Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials

dc.contributor.authorHanagasi, Hasmet A.
dc.contributor.authorGurvit, I. Hakan
dc.contributor.authorErmutlu, Numan
dc.contributor.authorKaptanoğlu, Gulustu
dc.contributor.authorKaramürsel, Sacit
dc.contributor.authorIdrisoğlu, Halil A.
dc.contributor.authorEmre, Murat
dc.contributor.authorDemiralp, Tamer
dc.date.accessioned2019-06-27T08:01:01Z
dc.date.available2019-06-27T08:01:01Z
dc.date.issued2002
dc.description.abstractThe presence of subclinical cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) is investigated using neuropsychological assessment and event-related potential recordings (ERP). An extensive battery of neuropsychological tests assessing the domains of attention memory language visuo-spatial and executive functions were administered to 20 non-demented patients with sporadic ALS and 13 age- and education-matched healthy control subjects. Mismatch negativity (MMN) P3b P3a (novelty P300) and contingent negative variation (CNV) were recorded. ALS patients were significantly impaired in tests of working memory sustained attention response inhibition naming verbal fluency and complex visuo-spatial processing. The memory impairment seemed to be secondary to deficits in forming learning strategies and retrieval. In ERP recordings P3a and P3b amplitudes of ALS patients were lower compared with the controls P3a latencies were significantly longer and mean CNV amplitudes were higher. These results indicate subclinical impairment of cognitive functions in patients with ALS. The pattern of cognitive impairment suggests the dysfunction of the frontal network. (C) 2002 Elsevier Science B.V. All rights reserved.en_US]
dc.identifier.citation105
dc.identifier.doi10.1016/S0926-6410(02)00110-6en_US
dc.identifier.endpage244
dc.identifier.issn0926-6410en_US
dc.identifier.issn0926-6410
dc.identifier.issue2
dc.identifier.pmid12067696en_US
dc.identifier.scopus2-s2.0-0036286044en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage234en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/211
dc.identifier.urihttps://doi.org/10.1016/S0926-6410(02)00110-6
dc.identifier.volume14en_US
dc.identifier.wosWOS:000178604900004en_US
dc.identifier.wosqualityN/A
dc.institutionauthorErmutlu, Numanen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.journalCognitive Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmyotrophic lateral sclerosisen_US
dc.subjectNeuropsychologyen_US
dc.subjectEvent-related potentialen_US
dc.subjectFrontal dysfunctionen_US
dc.titleCognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentialsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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