DNA polymorphism of Pvu II site in the lipoprotein lipase gene in patients with non-insulin dependent diabetes mellitus

dc.contributor.authorDuman, Belgin Süsleyici
dc.contributor.authorÖztürk, Melek
dc.contributor.authorYilmazer, Selma
dc.contributor.authorÇağatay, Penbe
dc.contributor.authorHatemi, Hüsrev
dc.date.accessioned2019-06-27T08:00:51Z
dc.date.available2019-06-27T08:00:51Z
dc.date.issued2005
dc.description.abstractWe studied the effect of variation at the lipoprotein lipase (LPL) gene locus on the susceptibility of individuals with non-insulin dependent diabetes mellitus (NIDDM) in a population of 110 NIDDM patients and 91 controls. Our objective was to study the relationship between the LPL-Pvu II polymorphism and NIDDM and lipid metabolism. PCR-RFLP was used to determine the DNA polymorphism of the sixth intron of the LPL gene. The frequencies of the genotypes in case and control groups were 29.1 and 30.8% for P+/P+en_US]
dc.description.abstract45.5 and 36.3% for P+/P-en_US]
dc.description.abstract25.5 and 33% for P-/P- respectively. There was no significant difference in frequencies of genotypes between the two groups. Logistic regression analysis revealed that triacylglycerol (TAG) and apolipoprotein E levels were associated with NIDDM whereas Pvu II genotypes were not found as independent risk factors for the disease. Overall this study demonstrates the role of the Pvu II polymorphism in the LPL gene in modulating plasma lipid/lipoprotein levels in patients with NIDDM. Copyright (c) 2004 John Wiley & Sons Ltd.en_US]
dc.identifier.citation2
dc.identifier.doi10.1027/cbf.1162en_US
dc.identifier.endpage404
dc.identifier.issn0263-6484en_US
dc.identifier.issn1099-0844en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6
dc.identifier.pmid15543643en_US
dc.identifier.scopus2-s2.0-27844474643en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage399en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/116
dc.identifier.urihttps://doi.org/10.1027/cbf.1162
dc.identifier.volume23en_US
dc.identifier.wosWOS:000233352300004en_US
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNIDDMen_US
dc.subjectLipoprotein lipaseen_US
dc.subjectPolymorphismen_US
dc.subjectPvu IIen_US
dc.subjectLipoproteinen_US
dc.titleDNA polymorphism of Pvu II site in the lipoprotein lipase gene in patients with non-insulin dependent diabetes mellitusen_US
dc.typeArticleen_US
dspace.entity.typePublication

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