Homosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manner

dc.authoridArgunşah, Ali Özgür/0000-0002-3082-3775
dc.authorscopusid24723512300
dc.authorscopusid24511960600
dc.authorwosidArgunşah, Ali Özgür/AAF-7464-2019
dc.contributor.authorArgunşah, Ali Özgür
dc.contributor.authorIsraely, Inbal
dc.date.accessioned2024-06-23T21:38:28Z
dc.date.available2024-06-23T21:38:28Z
dc.date.issued2023
dc.departmentKadir Has Universityen_US
dc.department-temp[Argunsah, Ali Ozgur] Univ Zurich, Brain Res Inst HiFo, Lab Neuronal Circuit Assembly, Zurich, Switzerland; [Argunsah, Ali Ozgur] Kadir Has Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, Istanbul, Turkiye; [Israely, Inbal] Univ Washington, Dept Physiol & Biophys, Sch Med, Seattle, WA 98195 USAen_US
dc.descriptionArgunşah, Ali Özgür/0000-0002-3082-3775en_US
dc.description.abstractDendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns. Unstimulated clusters of neighboring spines in and around the site of stimulation can also undergo alterations in strength. Usually, when plasticity is induced at single dendritic spines with glutamate uncaging, neighboring spines do not show any significant structural fluctuations. Here, using two-photon imaging and glutamate uncaging at single dendritic spines of hippocampal pyramidal neurons, we show that structural modifications at unstimulated neighboring spines occur and are a function of the temporal pattern of the plasticity-inducing stimulus. Further, the relative location of the unstimulated neighbors within the local dendritic segment correlates with the extent of heterosynaptic plasticity that is observed. These findings indicate that naturalistic patterns of activity at single spines can shape plasticity at nearby clusters of synapses, and may play a role in priming local inputs for further modifications.en_US
dc.description.sponsorshipBial Foundation [161/10-2010]; FCT [PTDC/SAU-NMC/122035/2010]; National Institutes of Health/NINDS [1R01NS112485]; Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/51264/2010]en_US
dc.description.sponsorshipAA was supported by Fundacao para a Ciencia e a Tecnologia (FCT) grant SFRH/BD/51264/2010. The study was also supported by grants from the Bial Foundation (161/10-2010), FCT (PTDC/SAU-NMC/122035/2010), and the National Institutes of Health/NINDS (1R01NS112485) to II.en_US
dc.identifier.citation1
dc.identifier.doi10.3389/fncel.2023.1253446
dc.identifier.issn1662-5102
dc.identifier.pmid37829671
dc.identifier.scopus2-s2.0-85173641227
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3389/fncel.2023.1253446
dc.identifier.urihttps://hdl.handle.net/20.500.12469/5801
dc.identifier.volume17en_US
dc.identifier.wosWOS:001080858600001
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdendritic spineen_US
dc.subjectstructural plasticityen_US
dc.subjectsynaptic plasticityen_US
dc.subjectheterosynaptic plasticityen_US
dc.subjectmetaplasticityen_US
dc.subjectnaturalistic activityen_US
dc.subjectneighboring spines LTPen_US
dc.titleHomosynaptic plasticity induction causes heterosynaptic changes at the unstimulated neighbors in an induction pattern and location-specific manneren_US
dc.typeArticleen_US
dspace.entity.typePublication
relation.isAuthorOfPublication527c255a-82df-472d-bf31-fcf997da9806
relation.isAuthorOfPublication.latestForDiscovery527c255a-82df-472d-bf31-fcf997da9806

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