Effects of Vanadyl Sulfate on Liver of Streptozotocin-Induced Diabetic Rats

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dc.contributor.authorKoyutürk, Meral
dc.contributor.authorTunali, Sevim
dc.contributor.authorBolkent, Şehnaz
dc.contributor.authorYanardağ, Refiye
dc.date.accessioned2019-06-27T08:00:52Z
dc.date.available2019-06-27T08:00:52Z
dc.date.issued2005
dc.description.abstractThe aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. Degenerative changes were observed in diabetic animals by light and transmission electron microscopes. Although there were individual differences in diabetic animals to which vanadium was given some reduction of degenerative changes were detected. After 60 d of treatment serum aspartate and alanine transaminase alkaline phosphatase blood glucose levels liver lipid peroxidation and nonenzymatic glycosylation significantly increased but liver glutathione levels significantly decreased in the diabetic group. On the other hand treatment with vanadyl sulfate reversed these effects. As a result it might be concluded that vanadyl sulfate has a protective effect on damage of liver of streptozotocin-induced diabetic rats.en_US]
dc.identifier.citation41
dc.identifier.doi10.1385/BTER:104:3:233en_US
dc.identifier.endpage247
dc.identifier.issn0163-4984en_US
dc.identifier.issn0163-4984
dc.identifier.issue3
dc.identifier.pmid15930593en_US
dc.identifier.scopus2-s2.0-20444468073en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/129
dc.identifier.urihttps://doi.org/10.1385/BTER:104:3:233
dc.identifier.volume104en_US
dc.identifier.wosWOS:000230354900005en_US
dc.language.isoenen_US
dc.publisherHumana Press Inc.en_US
dc.relation.journalBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStreptozotocinen_US
dc.subjectLiver tissueen_US
dc.subjectVanadyl sulfateen_US
dc.subjectLight microscopyen_US
dc.subjectElectron microscopyen_US
dc.subjectBiochemistryen_US
dc.titleEffects of Vanadyl Sulfate on Liver of Streptozotocin-Induced Diabetic Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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