Which anesthetic agent alters the hemodynamic status during pediatric catheterization? Comparison of propofol versus ketamine

dc.contributor.authorOklu, E
dc.contributor.authorBulutcu, Füsun S.
dc.contributor.authorYalçın, Yalim
dc.contributor.authorÖzbek, Uğur
dc.contributor.authorCakali, Emine
dc.contributor.authorBayındır, Osman
dc.date.accessioned2019-06-27T08:00:56Z
dc.date.available2019-06-27T08:00:56Z
dc.date.issued2003
dc.description.abstractObjective: To compare the effects of propofol and ketamine on systemic and pulmonary circulations in pediatric patients scheduled for elective cardiac catheterization. Design: Prospective randomized and blinded. Setting: University hospital. Participants: Children (n = 41) undergoing cardiac catheterization. Interventions: All children were premedicated with oral midazolam 60 minutes before the procedure. Patients were separated into 3 groups according to shunts diagnosed by transthoracic echocardiography before the catheterization procedure: patients without cardiac shunt (Group 1 n = 11) left-to-right shunt (Group 11 n = 12) and right-to-left shunt (Group III n = 18). A continuous infusion of propofol (100200 mug/kg/min) or ketamine (50-75 mug/kg/min) was randomly started in all groups to obtain immobility during the procedure. Hemodynamic data including systemic venous pulmonary artery and vein aortic saturations and pressures were recordeden_US]
dc.description.abstractQp/Qs were calculated. The same set of data was recorded before discontinuation of infusions at the end of the procedure. Measurements and Main Results: After the propofol administration in all 3 patient groups propofol infusion was associated with significant decreases in systemic mean arterial pressure. In groups with cardiac shunts (Group 11 and 111) propofol infusion significantly decreased systemic vascular resistance and increased systemic blood flow whereas pulmonary vascular resistance and pulmonary blood flow did not change significantly. These changes resulted in decreased left-to-right shunting and increased right-to-left shuntingen_US]
dc.description.abstractthe pulmonary-to-systemic flow ratio decreased significantly. On the other hand after ketamine infusion systemic mean arterial pressure increased significantly in all patient groups but pulmonary mean arterial pressure systemic vascular resistance and pulmonary vascular resistance were unchanged. Conclusion: In children with cardiac shunting the principal hemodynamic effect of propofol is a decrease in systemic vascular resistance. In children with intracardiac shunting this results in an increase in right-to-left shunting and a decrease in the ratio of pulmonary to systemic blood flow which may lead to arterial desaturation. Ketamine did not produce these changes. The authors suggested that during cardiac catheterization in children both the anesthesiologists and cardiologists need to know that anesthetic agents can significantly alter the hemodynamic status in children with complex congenital heart defects and affect the results of hemodynamic calculations that are important for decision-making and treatment of these patients. (C) 2003 Elsevier Inc. All rights reserved.en_US]
dc.identifier.citation76
dc.identifier.doi10.1053/j.jvca.2003.09.009en_US
dc.identifier.endpage690
dc.identifier.issn1053-0770en_US
dc.identifier.issn1053-0770
dc.identifier.issue6
dc.identifier.pmid14689405en_US
dc.identifier.scopus2-s2.0-0347716456en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage686en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/169
dc.identifier.urihttps://doi.org/10.1053/j.jvca.2003.09.009
dc.identifier.volume17en_US
dc.identifier.wosWOS:000187712900002en_US
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherW.B. Saunders Co Ltden_US
dc.relation.journalJournal of Cardiothoracic and Vascular Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPediatricen_US
dc.subjectCardiac catheterizationen_US
dc.subjectPropofolen_US
dc.subjectKetamineen_US
dc.titleWhich anesthetic agent alters the hemodynamic status during pediatric catheterization? Comparison of propofol versus ketamineen_US
dc.typeArticleen_US
dspace.entity.typePublication

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