Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation

dc.contributor.author Yılmaz, Mert
dc.contributor.author Ener, Serdar
dc.contributor.author Akalın, Halis
dc.contributor.author Sağdıç, Kadir
dc.contributor.author Serdar, O. Akin
dc.contributor.author Cengiz, Mete
dc.date.accessioned 2019-06-27T08:01:07Z
dc.date.available 2019-06-27T08:01:07Z
dc.date.issued 1999
dc.description.abstract The systemic inflammatory response to cardiopulmonary bypass (CPB) is associated with increased production of cytokines. This systemic inflammatory response characterized by the activation of interleukin-6 (IL-6) and interleukin-8 (IL-8) during and after CPB is well documented. A prospective randomized double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (MPSS) on the circulating levels of serum cytokines and clinical outcome. Twenty patients were randomly divided into two groups on the basis of the administration of low-dose(1 mg/kg) MPSS in = 10) and placebo in = 10) into the pump prime solution. All patients were scheduled to undergo a primary en_US]
dc.description.abstract elective coronary artery bypass grafting operation. Patients receiving concurrent corticosteroids salicylates dipyridamol or anticoagulants were excluded from the study. Other exclusion criteria were concurrent chronic obstructive pulmonary disease chronic renal failure insulin-dependent diabetes congestive cardiac failure peptic ulcer history prior cardiac operations recent tin a one-month period) myocardial infarction and steroid dependency. Mild systemic hypothermia (30-32 degrees C rectal) was assured during the CPB. Four blood samples were drawn from the radial artery catheter immediately before starting CPB (T1) following protamine administration (T2) and at 24 (T3) and 48 h (T4) after completion of CPB. In each sample creatine kinase-myocardial band (CK-MB) white blood cell (WBC) IL-6 and IL-8 levels were measured. IL-6 and IL-8 concentrations were measured by enzyme immunoassay and enzyme-linked immunoabsorbant assay methods. en_US]
dc.identifier.citationcount 30
dc.identifier.doi 10.1177/026765919901400308 en_US
dc.identifier.endpage 206
dc.identifier.issn 0267-6591 en_US
dc.identifier.issn 0267-6591
dc.identifier.issue 3
dc.identifier.pmid 10411250 en_US
dc.identifier.scopus 2-s2.0-0032982381 en_US
dc.identifier.scopusquality N/A
dc.identifier.startpage 201 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/264
dc.identifier.uri https://doi.org/10.1177/026765919901400308
dc.identifier.volume 14 en_US
dc.identifier.wos WOS:000082332100008 en_US
dc.identifier.wosquality N/A
dc.institutionauthor Yılmaz, Mert en_US
dc.language.iso en en_US
dc.publisher Arnold Hodder Headline Plc. en_US
dc.relation.journal Perfusion en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 37
dc.title Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation en_US
dc.type Article en_US
dc.wos.citedbyCount 32
dspace.entity.type Publication

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