers promising therapeutic potential and warrants further exploration. © 2023 Wiley-VHCA AG, Zurich, Switzerland.
Citation - Scopus: 1
The fragile point of cardiac rehabilitation: Exercise compliance (The effects of phase II cardiac rehabilitation programme on patients undergone coronary bypass surgery) (multiple letters)
(2005) Kaşikcioğlu, E.; Çiftci, Ç.
[No abstract available]
Citation - WoS: 16
Citation - Scopus: 18
General anesthesia with thoracic epidural anesthesia in the cardiopulmonary bypass surgery reduces apoptosis by upregulating antiapoptotic protein Bcl-2
(Edizioni Minerva Medica, 2006) Kılıçkan, Levent; Gonca, Süheyla; Dalcık, C.; Dalcık, H.; Solak, M.; Bayındır, Osman; Suezer, K.; Omay, O.; Kan, E. Cali
Aim. The aim of the paper was to investigate whether thoracic epidural anesthesia (TEA) together with general anaesthesia (GA) play a role on apoptosis in humans before cardiopulmonary bypass (CPB) before aortic cross clamp (ACC) and at 15 min after ACC release (after ischemia and reperfusion). Methods. Eighty patients scheduled for elective CABG were randomized to receive either GA group (n: 40) or TEA+GA group (n: 40). The right atrial biopsy samples were taken before CPB before ACC and at 15 min after ACC release from all patients. Human heart tissues were obtained from patients of TEA+GA group and GA group. The number of Bcl-2 positive cardiomyocytes was counted in multiple tissue sections of biopsies of 80 patients using fight microscopy (magnification X 40) with an ocular micrometer system (Olympus). Results. In the TEA+GA group the Bcl-2 positive cardiomyocytes were distinctly statistically increased compared to the GA group (P<0.001). in addition the intensity of the immunostaining was also increased in the TEA+GA compared with the GA group. The number of immunoreactive cardiomyocytes is as follows: before CPB TEA+GA group 396 61 GA group 92 41 before ACC TEA+GA group 333 47 GA group 94 18 at 15 min after ACC release TEA+GA group 346 +/- 68.8 GA group 85 +/- 9.5. There were statistically significant differences between groups (P<0.001). Between groups at 4 h and at 24 h after the end of CPB in the TEA+GA group the Cl was significantly higher than GA group respectively
Citation - WoS: 17
Citation - Scopus: 16
Hyperuricemia in hypothyroidism: Is it associated with post-insulin infusion glycemic response?
(Tohoku Univ Medical Press, 2003) Dariyerli, Nuran; Andican, Gülnur; Çatakoğlu, Alp Burak; Hatemi, Hüsrev; Burçak, Gülden
This experimental study was designed to examine whether hyperuricemia in hypothyroidism is associated with insulin resistance. For induction of hypothyroidism rabbits (n = 12) were administered methimazole orally (75 mg/100 g food) for 30 days. T-3 T-4 and TSH values measured in plasma prior to and at the end of the experimentation period revealed the establishment of hypothyroidism. In the euthyroid and hypothyroid states of rabbits crystalline porcine insulin was administered (0.1 unit/kg body weight) intraperitoneally and plasma glucose was measured at 0 15 30 45 and 60 minutes. Sum of post insulin infusion glucose values was considered to reflect insulin resistance. Creatinine clearance (GFR) and uric acid clearance (C-uA) were determined. Additionally triglycerides were measured in plasma and Mg2+ both in erythrocytes and in plasma. Due to hypothyroidism: i) The glycemic response to insulin was not altered. ii) GFR and C-uA were both decreased but C-uA/GFR unchanged. iii) Triglycerides in plasma decreased. iv) Mg2+ concentration increased in plasma whereas decreased in erythrocytes. Several associations were observed between the variables on correlation analysis. On the basis of our data it could be suggested that insulin resistance does not exist in hypothyroidism. Hyperuricemia observed in hypothyroidism should be considered to be secondary to decreased renal excretion but not as an indicator of insulin resistance. (C) 2003 Tohoku University Medical Press.
Citation - WoS: 15
Citation - Scopus: 17
An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications
(Mdpi, 2022) Kurt-Celep, Inci; Zheleva-Dimitrova, Dimitrina; Gevrenova, Reneta; Uba, Abdullahi Ibrahim; Zengin, Gokhan; Yildiztugay, Evren; Picot-Allain, Carene Marie Nancy
The biological activity of the aerial part and rhizomes of Primula auriculata were assessed for the first time. The biological activities (antioxidant properties, enzyme inhibition, and AGE inhibition) as well as the phenolic and flavonoid contents of the ethyl acetate, ethanol, hydro-ethanol and water extracts of P. auriculata aerial parts and rhizomes were determined. Cell viability assays and gelatin zymography were also performed for MMP-2/-9 to determine the molecular mechanisms of action. The gene expression for MMPs was described with RT-PCR. The levels of various proteins, including phospho-Nf-kappa B, BCL-2, BAX, p-53, and cyclin D1 as well as RAGE were measured using Western blot analysis. The hydro-ethanol extract of the aerial part possessed the highest phenolic (56.81 mg GAE/g) and flavonoid (63.92 mg RE/g) contents. In-depth profiling of the specialized metabolites by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) allowed for the identification and annotation of 65 compounds, including phenolic acids and glycosides, flavones, flavonols, chalcones, dihydrochalcones, and saponins. The hydro-ethanol extract of the aerial parts (132.65, 180.87, 172.46, and 108.37 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) and the ethanol extract of the rhizomes (415.06, 638.30, 477.77, and 301.02 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) exhibited the highest free radical scavenging and reducing activities. The ethanol and hydro-ethanol extracts of both the P. auriculata aerial part and rhizomes exhibited higher inhibitory activity against acetylcholinesterase, while the hydro-ethanol extracts (1.16 mmol ACAE/g, for both the aerial part and rhizomes extracts) were more active in the inhibition of alpha-glucosidase. After the treatment of an HT-29 colorectal cancer cell line with the extracts, the apoptosis mechanism was initiated, the integrity of the ECM was remodeled, and cell proliferation was also taken under control. In this way, Primula extracts were shown to be potential drug sources in the treatment of colorectal cancer. They were also detected as natural MMP inhibitors. The findings presented in the present study appraise the bioactivity of P. auriculata, an understudied species. Additional assessment is required to evaluate the cytotoxicity of P. auriculata as well as its activity in ex vivo systems.
Citation - Scopus: 4
Jejunojejunal intussusception secondary to lipoma in an adult: a case report
(Blackwell Munksgaard, 2002) Çakırer, Sinan; Şırvancı, Mustafa; Duran, Cihan
Lipoma is a rare cause of adult intussusception. We present the CT findings of an adult patient with jejunojejunal intussusception secondary to submucosal lipoma as the lead point in this case report.
Citation - WoS: 2
Citation - Scopus: 4
A left pulmonary artery aneurysm secondary to pulmonary hypertension
(2001) Sönmez, Bingür; Tansal, Selim; Ünal, Mehmet; Korkut, Ali Kubilay; Yağan, Naci Erciyes; Demirsoy, Ergun; Arbatlı, Harun; Aytekin, Vedat
We report a case of pulmonary trunk aneurysm extending into the left pulmonary artery due to pulmonary hypertension secondary to mitral valve disease. The mitral valve was replaced with a bileaflet mechanical prosthesis. A Dacron graft interposed between main trunk and left pulmonary artery branch and right pulmonary branch attached to the graft in an end-to-side fashion. Early postoperative angiogram revealed a very successful treatment.
Citation - WoS: 7
Citation - Scopus: 7
Potential allosteric sites captured in glycolytic enzymes via residue-based network models: Phosphofructokinase, glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase
(Elsevier, 2022) Akdoğan, Ebru Demet; Inan, Tugce; Kurkcuoglu, Ozge; Akten, Ebru Demet
Likelihood of new allosteric sites for glycolytic enzymes, phosphofructokinase (PFK), glyceraldehyde-3phosphate dehydrogenase (GADPH) and pyruvate kinase (PK) was evaluated for bacterial, parasitic and human species. Allosteric effect of a ligand binding at a site was revealed on the basis of low-frequency normal modes via C alpha-harmonic residue network model. In bacterial PFK, perturbation of the proposed allosteric site outperformed the known allosteric one, producing a high amount of stabilization or reduced dynamics, on all catalytic regions. Another proposed allosteric spot at the dimer interface in parasitic PFK exhibited major stabilization effect on catalytic regions. In parasitic GADPH, the most desired allosteric response was observed upon perturbation of its tunnel region which incorporated key residues for functional regulation. Proposed allosteric site in bacterial PK produced a satisfactory allosteric response on all catalytic regions, whereas in human and parasitic PKs, a partial inhibition was observed. Residue network model based solely on contact topology identified the 'hub residues' with high betweenness tracing plausible allosteric communication pathways between distant functional sites. For both bacterial PFK and PK, proposed sites accommodated hub residues twice as much as the known allosteric site. Tunnel region in parasitic GADPH with the strongest allosteric effect among species, incorporated the highest number of hub residues. These results clearly suggest a one-to-one correspondence between the degree of allosteric effect and the number of hub residues in that perturbation site, which increases the likelihood of its allosteric nature.
Citation - WoS: 13
Citation - Scopus: 21
A Quality-of-Service-Aware Service Composition Method in the Internet of Things Using a Multi-Objective Fuzzy-Based Hybrid Algorithm
(Mdpi, 2023) Jafari Navimipour, Nima; Khandagh, Saeed; Navimipour, Nima Jafari
The Internet of Things (IoT) represents a cutting-edge technical domain, encompassing billions of intelligent objects capable of bridging the physical and virtual worlds across various locations. IoT services are responsible for delivering essential functionalities. In this dynamic and interconnected IoT landscape, providing high-quality services is paramount to enhancing user experiences and optimizing system efficiency. Service composition techniques come into play to address user requests in IoT applications, allowing various IoT services to collaborate seamlessly. Considering the resource limitations of IoT devices, they often leverage cloud infrastructures to overcome technological constraints, benefiting from unlimited resources and capabilities. Moreover, the emergence of fog computing has gained prominence, facilitating IoT application processing in edge networks closer to IoT sensors and effectively reducing delays inherent in cloud data centers. In this context, our study proposes a cloud-/fog-based service composition for IoT, introducing a novel fuzzy-based hybrid algorithm. This algorithm ingeniously combines Ant Colony Optimization (ACO) and Artificial Bee Colony (ABC) optimization algorithms, taking into account energy consumption and Quality of Service (QoS) factors during the service selection process. By leveraging this fuzzy-based hybrid algorithm, our approach aims to revolutionize service composition in IoT environments by empowering intelligent decision-making capabilities and ensuring optimal user satisfaction. Our experimental results demonstrate the effectiveness of the proposed strategy in successfully fulfilling service composition requests by identifying suitable services. When compared to recently introduced methods, our hybrid approach yields significant benefits. On average, it reduces energy consumption by 17.11%, enhances availability and reliability by 8.27% and 4.52%, respectively, and improves the average cost by 21.56%.
Citation - WoS: 7
Citation - Scopus: 8
A Radiofrequency modified maze and valve procedure through a port-access approach
(Forum Multimedia Publishing LLC., 2003) Güden, Mustafa; Akpınar, Belhhan; Sağbaş, Ertan; Sanisoğlu, İlhan; Ergenoğlu, Mehmet U.; Özbek, Uğur
Background: The aim of the study was to assess the feasibility and effectiveness of the irrigated radiofrequency modified maze procedure through a port-access approach during mitral valve surgery. Methods: Forty-three patients with atrial fibrillation (AF) and mitral valve disease underwent a combined procedure through a port-access approach. The indication was a history of continuous AF for more than 6 months in patients eligible for minimally invasive mitral valve surgery. Results: The incidence of early mortality was 1 patient (2.3%) and that of freedom from AF was 100% at the end of the operation (70% of patients with normal sinus rhythm 30% with a pacemaker). One patient (2.3%) required permanent pacemaker implantation after surgery. One patient (2.3%) required reoperation for bleeding. There were no reoperations for failed valve repairs. The incidences of freedom from AF were 87% and 92% at 6 and 12 months respectively. At 12 months functional capacity had improved significantly (P < .05). There were no procedure-related complications. No thromboembolic events were detected during follow-up. Conclusion: The port-access approach provided a good access for both valve surgery and the radiofrequency maze procedure. The combination of direct and videoscopic vision allowed an adequate view and led to a safe and efficient combined procedure. Short- and intermediate-term follow-up results were favorable.
Citation - WoS: 3
Relationship between dyslipidemia C-Reactive Protein and serological evidence of chlamydia pneumoniae in Turkish patients with coronary artery diseases
(Luigi Ponzio E Figlio, 2004) Türkoğlu, Celalettin; Sönmez, Emine; Aydınlı, Aydın
Relationship between dyslipidemia C-Reactive Protein (CRP) and serological evidence of Chlamydia pneumoniae was investigated in a Turkish population with coronary artery disease. This prospective randomized blinded study was carried out in Florence Nightingale Hospital which is affiliated to Kadir Has University Medical Faculty. Thirty-two patients with acute coronary artery diseases (ACAD) 32 patients with chronic coronary artery diseases (CCAD) and 26 healthy controls (HC) were included in the study We detected serum concentrations of C. pneumoniae IgG IgA and IgM by ELISA method. We measured total cholesterol trigliseride LDL and HDL- cholesterol levels to determine dyslipidemia which was defined as total cholesterol >200 mg/dL trigliserid > 150 Mg/dL LDL >130 mg/dL HDL <45 mg/dL. CRP levels were also measured. Seropositivity to C. pneumoniae IgG was 84.3% 100% and 65.3%

Browse

Browsing PubMed İndeksli Yayınlar Koleksiyonu by WoS Q "N/A"