Salt inducible kinases as novel Notch interactors in the developing Drosophilaretina

dc.contributor.authorŞahin, H. Bahar
dc.contributor.authorSayın, Sercan
dc.contributor.authorHolder, Maxine
dc.contributor.authorBugra, Kuyaş
dc.contributor.authorÇelik, Arzu
dc.date.accessioned2020-07-14T12:43:44Z
dc.date.available2020-07-14T12:43:44Z
dc.date.issued2020
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Biyoinformatik ve Genetik Bölümüen_US
dc.description.abstractDevelopmental processes require strict regulation of proliferation, differentiation and patterning for the generation of final organ size. Aberrations in these fundamental events are critically important in tumorigenesis and cancer progression.Salt inducible kinases(Siks) are evolutionarily conserved genes involved in diverse biological processes, including salt sensing, metabolism, muscle, cartilage and bone formation, but their role in development remains largely unknown. Recent findings implicate Siks in mitotic control, and in both tumor suppression and progression. Using a tumor model in theDrosophilaeye, we show that perturbation of Sik function exacerbates tumor-like tissue overgrowth and metastasis. Furthermore, we show that bothDrosophila Sikgenes,Sik2andSik3, function in eye development processes. We propose that an important target of Siks may be the Notch signaling pathway, as we demonstrate genetic interaction between Siks and Notch pathway members. Finally, we investigate Sik expression in the developing retina and show that Sik2 is expressed in all photoreceptors, basal to cell junctions, while Sik3 appears to be expressed specifically in R3/R4 cells in the developing eye. Combined, our data suggest thatSikgenes are important for eye tissue specification and growth, and that their dysregulation may contribute to tumor formation.en_US
dc.description.sponsorshipEMBO installation granten_US
dc.description.sponsorshipBogazici Universityen_US
dc.description.sponsorshipTUBİTAKen_US
dc.identifier.citation3
dc.identifier.doi10.1371/journal.pone.0234744en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issn1932-6203
dc.identifier.issue6en_US
dc.identifier.pmid32542037en_US
dc.identifier.scopus2-s2.0-85090032482en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12469/3040
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0234744
dc.identifier.volume15en_US
dc.identifier.wosWOS:000542685100021en_US
dc.identifier.wosqualityQ2
dc.institutionauthorŞahin, H. Baharen_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.journalPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTranscription Factoren_US
dc.subjectAdherens Junctionsen_US
dc.subjectBinding Proteinen_US
dc.subjectGene-Expressionen_US
dc.subjectGlucose-Uptakeen_US
dc.subjectDrosophilaen_US
dc.subjectSIK2en_US
dc.subjectPolarityen_US
dc.subjectGrowthen_US
dc.subjectEyeen_US
dc.titleSalt inducible kinases as novel Notch interactors in the developing Drosophilaretinaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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