Apolipoprotein E polymorphism in Turkish subjects with Type 2 diabetes mellitus: Allele frequency and relation to serum lipid concentrations

dc.contributor.authorDuman, Belgin Süsleyici
dc.contributor.authorÖztürk, Melek
dc.contributor.authorYilmazer, Selma
dc.contributor.authorHatemi, Hüsrev
dc.date.accessioned2019-06-27T08:00:54Z
dc.date.available2019-06-27T08:00:54Z
dc.date.issued2004
dc.description.abstractThe role of apolipoprotein E (apoE) genotypes in modulating plasma lipid and apolipoprotein levels was studied in 112 patients with Type 2 diabetes mellitus (T2DM) and 94 healthy individuals. ApoE genotypes were identified by PCR amplification and subsequent restriction endonuclease digestion. The apoE allele and genotype frequencies were similar in both the diabetic and control subjects. The apoE allele frequencies were found to be 74.3 for e3 10.1 for e2 15.6 for e4 in the diabetic group and 68.1 for e3 13.2 for e2 and 18.7 for e4 in the control group. Sex-specific genotypic distribution of apoE polymorphism did not differ between the study groups. To elucidate the association of apoE with lipid abnormalities with respect to gender serum lipid and apolipoprotein levels were compared among apo e2 (e2/2 and e3/2) e3 (e3/3) and e4 (e4/3 and e4/4) groups of T2DM and control subjects. Apo e2 allele was found to be associated to triglycerides for both sexes and associated to glucose and BMI only in females. Subjects with e2 allele had higher levels of BMI glucose and triglyceride in comparison to e3 and e4. Our data suggest that genetic variation at the apoE locus in Turkish subjects is a genetic factor that influences lipid levels. Further studies attempting to correlate apoE polymorphism with lipid profile in a large number of individuals would be helpful in establishing the true significance of this polymorphism in the Turkish population. (C) 2004 Editrice Kurtis.en_US]
dc.identifier.citation20
dc.identifier.endpage274
dc.identifier.issn0394-3402en_US
dc.identifier.issn0394-3402
dc.identifier.issue5
dc.identifier.pmid16295048en_US
dc.identifier.scopus2-s2.0-12344300720en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage267en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/145
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/16295048
dc.identifier.volume17en_US
dc.identifier.wosWOS:000226275900003en_US
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherEDITRICE KURTIS S R Len_US
dc.relation.journalDiabetes Nutrition & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2 diabetes mellitusen_US
dc.subjectApolipoprotein Een_US
dc.subjectGenotypingen_US
dc.subjectSerum lipidsen_US
dc.subjectLipoproteinsen_US
dc.subjectGenderen_US
dc.titleApolipoprotein E polymorphism in Turkish subjects with Type 2 diabetes mellitus: Allele frequency and relation to serum lipid concentrationsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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