Effects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats
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Date
2005
Authors
Koyutürk, Meral
Tunali, Sevim
Bolkent, Şehnaz
Yanardağ, Refiye
Journal Title
Journal ISSN
Volume Title
Publisher
Humana Press Inc.
Abstract
The aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. Degenerative changes were observed in diabetic animals by light and transmission electron microscopes. Although there were individual differences in diabetic animals to which vanadium was given some reduction of degenerative changes were detected. After 60 d of treatment serum aspartate and alanine transaminase alkaline phosphatase blood glucose levels liver lipid peroxidation and nonenzymatic glycosylation significantly increased but liver glutathione levels significantly decreased in the diabetic group. On the other hand treatment with vanadyl sulfate reversed these effects. As a result it might be concluded that vanadyl sulfate has a protective effect on damage of liver of streptozotocin-induced diabetic rats.
Description
Keywords
Streptozotocin, Liver tissue, Vanadyl sulfate, Light microscopy, Electron microscopy, Biochemistry
Turkish CoHE Thesis Center URL
Citation
41
WoS Q
N/A
Scopus Q
N/A
Source
Volume
104
Issue
3
Start Page
233
End Page
247