PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12469/4466

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Citation - WoS: 15
Citation - Scopus: 15
2d Materials (ws2, Mos2, Mose2) Enhanced Polyacrylamide Gels for Multifunctional Applications
(Mdpi, 2022) Uysal, Bengu Ozugur; Nayir, Seyma; Acba, Melike; Citir, Betul; Durmaz, Sumeyye; Kocoglu, Sevval; Yildiz, Ekrem
Multifunctional polymer composite gels have attracted attention because of their high thermal stability, conductivity, mechanical properties, and fast optical response. To enable the simultaneous incorporation of all these different functions into composite gels, the best doping material alternatives are two-dimensional (2D) materials, especially transition metal dichalcogenides (TMD), which have been used in so many applications recently, such as energy storage units, opto-electronic devices and catalysis. They have the capacity to regulate optical, electronic and mechanical properties of basic molecular hydrogels when incorporated into them. In this study, 2D materials (WS2, MoS2 and MoSe2)-doped polyacrylamide (PAAm) gels were prepared via the free radical crosslinking copolymerization technique at room temperature. The gelation process and amount of the gels were investigated depending on the optical properties and band gap energies. Band gap energies of composite gels containing different amounts of TMD were calculated and found to be in the range of 2.48-2.84 eV, which is the characteristic band gap energy range of promising semiconductors. Our results revealed that the microgel growth mechanism and gel point of PAAm composite incorporated with 2D materials can be significantly tailored by the amount of 2D materials. Furthermore, tunable band gap energies of these composite gels are crucial for many applications such as biosensors, cartilage repair, drug delivery, tissue regeneration, wound dressing. Therefore, our study will contribute to the understanding of the correlation between the optical and electronic properties of such composite gels and will help to increase the usage areas so as to obtain multifunctional composite gels.
Citation - WoS: 7
Citation - Scopus: 6
The acquisition and use of relative clauses in Turkish-learning children's conversational interactions: a cross-linguistic approach
(Cambridge University Press, 2019) Uzundağ, Berna A.; Küntay, Aylin C.
Using a cross-linguistic approach, we investigated Turkish-speaking children's acquisition and use of relative clauses (RCs) by examining longitudinal child-caregiver interactions and cross-sectional peer conversations. Longitudinal data were collected from 8 children between the ages of 8 and 36 months. Peer conversational corpus came from 78 children aged between 43 and 64 months. Children produced RCs later than in English (Diessel, 2004) and Mandarin (Chen & Shirai, 2015), and demonstrated increasing semantic and structural complexity with age. Despite the morphosyntactic difficulty of object RCs, and prior experimental findings showing a subject RC advantage, preschool-aged children produced object RCs, which were highly frequent in child-directed speech, as frequently as subject RCs. Object RCs in spontaneous speech were semantically less demanding (with pronominal subjects and inanimate head nouns) than the stimuli used in prior experiments. Results suggest that multiple factors such as input frequency and morphosyntactic and semantic difficulty affect the acquisition patterns.
The Acquisition and Use of Relative Clauses in Turkish-Learning Children's Conversational Interactions: a Cross-Linguistic Approach (vol 46, Pg 1142, 2019)
(Cambridge Univ Press, 2022) Uzundag, Berna A.; Kuntay, Aylin C.
[Abstract Not Available]
Citation - WoS: 1
Citation - Scopus: 1
Across Dimensions: Two- and Three-Dimensional Phase Transitions From the Iterative Renormalization-Group Theory of Chains
(2020) Keçoğlu, İbrahim; Berker, A. Nihat
Sharp two- and three-dimensional phase transitional magnetization curves are obtained by an iterative renormalization-group coupling of Ising chains, which are solved exactly. The chains by themselves do not have a phase transition or nonzero magnetization, but the method reflects crossover from temperaturelike to fieldlike renormalization-group flows as the mechanism for the higher-dimensional phase transitions. The magnetization of each chain acts, via the interaction constant, as a magnetic field on its neighboring chains, thus entering its renormalization-group calculation. The method is highly flexible for wide application.
Analogy Is Indispensable but Rule Is a Must: Insights From Turkish
(Cambridge Univ Press, 2022) Nakipoglu, Mine; Uzundag, Berna A.; Ketrez, F. Nihan
Inflectional morphology provides a unique platform for a discussion of whether morphological productivity is rule-based or analogy-based. The present study testing 140 children (range = 29 to 97 months; M(SD) = 64.1(18.8)) on an elicited production task investigated the acquisition of the irregular distribution in the Turkish aorist. Results suggested that to discover the allomorphs of the Turkish aorist, children initially carried out similarity comparisons between analogous exemplars, which helped them tap into phonological features to induce generalizations for regulars and irregulars. Thereafter to tackle the irregularity, children entertained competing hypotheses yielding overregularizations and irregularizations. While the trajectory of overregularizations implicated the gradual formulation of an abstraction based on type-frequency, irregularizations suggested both intrusion of analogous exemplars and children's attempts to default to an erroneous micro-generalization. Our findings supported a model of morphological learning that is driven by analogy at the outset and that invokes rule-induction in later stages.
Citation - WoS: 1
Citation - Scopus: 1
Assessing Protein-Ligand Binding Modes With Computational Tools: the Case of Pde4b
(Springer, 2017) Çifii, Gülşah; Aviyente, Viktorya; Akten, Ebru Demet; Monard, Gerald
In a first step in the discovery of novel potent inhibitor structures for the PDE4B family with limited side effects we present a protocol to rank newly designed molecules through the estimation of their IC values. Our protocol is based on reproducing the linear relationship between the logarithm of experimental IC values [(IC)] and their calculated binding free energies (). From 13 known PDE4B inhibitors we show here that (1) binding free energies obtained after a docking process by AutoDock are not accurate enough to reproduce this linear relationship
Citation - WoS: 5
Citation - Scopus: 5
Asymmetric Phase Diagrams, Algebraically Ordered Berezinskii-Kosterlitz Phase, and Peninsular Potts Flow Structure in Long-Range Spin Glasses
(Amer Physical Soc, 2022) Gurleyen, S. Efe; Berker, A. Nihat
The Ising spin-glass model on the three-dimensional (d = 3) hierarchical lattice with long-range ferromagnetic or spin-glass interactions is studied by the exact renormalization-group solution of the hierarchical lattice. The chaotic characteristics of the spin-glass phases are extracted in the form of our calculated, in this case continuously varying, Lyapunov exponents. Ferromagnetic long-range interactions break the usual symmetry of the spin-glass phase diagram. This phase-diagram symmetry breaking is dramatic, as it is underpinned by renormalization-group peninsular flows of the Potts multicritical type. A Berezinskii-Kosterlitz-Thouless (BKT) phase with algebraic order and a BKT-spin-glass phase transition with continuously varying critical exponents are seen. Similarly, for spin-glass long-range interactions, the Potts mechanism is also seen, by the mutual annihilation of stable and unstable fixed distributions causing the abrupt change of the phase diagram. On one side of this abrupt change, two distinct spin-glass phases, with finite (chaotic) and infinite (chaotic) coupling asymptotic behaviors are seen with a spin-glass to spin-glass phase transition.
Citation - WoS: 24
Citation - Scopus: 24
The Availability of Abortion at State Hospitals in Turkey: a National Study
(Elsevier, 2017) O'Neil, Mary Lou
Introduction: Abortion in Turkey has been legal since 1983 and remains so today. Despite this in 2012 the Prime Minister declared that in his opinion abortion was murder. Since then there has been growing evidence that abortion access particularly in state hospitals is being restricted although no new legislation has been offered. Objectives: The study aimed to determine the number of state hospitals in Turkey that provide abortions. Study design: The study employed a telephone survey in 2015-2016 where 431 state hospitals were contacted and asked a set of questions by a mystery patient. If possible information was obtained directly from the obstetrics/gynecology department. I removed specialist hospitals from the data set and the remaining data were analyzed for frequency and cross-tabulations were performed. Results: Only 7.8% of state hospitals provide abortion services without regard to reason which is provided for by the current law while 78% provide abortions when there is a medical necessity. Of the 58 teaching and research hospitals in Turkey 9 (15.5%) provide abortion care without restriction to reason 38 (65.5%) will do the procedure if there is a medical necessity and 11 (11.4%) of these hospitals refuse to provide abortion services under any circumstances. There are two regions encompassing 1.5 million women of childbearing age where no state hospital provides for abortion without restriction as to reason. Conclusion: The vast majority of state hospitals only provide abortions in the narrow context of a medical necessity and thus are not implementing the law to its full extent. It is clear that although no new legislation restricting abortion has been enacted state hospitals are reducing the provision of abortion services without restriction as to reason. Implications: This is the only nationwide study to focus on abortion provision at state hospitals. (C) 2017 Elsevier Inc. All rights reserved.
Citation - Scopus: 1
Background Tv and Infant-Family Interactions: Insights From Home Observations
(Wiley, 2024) Uzundag, Berna A.; Koskulu-Sancar, Suemeyye; Kuntay, Aylin C.
Background television has been found to negatively impact children's language development and self-regulatory skills, possibly due to decreased parent-child interactions. Most of the research on the relationship between background TV and caregiver-child interactions has been conducted in laboratory settings. In the current study, we conducted home observations and investigated whether infants engage in fewer interactions with family members in homes where background TV is more prevalent. We observed 32 infants at the ages of 8, 10, and 18 months in their home environments, coding for dyadic interactions (e.g., parent talking to and/or engaging with the child), triadic interactions (e.g., parent and infant play with a toy together), and infants' individual activities. Our findings revealed that background TV was negatively associated with the time infants spent in triadic interactions, positively associated with time spent engaging in individual activities, and not significantly related to the time spent in dyadic interactions. Apart from the relationship between background TV and individual activity time at 8 months, these associations remained significant even after accounting for families' socioeconomic status. These findings imply a correlation between background TV exposure and caregiver-infant-object interactions, warranting a longitudinal analysis with larger sample sizes.
Citation - WoS: 2
Citation - Scopus: 2
Behavioral but Not Psychological Control Predicts Self-Regulation, Adjustment Problems and Academic Self-Efficacy Among Early Adolescents
(Routledge Journals, Taylor & Francis Ltd, 2025) Harma, Mehmet; Aktas, Busra; Sumer, Nebi
Prior work has documented that parental psychological and behavioral control have varying impacts on self-regulation skills and social-academic outcomes in early adolescence, with effects differing across cultures. The present study explores the role of psychological and behavioral control in predicting adjustment difficulties and academic self-confidence through self-regulatory skills among early adolescents in Turkiye using data from mothers and their children (N = 295, Ngirls=145, Mage=12.14 years). The results yielded that parental behavioral control, but not psychological control, predicts self-regulation of adolescents, which, in turn, predicts adjustment and academic self-efficacy. Our results underscore the pivotal role of parental knowledge and monitoring, mainly through behavioral control strategies, in fostering psychological adjustment and academic self-efficacy in the Turkish cultural context. The discussion delves into the potential culture-specific effects of psychological control and the universal influence of behavioral control during early adolescence.
Better Reflective Functioning in Mothers Linked To Longer Joint Attention With Infants
(Elsevier Ltd, 2026) Koç, N.; Ünlü, H.; Uzundag, B.A.
Joint attention is a foundational precursor to later developmental outcomes such as vocabulary, intelligence, and theory of mind. Previous research has shown that maternal sensitivity, depressive symptoms, and parent-child attachment security are associated with attention-sharing behaviors between mothers and their infants. The present study examined the relationship between mothers’ reflective functioning (the ability to recognize and interpret one’s own and one’s child’s mental states, as well as the behaviors motivated by those mental states) and joint attention. Data were collected from 72 infants aged 10–16 months and their mothers. Results indicated that mothers who reported greater difficulty in understanding and distinguishing between their own and their child's mental states (i.e., higher prementalization) tended to engage in joint attention episodes that were shorter and more frequent, and they were also more likely to terminate these interactions. In contrast, mothers expressing greater interest and curiosity about their infants’ mental states spent longer periods in joint attention, initiated these episodes less often, and were less inclined to terminate them. Additionally, mothers who felt more certain about their infants’ mental states were less likely to end joint attention episodes. After controlling for infant age and socioeconomic status, higher levels of interest and certainty continued to predict lower maternal termination, while prementalization was still linked to a higher number of joint attention episodes. These findings suggest that mothers’ perceptions of their infants’ mental states shape how they engage in shared attention during everyday play interactions. © 2025 Elsevier Inc.
Citation - WoS: 12
Citation - Scopus: 12
Blind Dockings of Benzothiazoles To Multiple Receptor Conformations of Triosephosphate Isomerase From Trypanosoma Cruzi and Human
(Wiley-VCH Verlag GmbH, 2011) Kurkcuoglu, Zeynep; Ural, Gulgun; Akten, Ebru Demet; Doruker, Pemra
We aim to uncover the binding modes of benzothiazoles which have been reported as specific inhibitors of triosephosphate isomerase from the parasite Trypanosoma cruzi (TcTIM) by performing blind dockings on both TcTIM and human TIM (hTIM). Detailed analysis of binding sites and specific interactions are carried out based on ensemble dockings to multiple receptor conformers obtained from molecular dynamics simulations. In TcTIM dimer dockings the inhibitors preferentially bind to the tunnel-shaped cavity formed at the interface of the subunits whereas non-inhibitors mostly choose other sites. In contrast TcTIM monomer binding interface and hTIM dimer interface do not present a specific binding site for the inhibitors. These findings point to the importance of the tunnel and of the dimeric form for inhibition of TcTIM. Specific interactions of the inhibitors and their sulfonate-free derivatives with the receptor residues indicate the significance of sulfonate group for binding affinity and positioning on the TcTIM dimer interface. One of the inhibitors also binds to the active site which may explain its relatively higher inhibition effect on hTIM.
Citation - WoS: 7
Citation - Scopus: 6
Chemical and Biological Investigations of Allium Scorodoprasum L. Flower Extracts
(Mdpi, 2023) Dordevski, Nikoleta; Uba, Abdullahi Ibrahim; Zengin, Gokhan; Bozunovic, Jelena; Gasic, Uros; Ristanovic, Elizabeta; Ciric, Ana
This study was designed to investigate the impact of different extraction solvent systems on the chemical composition and biological activities of Allium scorodoprasum L. (Amaryllidaceae)-the medicinal plant that was traditionally used as a remedy in the medieval period in the Balkans. Targeted chemical analysis of nine different extracts was performed by UHPLC(-)HESI-QqQ-MS/MS. Antimicrobial and antibiofilm activities of the extracts were investigated on sixteen clinical isolates of bacteria, yeasts and dermatomycetes, all isolated from infected human skin and corneal formations. Cytotoxicity and wound-healing properties were tested on human immortalized keratinocytes (HaCaT cell line). Antioxidant activity was assessed by six different assays, while beneficial potential against certain neurodegenerative diseases and type 2 diabetes was determined in selected enzyme inhibition assays coupled with molecular modeling. The results showed that the obtained extracts were rich in phenolic compounds, especially flavonoid glycosides such as rutin and kaempferol 3-O-glucoside. All of the extracts showed antimicrobial, wound-healing, antioxidant and anti-enzymatic properties. This study is the first of its kind, linking the medieval medicinal use of wild-growing flowers of A. scorodoprasum with contemporary in vitro scientific approaches.
Citation - WoS: 3
Citation - Scopus: 5
Clinical Experience With Coronary Sinus Catheterization in Minimally Invasive Aortic Valve Surgery Under Transesophageal Echocardiography Guidance
(Kluwer Academic Publishers, 2002) Demirsoy, Ergun; Özbek, Uğur; Bayındır, Osman; Sönmez, Baris
We aimed to show conventional coronary sinus (CS) catheter could be used with transesophageal echocardiography (TEE) guidance through the limited surgical field in aortic valve surgery with 'J' sternotomy. This method was performed in 14 patients and completed successfully in 12. We believe that in minimally invasive aortic valve surgery the insertion of the conventional retrograde cardioplegia catheter to the CS with routine way may not be possible but application of TEE guidance is cost-effective and easily applicable method without significant complications.
Citation - WoS: 25
Citation - Scopus: 29
Collective Remembering and Future Forecasting During the Covid-19 Pandemic: How the Impact of Covid-19 Affected the Themes and Phenomenology of Global and National Memories Across 15 Countries
(Springer, 2023) Oner, Sezin; Watson, Lynn Ann; Adiguzel, Zeynep; Ergen, Irem; Bilgin, Ezgi; Curci, Antonietta; Cole, Scott
The COVID-19 pandemic created a unique set of circumstances in which to investigate collective memory and future simulations of events reported during the onset of a potentially historic event. Between early April and late June 2020, we asked over 4,000 individuals from 15 countries across four continents to report on remarkable (a) national and (b) global events that (i) had happened since the first cases of COVID-19 were reported, and (ii) they expected to happen in the future. Whereas themes of infections, lockdown, and politics dominated global and national past events in most countries, themes of economy, a second wave, and lockdown dominated future events. The themes and phenomenological characteristics of the events differed based on contextual group factors. First, across all conditions, the event themes differed to a small yet significant degree depending on the severity of the pandemic and stringency of governmental response at the national level. Second, participants reported national events as less negative and more vivid than global events, and group differences in emotional valence were largest for future events. This research demonstrates that even during the early stages of the pandemic, themes relating to its onset and course were shared across many countries, thus providing preliminary evidence for the emergence of collective memories of this event as it was occurring. Current findings provide a profile of past and future collective events from the early stages of the ongoing pandemic, and factors accounting for the consistencies and differences in event representations across 15 countries are discussed.
Citation - WoS: 72
Citation - Scopus: 75
Combined Radiofrequency Modified Maze and Mitral Valve Procedure Through a Port Access Approach: Early and Mid-Term Results
(Oxford University Press, 2003) Akpınar, Belhhan; Güden, Mustafa; Sağbaş, Ertan; Sanisoğlu, İlhan; Özbek, Uğur; Caynak, Barış; Bayındır, Osman
Objective: The aim of this study was to assess the feasibility and effectiveness of irrigated radiofrequency (RF) modified Maze procedure through a port access approach during mitral valve surgery and evaluate early and mid-term results. Material and method: During a 16 months time period 67 patients with chronic atrial fibrillation (AF) eligible for port access mitral valve surgery were randomly assigned to either Group A in which they underwent a combined procedure (N = 33) or Group B in which a valve procedure alone was performed (N = 34). Both groups were similar in terms of age sex valve pathology duration of AF left atrial diameter and left ventricle function (P > 0.05). Four had undergone previous operations. Results: Median follow-up was 10 months for both groups 95% CI (9.18-10.8). One patient in each group died early postoperatively (3 and 2.9%). Two patients required reoperation for bleeding one in each group (3 and 2.9%). There were two conversions to right thoracotomy. In Group A freedom from AF was 100% at the end of the operation (76% sinus 24% pacemaker) Six and twelve months freedom from AF was 87.2 and 93.6% respectively. In Group B freedom from AF at the end of operation was 41%. At the end of 6 and 12 months freedom from AF was 9.4% (P = 0.0001). One patient in Group A required a permanent pacemaker (3%). During follow-up one patient in Group A died of non-cardiac causes (3%). In Group B there were two late deaths: one cardiac (2.9%) and one neurologic (2.9%). There were no thromboembolic events detected in Group A during follow-up whereas two patients in Group B suffered this complication (6% P = 0.081). At 12 months functional capacity had improved for patients in both groups (P < 0.0001). Conclusion: The combination of mitral valve surgery and irrigated RF Maze procedure was safe and efficient through a port access approach. There were no procedure related complications like esophageal or coronary artery injury. Early and mid-term results were favourable with 93.6% of patients free of AF at 1 year in comparison to the 9.4% of the control group. The data is not sufficient to reach any conclusions in terms of thromboembolic rates despite favourable results for the RF Maze group. Nevertheless in terms of feasibilty sinus rhythm restoration and overall outcome early results are encouraging and we advocate the use of the combined procedure through a port access approach. (C) 2003 Elsevier Science B.V. All rights reserved.
Citation - WoS: 9
Citation - Scopus: 9
Complete Density Calculations of Q-State Potts and Clock Models: Reentrance of Interface Densities Under Symmetry Breaking
(Amer Physical Soc, 2020) Artun, E. Can; Berker, A. Nihat
All local bond-state densities are calculated for q-state Potts and clock models in three spatial dimensions, d = 3. The calculations are done by an exact renormalization group on a hierarchical lattice, including the density recursion relations, and simultaneously are the Migdal-Kadanoff approximation for the cubic lattice. Reentrant behavior is found in the interface densities under symmetry breaking, in the sense that upon lowering the temperature, the value of the density first increases and then decreases to its zero value at zero temperature. For this behavior, a physical mechanism is proposed. A contrast between the phase transition of the two models is found and explained by alignment and entropy, as the number of states q goes to infinity. For the clock models, the renormalization-group flows of up to 20 energies are used.
Citation - WoS: 2
Citation - Scopus: 3
Composite Hydrogel of Polyacrylamide/Starch as a Novel Amoxicillin Delivery System
(Mdpi, 2024) Poyraz, Yagmur; Baltaci, Nisa; Hassan, Gana; Alayoubi, Oubadah; Uysal, Bengu Ozugur; Pekcan, Onder
This study investigates the development and characterization of a novel composite hydrogel composed of polyacrylamide (PAAm), starch, and gelatin for use as an amoxicillin delivery system. The optical properties, swelling behavior, and drug release profile of the composite hydrogel's were studied to evaluate its efficacy and potential applications. UV-visible spectroscopy was employed to determine the optical properties, revealing significant transparency in the visible range, which is essential for biomedical applications. The incorporation of starch and gelatin into the polyacrylamide matrix significantly enhanced the hydrogel's swelling capacity and biocompatibility. Studies on drug delivery demonstrated a sustained release profile of amoxicillin in simulated gastrointestinal fluids, which is essential for maintaining therapeutic levels for a prolonged amount of time. The results indicate that the composite hydrogel of PAAm/starch/gelatin has good swelling behavior, appealing optical characteristics, and a promising controlled drug release mechanism. These results point to this hydrogel's considerable potential as a drug delivery method, providing a viable path toward enhancing the medicinal effectiveness of amoxicillin and maybe other medications.
Citation - WoS: 1
Citation - Scopus: 1
Covid-19 Modeling Based on Real Geographic and Population Data
(Tubitak Scientific & Technological Research Council Turkey, 2023) Baysazan, Emir; Berker, A. Nihat; Mandal, Hasan; Kaygusuz, Hakan
Background/aim: Intercity travel is one of the most important parameters for combating a pandemic. The ongoing COVID-19 pandemic has resulted in different computational studies involving intercity connections. In this study, the effects of intercity connections during an epidemic such as COVID-19 are evaluated using a new network model. Materials and methods: This model considers the actual geographic neighborhood and population density data. This new model is applied to actual Turkish data by means of provincial connections and populations. A Monte Carlo algorithm with a hybrid lattice model is applied to a lattice with 8802 data points. Results: Around Monte Carlo step 70, the number of active cases in Turkiye reaches up to 8.0% of the total population, which is followed by a second wave at around Monte Carlo step 100. The number of active cases vanishes around Monte Carlo step 160. Starting with Istanbul, the epidemic quickly expands between steps 60 and 100. Simulation results fit the actual mortality data in Turkiye. Conclusion: This model is quantitatively very efficient in modeling real-world COVID-19 epidemic data based on populations and geographical intercity connections, by means of estimating the number of deaths, disease spread, and epidemic termination.
Citation - WoS: 15
Citation - Scopus: 17
Crystallographic Structure Versus Homology Model: a Case Study of Molecular Dynamics Simulation of Human and Zebrafish Histone Deacetylase 10
(Taylor & Francis, 2020) Uba, Abdullahi İbrahim; Yelekçi, Kemal
Histone deacetylase (HDAC) 10 has been implicated in the pathology of various cancers and neurodegenerative disorders, making the discovery of novel inhibitors of the isoform an important endeavor. However, the unavailability of crystallographic structure of human HDAC10 (hHDAC10) hinders structure-based drug design effort. Previously, we reported the homology modeled structure of human HDAC10 built using the crystallographic structure of Danio rerio (zebrafish) HDAC10 (zHDAC10) (Protein Data Bank (PDB) ID; 5TD7, released on 24 May 2017) as a template. Here, in continuation with our study, both hHDAC10 and zHDAC10, and their respective complexes with trichostatin A (TSA), quisinostat, and the native ligand (in 5TD7), 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol (PDB ID; FKS) were submitted to 100 ns-long unrestrained molecular dynamics (MD) simulations. Comparative analyses of the MD trajectories revealed that zHDAC10 and its complexes displayed higher stability than hHDAC10 and its corresponding complexes over time. Nonetheless, docking of active and inactive set molecules revealed that more reliable conformations of hHDAC10 could be obtained at an extended time period. This study may shed more light on the reliability of hHDAC10 modeled structure for use in selective inhibitor design.Communicated by Ramaswamy H. Sarma.

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