Synthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agents

dc.contributor.authorEşsiz, Şebnem
dc.contributor.authorÖzcan, Şeyda
dc.contributor.authorBalcıoğlu, Sevgi
dc.contributor.authorGencel, Melis
dc.contributor.authorNoma, Samir Abbas Ali
dc.contributor.authorEşsiz, Şebnem
dc.contributor.authorAteş, Burhan
dc.contributor.authorAlgül, Öztekin
dc.date.accessioned2020-10-07T11:30:20Zen_US
dc.date.available2020-10-07T11:30:20Zen_US
dc.date.issued2019en_US
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Biyoinformatik ve Genetik Bölümüen_US
dc.description.abstractIn this study, a series of B-ring fluoro substituted bis-chalcone derivatives were synthesized by Claisen-Schmidt condensation reactions and evaluated for their ability to inhibit xanthine oxidase (XO) and growth inhibitory activity against MCF-7 and Caco-2 human cancer cell lines, in vitro. According to the results obtained, the bis-chalcone with fluoro group at the 2 (4b) or 2,5-position (4g) of B-ring were found to be potent inhibitors of the enzyme with IC50 values in the low micromolar range. The effects of these compounds were about 7 fold higher than allopurinol. The binding modes of the bis-chalcone derivatives in the active site of xanthine oxidase were explained using molecular docking calculations. Also, compound 4g and 4h showed in vitro growth inhibitory activity against a panel of two human cancer cell lines 1.9 and 6.8 μM of IC50 values, respectively.en_US
dc.identifier.citation42
dc.identifier.doi10.1016/j.bioorg.2019.103149en_US
dc.identifier.issue10/01/19en_US
dc.identifier.pmid31382060en_US
dc.identifier.scopus2-s2.0-85071831143en_US
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12469/3470
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2019.103149
dc.identifier.volume91en_US
dc.identifier.wosWOS:000487812000046en_US
dc.identifier.wosqualityN/A
dc.institutionauthorGencel, Melisen_US
dc.institutionauthorEşsiz, Şebnemen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalBioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBis-chalconeen_US
dc.subjectClaisen-Schmidt condensationen_US
dc.subjectCytotoxicityen_US
dc.subjectInhibitionen_US
dc.subjectSynthesisen_US
dc.titleSynthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agentsen_US
dc.typeArticleen_US
dspace.entity.typePublication
relation.isAuthorOfPublicationa83da4e2-c934-413a-886f-2438d0a3fd58
relation.isAuthorOfPublication.latestForDiscoverya83da4e2-c934-413a-886f-2438d0a3fd58

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