Homosynaptic Plasticity Induction Causes Heterosynaptic Changes at the Unstimulated Neighbors in an Induction Pattern and Location-Specific Manner

dc.authorid Argunşah, Ali Özgür/0000-0002-3082-3775
dc.authorscopusid 24723512300
dc.authorscopusid 24511960600
dc.authorwosid Argunşah, Ali Özgür/AAF-7464-2019
dc.contributor.author Argunsah, Ali Ozgur
dc.contributor.author Argunşah, Ali Özgür
dc.contributor.author Israely, Inbal
dc.contributor.other Molecular Biology and Genetics
dc.date.accessioned 2024-06-23T21:38:28Z
dc.date.available 2024-06-23T21:38:28Z
dc.date.issued 2023
dc.department Kadir Has University en_US
dc.department-temp [Argunsah, Ali Ozgur] Univ Zurich, Brain Res Inst HiFo, Lab Neuronal Circuit Assembly, Zurich, Switzerland; [Argunsah, Ali Ozgur] Kadir Has Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, Istanbul, Turkiye; [Israely, Inbal] Univ Washington, Dept Physiol & Biophys, Sch Med, Seattle, WA 98195 USA en_US
dc.description Argunşah, Ali Özgür/0000-0002-3082-3775 en_US
dc.description.abstract Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns. Unstimulated clusters of neighboring spines in and around the site of stimulation can also undergo alterations in strength. Usually, when plasticity is induced at single dendritic spines with glutamate uncaging, neighboring spines do not show any significant structural fluctuations. Here, using two-photon imaging and glutamate uncaging at single dendritic spines of hippocampal pyramidal neurons, we show that structural modifications at unstimulated neighboring spines occur and are a function of the temporal pattern of the plasticity-inducing stimulus. Further, the relative location of the unstimulated neighbors within the local dendritic segment correlates with the extent of heterosynaptic plasticity that is observed. These findings indicate that naturalistic patterns of activity at single spines can shape plasticity at nearby clusters of synapses, and may play a role in priming local inputs for further modifications. en_US
dc.description.sponsorship Bial Foundation [161/10-2010]; FCT [PTDC/SAU-NMC/122035/2010]; National Institutes of Health/NINDS [1R01NS112485]; Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/51264/2010] en_US
dc.description.sponsorship AA was supported by Fundacao para a Ciencia e a Tecnologia (FCT) grant SFRH/BD/51264/2010. The study was also supported by grants from the Bial Foundation (161/10-2010), FCT (PTDC/SAU-NMC/122035/2010), and the National Institutes of Health/NINDS (1R01NS112485) to II. en_US
dc.identifier.citationcount 1
dc.identifier.doi 10.3389/fncel.2023.1253446
dc.identifier.issn 1662-5102
dc.identifier.pmid 37829671
dc.identifier.scopus 2-s2.0-85173641227
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3389/fncel.2023.1253446
dc.identifier.uri https://hdl.handle.net/20.500.12469/5801
dc.identifier.volume 17 en_US
dc.identifier.wos WOS:001080858600001
dc.language.iso en en_US
dc.publisher Frontiers Media Sa en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 2
dc.subject dendritic spine en_US
dc.subject structural plasticity en_US
dc.subject synaptic plasticity en_US
dc.subject heterosynaptic plasticity en_US
dc.subject metaplasticity en_US
dc.subject naturalistic activity en_US
dc.subject neighboring spines LTP en_US
dc.title Homosynaptic Plasticity Induction Causes Heterosynaptic Changes at the Unstimulated Neighbors in an Induction Pattern and Location-Specific Manner en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication
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