The protective effect of vitamin C vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injury

dc.contributor.authorKoyutürk, Meral
dc.contributor.authorBolkent, Şehnaz
dc.contributor.authorÖzdil, S
dc.contributor.authorArbak, Serap
dc.contributor.authorYanardağ, Refiye
dc.date.accessioned2019-06-27T08:00:54Z
dc.date.available2019-06-27T08:00:54Z
dc.date.issued2004
dc.description.abstractIn this study the effect of a combination of vitamin C vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced by oral administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C ( 250 mg/ kg) vitamin E ( 250 mg/kg) and selenium (0.5 mg/kg) for 3 days and absolute ethanol 1 hour after last antioxidant administration and were sacrificed 1 hour after absolute ethanol. Extreme degeneration in intestinal mucosa of rats given ethanol was observed morphologically. In addition an increase in neuronal nitric oxide synthase immunoreactive areas was observed in the rats of the group given ethanol. On the other hand a normal morphological appearance and a decrease in neuronal nitric oxide synthase immunoreactive areas were detected in the rats given ethanol + vitamin C + vitamin E + selenium. In the group to which ethanol was administered an increase in serum cholesterol and a decrease in serum albumin levels were determined. On the other hand in the group to which ethanol + vitamin C + vitamin E + selenium were administered serum cholesterol value decreased and the serum albumin level increased. As a result we can say that the combination of vitamin C vitamin E and selenium has a protective effect on ethanol-induced duodenal mucosal injury.en_US]
dc.identifier.citation17
dc.identifier.doi10.1191/0960327104ht468oaen_US
dc.identifier.endpage398
dc.identifier.issn0960-3271en_US
dc.identifier.issn0960-3271
dc.identifier.issue8
dc.identifier.pmid15346720en_US
dc.identifier.scopus2-s2.0-4444335965en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage391en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/152
dc.identifier.urihttps://doi.org/10.1191/0960327104ht468oa
dc.identifier.volume23en_US
dc.identifier.wosWOS:000223054200003en_US
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherArnold Hodder Headline Plc.en_US
dc.relation.journalHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDuodenal injuryen_US
dc.subjectEthanolen_US
dc.subjectNitric oxide synthaseen_US
dc.subjectSeleniumen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.titleThe protective effect of vitamin C vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injuryen_US
dc.typeArticleen_US
dspace.entity.typePublication

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