Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner
dc.authorid | Argunşah, Ali Özgür/0000-0002-3082-3775 | |
dc.authorscopusid | 24723512300 | |
dc.authorscopusid | 24511960600 | |
dc.authorwosid | Argunşah, Ali Özgür/AAF-7464-2019 | |
dc.contributor.author | Argunşah, Ali Özgür | |
dc.contributor.author | Israely, Inbal | |
dc.date.accessioned | 2024-06-23T21:38:28Z | |
dc.date.available | 2024-06-23T21:38:28Z | |
dc.date.issued | 2023 | |
dc.department | Kadir Has University | en_US |
dc.department-temp | [Argunsah, Ali Ozgur] Univ Zurich, Brain Res Inst HiFo, Lab Neuronal Circuit Assembly, Zurich, Switzerland; [Argunsah, Ali Ozgur] Kadir Has Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, Istanbul, Turkiye; [Israely, Inbal] Univ Washington, Dept Physiol & Biophys, Sch Med, Seattle, WA 98195 USA | en_US |
dc.description | Argunşah, Ali Özgür/0000-0002-3082-3775 | en_US |
dc.description.abstract | Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns. Unstimulated clusters of neighboring spines in and around the site of stimulation can also undergo alterations in strength. Usually, when plasticity is induced at single dendritic spines with glutamate uncaging, neighboring spines do not show any significant structural fluctuations. Here, using two-photon imaging and glutamate uncaging at single dendritic spines of hippocampal pyramidal neurons, we show that structural modifications at unstimulated neighboring spines occur and are a function of the temporal pattern of the plasticity-inducing stimulus. Further, the relative location of the unstimulated neighbors within the local dendritic segment correlates with the extent of heterosynaptic plasticity that is observed. These findings indicate that naturalistic patterns of activity at single spines can shape plasticity at nearby clusters of synapses, and may play a role in priming local inputs for further modifications. | en_US |
dc.description.sponsorship | Bial Foundation [161/10-2010]; FCT [PTDC/SAU-NMC/122035/2010]; National Institutes of Health/NINDS [1R01NS112485]; Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/51264/2010] | en_US |
dc.description.sponsorship | AA was supported by Fundacao para a Ciencia e a Tecnologia (FCT) grant SFRH/BD/51264/2010. The study was also supported by grants from the Bial Foundation (161/10-2010), FCT (PTDC/SAU-NMC/122035/2010), and the National Institutes of Health/NINDS (1R01NS112485) to II. | en_US |
dc.identifier.citation | 1 | |
dc.identifier.doi | 10.3389/fncel.2023.1253446 | |
dc.identifier.issn | 1662-5102 | |
dc.identifier.pmid | 37829671 | |
dc.identifier.scopus | 2-s2.0-85173641227 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.uri | https://doi.org/10.3389/fncel.2023.1253446 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12469/5801 | |
dc.identifier.volume | 17 | en_US |
dc.identifier.wos | WOS:001080858600001 | |
dc.identifier.wosquality | N/A | |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media Sa | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | dendritic spine | en_US |
dc.subject | structural plasticity | en_US |
dc.subject | synaptic plasticity | en_US |
dc.subject | heterosynaptic plasticity | en_US |
dc.subject | metaplasticity | en_US |
dc.subject | naturalistic activity | en_US |
dc.subject | neighboring spines LTP | en_US |
dc.title | Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 527c255a-82df-472d-bf31-fcf997da9806 | |
relation.isAuthorOfPublication.latestForDiscovery | 527c255a-82df-472d-bf31-fcf997da9806 |