Polymorphisms at the Ligand Binding Site of the Vitamin D Receptor Gene and Osteomalacia

dc.contributor.author Ak, Duygu Gezen
dc.contributor.author Kahraman, Hakkı
dc.contributor.author Dursun, Erdinç
dc.contributor.author Duman, Belgin Süsleyici
dc.contributor.author Erensoy, Nevin
dc.contributor.author Alagöl, Faruk
dc.contributor.author Tanakol, Refik
dc.contributor.author Yilmazer, Selma
dc.date.accessioned 2019-06-27T08:00:53Z
dc.date.available 2019-06-27T08:00:53Z
dc.date.issued 2005
dc.description.abstract Vitamin D receptor (VDR) gene polymorphisms have been suggested as possible determinants of bone mineral density (BMD) and calcium metabolism. In this study our aim was to determine whether there is an association between VDR gene polymorphism and osteomalacia or not. We determined ApaI and TaqI polymorphisms in the vitamin D receptor gene in 24 patients with osteomalacia and 25 age-matched healthy controls. Serum calcium phosphorus ALP PTH 25OHD levels were also examined. We used PCR and RFLP methods to test for an association between osteomalacia and polymorphisms within intron 8 and exon 9 of the VDR gene. When the control and patients were compared for their ApaI and TaqI genotypes there was no relationship between VDR gene allelic polymorphisms and osteomalacia. Whereas a nearly significant difference for A allele was found in the allellic distribution of the patients (p=0.08). Also no association between biochemical data and VDR gene polymorphisms was observed. en_US]
dc.identifier.citationcount 9
dc.identifier.doi 10.1155/2005/645260 en_US
dc.identifier.endpage 197
dc.identifier.issn 0278-0240 en_US
dc.identifier.issn 1875-8630 en_US
dc.identifier.issn 0278-0240
dc.identifier.issn 1875-8630
dc.identifier.issue 4
dc.identifier.pmid 16403954 en_US
dc.identifier.scopus 2-s2.0-30444443813 en_US
dc.identifier.startpage 191 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/138
dc.identifier.uri https://doi.org/10.1155/2005/645260
dc.identifier.volume 21 en_US
dc.identifier.wos WOS:000235915800004 en_US
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Hindawi Ltd en_US
dc.relation.journal Disease Markers en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 11
dc.subject Vitamin D en_US
dc.subject Osteomalacia en_US
dc.subject Vitamin D receptor gene en_US
dc.subject ApaI en_US
dc.subject TaqI en_US
dc.title Polymorphisms at the Ligand Binding Site of the Vitamin D Receptor Gene and Osteomalacia en_US
dc.type Article en_US
dc.wos.citedbyCount 10
dspace.entity.type Publication

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