Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

dc.authoridUba, Abdullahi Ibrahim/0000-0002-0853-108X
dc.authoridMustafa, Ahmed/0000-0002-1533-1553
dc.authoridAbouelenein, Doaa/0000-0001-6053-3712
dc.authoridCaprioli, Giovanni/0000-0002-5530-877X
dc.authorwosidUba, Abdullahi Ibrahim/P-3971-2019
dc.contributor.authorOmer, Haifa A. A.
dc.contributor.authorCaprioli, Giovanni
dc.contributor.authorAbouelenein, Doaa
dc.contributor.authorMustafa, Ahmed M.
dc.contributor.authorUba, Abdullahi Ibrahim
dc.contributor.authorAk, Gunes
dc.contributor.authorOzturk, Refiye Beyza
dc.date.accessioned2023-10-19T15:12:05Z
dc.date.available2023-10-19T15:12:05Z
dc.date.issued2022
dc.department-temp[Omer, Haifa A. A.] Sudan Univ Sci & Technol SUST, Dept Bot, Fac Sci, POB 407, Khartoum, Sudan; [Omer, Haifa A. A.; Yagi, Sakina] Univ Khartoum, Dept Bot, Fac Sci, POB 321, Khartoum, Sudan; [Caprioli, Giovanni; Abouelenein, Doaa; Mustafa, Ahmed M.] Univ Camerino, Sch Pharm, Chem Interdisciplinary Project CHIP, Via Madonna delle Carceri, I-62032 Camerino, Italy; [Uba, Abdullahi Ibrahim] Kadir Has Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, TR-34083 Istanbul, Turkey; [Ak, Gunes; Ozturk, Refiye Beyza; Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, Physiol & Biochem Res Lab, TR-42130 Konya, Turkeyen_US
dc.description.abstractSeveral species within the genera Cassia or Senna have a treasure of traditional medicines worldwide and can be a promising source of bioactive molecules. The objective of the present study was to evaluate the phenolic content and antioxidant and enzyme inhibition activities of leaf methanolic extracts of C. fistula L., C. grandis L., S. alexandrina Mill., and S. italica Mill. The two Cassia spp. contained higher total polyphenolic content (42.23-49.75 mg GAE/g) than the two Senna spp., and C. fistula had significantly (p < 0.05) the highest concentration. On the other hand, the Senna spp. showed higher total flavonoid content (41.47-59.24 mg rutin equivalent per g of extract) than that found in the two Cassia spp., and S. alexandrina significantly (p < 0.05) accumulated the highest amount. HPLC-MS/MS analysis of 38 selected bioactive compounds showed that the majority of compounds were identified in the four species, but with sharp variations in their concentrations. C. fistula was dominated by epicatechin (8928.75 mu g/g), C. grandis by kaempferol-3-glucoside (47,360.04 mu g/g), while rutin was the major compound in S. italica (17,285.02 mu g/g) and S. alexandrina (6381.85). The methanolic extracts of the two Cassia species exerted significantly (p < 0.05) higher antiradical activity, metal reducing capacity, and total antioxidant activity than that recorded from the two Senna species' methanolic extracts, and C. fistula displayed significantly (p < 0.05) the highest values. C. grandis significantly (p < 0.05) exhibited the highest metal chelating power. The results of the enzyme inhibition activity showed that the four species possessed anti-AChE activity, and the highest value, but not significantly (p >= 0.05) different from those obtained by the two Cassia spp., was exerted by S. alexandrina. The Cassia spp. exhibited significantly (p < 0.05) higher anti-BChE and anti-Tyr properties than the Senna spp., and C. grandise revealed significantly (p < 0.05) the highest values. C. grandise revealed significantly (p < 0.05) the highest alpha- amylase inhibition, while the four species had more or less the same effect against the alpha-glucosidase enzyme. Multivariate analysis and in silico studies showed that many of the identified phenols may play key roles as antioxidant and enzyme inhibitory properties. Thus, these Cassia and Senna species could be a promising source of natural bioactive agents with beneficial effects for human health.en_US
dc.identifier.citation18
dc.identifier.doi10.3390/molecules27175590en_US
dc.identifier.issn1420-3049
dc.identifier.issue17en_US
dc.identifier.pmid36080355en_US
dc.identifier.scopus2-s2.0-85137608089en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules27175590
dc.identifier.urihttps://hdl.handle.net/20.500.12469/5337
dc.identifier.volume27en_US
dc.identifier.wosWOS:000851985500001en_US
dc.identifier.wosqualityN/A
dc.khas20231019-WoSen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTyrosinase InhibitionEn_Us
dc.subjectExtractsEn_Us
dc.subjectPhytochemicalsEn_Us
dc.subjectConstituentsEn_Us
dc.subjectDerivativesEn_Us
dc.subjectFlavonoidsEn_Us
dc.subjectPartsEn_Us
dc.subjectPlantEn_Us
dc.subjectAcidEn_Us
dc.subjectL.En_Us
dc.subjectTyrosinase Inhibition
dc.subjectExtracts
dc.subjectPhytochemicals
dc.subjectConstituents
dc.subjectDerivatives
dc.subjectFlavonoids
dc.subjectCassia sppen_US
dc.subjectParts
dc.subjectSenna sppen_US
dc.subjectPlant
dc.subjectphenolic compoundsen_US
dc.subjectAcid
dc.subjectantioxidanten_US
dc.subjectL.
dc.subjectenzyme inhibitionen_US
dc.titlePhenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Speciesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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