Aryl Butenoic Acid Derivatives as a New Class of Histone Deacetylase Inhibitors: Synthesis in Vitro Evaluation and Molecular Docking Studies

dc.contributor.author Esiyok, Peruze Ayhan
dc.contributor.author Yelekçi, Kemal
dc.contributor.author Seven, özlem
dc.contributor.author Eymur, Guluzar
dc.contributor.author Tatar, Gamze Bora
dc.contributor.author Erden, Didem Dayangaç
dc.contributor.author Yelekçi, Kemal
dc.contributor.author Yurter, Hayat
dc.contributor.author Demir, Ayhan S.
dc.contributor.other Molecular Biology and Genetics
dc.date.accessioned 2019-06-27T08:03:13Z
dc.date.available 2019-06-27T08:03:13Z
dc.date.issued 2014
dc.department Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Biyoinformatik ve Genetik Bölümü en_US
dc.description.abstract New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group with a double bond in the short linker as well as metal binding groups enoic ester and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies. en_US]
dc.identifier.citationcount 2
dc.identifier.doi 10.3906/kim-1305-56 en_US
dc.identifier.endpage 344
dc.identifier.issn 1300-0527 en_US
dc.identifier.issn 1300-0527
dc.identifier.issue 2
dc.identifier.scopus 2-s2.0-84897899399 en_US
dc.identifier.startpage 338 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/757
dc.identifier.uri https://doi.org/10.3906/kim-1305-56
dc.identifier.volume 38 en_US
dc.identifier.wos WOS:000332942200016 en_US
dc.identifier.wosquality Q4
dc.institutionauthor Yelekçi, Kemal en_US
dc.language.iso en en_US
dc.publisher Scientific Technical Research Council Turkey-Tubitak en_US
dc.relation.journal Turkish Journal of Chemistry en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 3
dc.subject Histone deacetylase inhibition activity en_US
dc.subject Aryl butenoic acid derivatives en_US
dc.subject Molecular docking en_US
dc.title Aryl Butenoic Acid Derivatives as a New Class of Histone Deacetylase Inhibitors: Synthesis in Vitro Evaluation and Molecular Docking Studies en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication
relation.isAuthorOfPublication 9407938e-3d31-453b-9199-aaa8280a66c5
relation.isAuthorOfPublication.latestForDiscovery 9407938e-3d31-453b-9199-aaa8280a66c5
relation.isOrgUnitOfPublication 71ce8622-7449-4a6a-8fad-44d881416546
relation.isOrgUnitOfPublication.latestForDiscovery 71ce8622-7449-4a6a-8fad-44d881416546

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