Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials
Loading...
Date
2002
Authors
Hanagasi, Hasmet A.
Gurvit, I. Hakan
Ermutlu, Numan
Kaptanoğlu, Gulustu
Karamürsel, Sacit
Idrisoğlu, Halil A.
Emre, Murat
Demiralp, Tamer
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Science Bv
Open Access Color
OpenAIRE Downloads
OpenAIRE Views
Abstract
The presence of subclinical cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) is investigated using neuropsychological assessment and event-related potential recordings (ERP). An extensive battery of neuropsychological tests assessing the domains of attention memory language visuo-spatial and executive functions were administered to 20 non-demented patients with sporadic ALS and 13 age- and education-matched healthy control subjects. Mismatch negativity (MMN) P3b P3a (novelty P300) and contingent negative variation (CNV) were recorded. ALS patients were significantly impaired in tests of working memory sustained attention response inhibition naming verbal fluency and complex visuo-spatial processing. The memory impairment seemed to be secondary to deficits in forming learning strategies and retrieval. In ERP recordings P3a and P3b amplitudes of ALS patients were lower compared with the controls P3a latencies were significantly longer and mean CNV amplitudes were higher. These results indicate subclinical impairment of cognitive functions in patients with ALS. The pattern of cognitive impairment suggests the dysfunction of the frontal network. (C) 2002 Elsevier Science B.V. All rights reserved.
Description
Keywords
Amyotrophic lateral sclerosis, Neuropsychology, Event-related potential, Frontal dysfunction
Turkish CoHE Thesis Center URL
Fields of Science
Citation
105
WoS Q
N/A
Scopus Q
N/A
Source
Volume
14
Issue
2
Start Page
234
End Page
244